Tamsulosin hydrochloride (cas 106463-17-6) Molecular Structure

CAS No. 106463-17-6 (Tamsulosin hydrochloride )

Molecular Formula: C20H29ClN2O5SMolecular Weight: 444.97

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References of Tamsulosin hydrochloride cas 106463-17-6

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5085, 1990.
mouse LD50 intravenous 98mg/kg (98mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
mouse LD50 oral 1023mg/kg (1023mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
mouse LD50 subcutaneous 254mg/kg (254mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 2169, 1993.
rat LD50 intravenous 70mg/kg (70mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
rat LD50 oral 650mg/kg (650mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.
rat LD50 subcutaneous 347mg/kg (347mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5071, 1990.

Safety

A poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx, SOx, HCl, and Cl?.