P-Chlorophenol (cas 106-48-9) Molecular Structure

CAS No. 106-48-9 (P-Chlorophenol )

Molecular Formula: C6H5ClOMolecular Weight: 128.56

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References of P-Chlorophenol cas 106-48-9

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TCLo inhalation 10gm/m3/8H (10000mg/m3) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: IRRITABILITY
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
mammal (species unspecified) LD50 oral 500mg/kg (500mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified) LD50 skin 1gm/kg (1000mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mouse LCLo inhalation 3200mg/m3/2H (3200mg/m3) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 9, 1992.
mouse LD50 intraperitoneal 332mg/kg (332mg/kg) ? Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975.
mouse LD50 oral 367mg/kg (367mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: COMA
Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. Vol. 25, Pg. 339, 1985.
mouse LD50 unreported 605mg/kg (605mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.
rat LC50 inhalation 11mg/m3 (11mg/m3) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
rat LD50 intraperitoneal 281mg/kg (281mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958.
rat LD50 oral 670mg/kg (670mg/kg) ? Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.
rat LD50 skin 1500mg/kg (1500mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
rat LD50 subcutaneous 1030mg/kg (1030mg/kg) ? Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.
rat LD50 unreported 625mg/kg (625mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.

Safety

Poison by inhalation and intraperitoneal routes. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe skin and eye irritant. Human systemic effects by inhalation: excitement, irritability. Mutation data reported. Combustible when exposed to heat or flame. To fight fire, use water, spray, mist, fog, foam, dry chemical. When heated to decomposition it emits toxic fumes of Cl?.
Hazard Codes:?HarmfulXn,DangerousN
Risk Statements: 20/21/22-51/53-50?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R50:Very toxic to aquatic organisms.
Safety Statements: 28-61-28A-24/25-60?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S24/25:Avoid contact with skin and eyes.?
S60:This material and its container must be disposed of as hazardous waste.
RIDADR: UN 2020 6.1/PG 3
WGK Germany: 2
RTECS: SK2800000
HazardClass: 6.1
PackingGroup of 4-Chlorophenol (CAS NO.106-48-9): III