2-Propylvaleric acid sodium salt (cas 1069-66-5) Molecular Structure

CAS No. 1069-66-5 (2-Propylvaleric acid sodium salt )

Molecular Formula: C8H15NaO2Molecular Weight: 166.19

Related Products Information

Page:1/16 < >
Contact Supplier
  • Sodium valproate

    Updatetime:Feb 14 2018

    FOB Price:1 USD/Kilogram Purity:95%, 99% Min. Order:1/Kilogram Supply Ability:50 Year/Metric Ton

    DetailDesc:Name: 2-Propylvaleric acid sodium salt Synonyms: sodium 2-propylpentanoate; sodium valproate; Valproate Sodium CAS Registry number: 1069-66-5 EINECS:213-961-8 Molecular Formula: C8H15NaO2 Boiling Point: 220°C at 760 mmHg Flash Point: STABILITY Water:soluble Appearance: white p...

    Tel:86-571-88938639
    Address:9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road
    Hangzhou Dayangchem Co., Ltd.

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier MSNMSN SkypeSkype

  • Top Quality 99% Sodium 2-propylpentanoate CAS number: 1069-66-5

    Updatetime:Feb 11 2018

    FOB Price:1 USD/Gram Purity:99% Min. Order:10/Gram Supply Ability:5 Month/Metric Ton

    DetailDesc: English name: Sodium 2-propylpentanoate English Synonyms: 2-propyl-pentanoicacisodiumsalt; 2-propylvalericacidsodiumsalt; 2-propyl-valericacisodiumsalt; dipropylacetatesodium; eurekene; kw6066n; labazene; orfiril CAS number: 1069-66-5 Molecular formula: C8H15NaO2 Molecular weigh...

    Tel:86-1732-7098554
    Address:shuanglong road,jiangning, nanjing,jiangsu
    Nanjing Bangnuo Biotechnology Co., Ltd

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Sodium 2-propylpentanoateCAS NO.: 1069-66-5

    Updatetime:Feb 09 2018

    FOB Price:1000 USD/Kilogram Purity:99% Min. Order:1/Kilogram Supply Ability:10 Day/Metric Ton

    DetailDesc: CAS: 1069-66-5 Precise quality: 166.09700 Molecular formula: C8H15NaO2 logP: 0.95270 Molecular weight: 166.19300 PSA: 40.13000 Enquiries to check the supplier immediately Using WeChat scan, pay attention to the encyclopedia The basic information Chinese name: valproate Chinese a...

    Tel:86-153-73023168
    Address:NO.18TH VANKE NORTH STREET,CHENGHUA DISTRICT, CHENGDU CITY , SICHUAN PROVINCE
    chengdu yancey import& export trade co.,ltd

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Trading Company

    Contact Supplier SkypeSkype

  • CAS 1069-66-5 2-Propylvaleric acid sodium salt

    Updatetime:Feb 07 2018

    FOB Price:1 USD/Kilogram Purity:99%min Min. Order:1/Kilogram Supply Ability:1000 Month/Kilogram

    DetailDesc:Name: 2-Propylvaleric acid sodium salt Synonyms: sodium 2-propylpentanoate; sodium valproate; Valproate Sodium CAS Registry number: 1069-66-5 EINECS:213-961-8 Molecular Formula: C8H15NaO2 Boiling Point: 220°C at 760 mmHg Flash Point: STABILITY Water:soluble Appearance: white p...

    Tel:86-188-74586545
    Address:East and West Lake District, Wuhan, China
    Hubei XinRunde Chemical Co., Ltd

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Sodium 2-propylpentanoate

    Updatetime:Aug 04 2017

    Min. Order:

    DetailDesc:Sodium 2-propylpentanoate

    Tel:86-311-66600578
    Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.
    AOPHARM

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier MSNMSN SkypeSkype

  • Pentanoic acid,2-propyl-, sodium salt (1:1)

    Updatetime:Jul 18 2017

    FOB Price:100 USD/Kilogram Purity:99% Min. Order:1/Kilogram Supply Ability:100 Month/Kilogram

    DetailDesc:APIs Pharmaceutical Adjuvant Biochemicals & Biotech products

    Tel:86-571-85829152
    Address:Room 606, Fuyi Center, #298 Quanfuqiao Road, Jiang
    Jinlan Pharm-Drugs Technology Co., Limited

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Pentanoic acid, 2-propyl-, sodium salt (1:1)

    Updatetime:Feb 17 2016

    DetailDesc:Hangzhou J&H Chemical Co., Ltd is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals, pharmaceuticals, and specialities.

    Tel:86-571-87396430
    Address:No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China
    Hangzhou J&H Chemical Co., Ltd

    Diamond member Diamond member Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier

  • CAS No. 1069-66-5 (2-Propylvaleric acid sodium salt )

    Updatetime:Oct 05 2017

    FOB Price:99 USD/Kilogram Purity:98% 99% Min. Order:1/Kilogram Supply Ability:10000 Month/Kilogram

    DetailDesc: Identification of 1069-66-5 Name: 2-Propylvaleric acid sodium salt (Related Reference) EINECS: 213-961-8 Molecular Formula: C8H15NaO2 CAS Registry Number: 1069-66-5 Synonyms: sodium 2-propylpentanoate; sodium valproate; Valproate Sodium InChI: InChI=1/C8H16O2.Na/c1-3-5-7(6-4-2)8...

    Tel:86-17083-639935
    Address:Huaian East Road Yuhua District Shijiazhuang Hebe
    Shulin Li

    Diamond member Diamond member

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Sodium 2-propylpentanoate

    Updatetime:Jun 28 2017

    FOB Price:1 USD/Gram Purity:98% Min. Order:1/Gram Supply Ability:100 Month/Kilogram

    DetailDesc:We could receive custom synthesis according to your requirements from lab scale to commercial scale

    Tel:86-21-60542966
    Address:Lane 299 Bisheng Rd,Pudong District
    Hui Chem Company Limited

    Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Sodium Valproate 1069-66-5

    Updatetime:Sep 29 2016

    FOB Price:1 USD/Kilogram Purity:99 Min. Order:1/Kilogram Supply Ability:1000 Month/Kilogram

    DetailDesc: Sodium Valproate Aliase: Sodium 2-Propylpentanoate CAS No.: 1069-66-5 MF: C8H15NaO2 MM: 166.19 EC No.: 213-961-8 MP: 300ºC Appearance: white powder InChI: 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 Sodium Valproate is clinically use for simple o...

    Tel:86-27-59261290
    Address:daijiashan 45,jiangan economic departmen zone,wuhan,hubei,China
    Wuhan Dahua Weiye Pharmaceutical Co.,Ltd

    Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier

  • Pentanoic acid,2-propyl-, sodium salt (1:1)

    Updatetime:Jul 28 2016

    Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

    DetailDesc:Pentanoicacid, 2-propyl-, sodium salt (9CI);Valeric acid, 2-propyl-, sodium salt(7CI,8CI);Acediprol;Convulex;Depacon;Depakene;Depakene R;Depakene syrup8;Depakin;Depakine chronosphere;Dipropylacetate sodium;Epilim;KW 6066N;Micropakine LP;Orfiril;Selenica R;Sodium 2-propylpentanoat...

    Tel:0086-531-58773055
    Address:No.59 Gongye South RD
    Jinan Haohua Industry Co., Ltd.

    Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Valproate semisodium

    Updatetime:Jul 12 2016

    FOB Price:10 USD/Kilogram Purity:99% Min. Order:10/Gram Supply Ability:20 Month/Metric Ton

    DetailDesc:1.Full experience of large numbers containers loading in Chinese sea port. 2.Fast shipment by reputed shipping line. 3.Packing with pallet as buyer's special request. 4.Best service after shipment with e mail. 5.Cargoes together with container sales seervice available. 6.Full exp...

    Tel:86-27-59009407
    Address:20#Xudong Street,Wuhan China
    Wuhan Senwayer Century chemical Co.,Ltd

    Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier SkypeSkype

  • Sodium Valproate(2-Propylvaleric acid sodium salt)

    Updatetime:Jun 24 2014

    DetailDesc:Sodium Valproate(2-Propylvaleric acid sodium salt)

    Tel:86-21-61900721
    Address:Room 3-201, No.787, Kangqiao Road, Pudong New District, Shanghai, China
    run-biotech Co., Ltd.

    Audited Supplier

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier

  • Active Pharmaceutical Ingredients

    Updatetime:Jan 30 2018

    Tel:0086-021-31608287
    Address:Rm506, No.80,Yichuan Rd.,Putuo District, Shanghai 200065,

    Introduction:TocopharmCo.LimitedisanindustryleaderinthefieldofActivePharmaceuticalIngredients(API),pharmaceuticalintermediatesandresearchchemicals.Wespecializeinresearch,productionandtradingofthesechemicals.Wearealsoabletoprovidecustomsynthesistoourcustomers.TocopharmoperateslaboratoriesandfactoriesinmainlandChina.Ourproductsaremadetothestrictestqualitycontrolstandardsandmeetallgovernmentregulations.AtTocophar...

    Tocopharm Co., Ltd.

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier MSNMSN

  • Sodium valproate

    Updatetime:Oct 31 2017

    Purity:99% Min. Order:1/Kilogram Supply Ability:2000 

    DetailDesc: Product name: Sodium valproate Synonyms: Sodium 2-propylpentanoate ;2-propyl-pentanoicacisodiumsalt;2-propylvalericacidsodiumsalt;2-propyl-valericacisodiumsalt;dipropylacetatesodium;eurekene;kw6066n; labazene;orfiril CAS No.: 1069-66-5 Molecular formula: C8H15NaO2 Molecular weig...

    Tel:86-531-68659623
    Address:Industrial North Road, Licheng District, Jinan City, Shandong
    Jinan Huicheng Pharm Tech Co., Ltd

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier

  • Sodium Valproate

    Updatetime:Sep 18 2017

    DetailDesc: EC NO:213-961-8 INCHI:InChI=1/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 MF:C 8 H 15 NaO 2 MW:166.19 Synonyms: sodium 2-propylpentanoate;sodium valproate;Valproate Sodium;

    Tel:+971-7-2461461
    Address:RAK Air port road,RAK
  • Sodium valproate

    Updatetime:Sep 04 2017

    FOB Price:50 USD/Kilogram Purity:99% Min. Order:25/Kilogram Supply Ability:2000 Month/Kilogram

    DetailDesc: Product name: Sodium valproate Synonyms: Sodium 2-propylpentanoate ;2-propyl-pentanoicacisodiumsalt;2-propylvalericacidsodiumsalt;2-propyl-valericacisodiumsalt;dipropylacetatesodium;eurekene;kw6066n;labazene;orfiril CAS No.: 1069-66-5 Molecular formula: C8H15NaO2 Molecular weigh...

    Tel:86-530-5408166
    Address:Heze High-tech Develpment Zone(The Great Wall West Road and Lanzhou Road intersection), 27400, Heze City, Shandong Province
    Shandong Green Bio-Pharmaceutical Co., Ltd.

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier MSNMSN SkypeSkype

  • Sodium Valproate

    Updatetime:Jan 05 2017

    Purity:Purity:≥99% on the anhydrous basis;

    DetailDesc: Name: Sodium Valproate CAS NO: 1069-66-5 M.F.: C 8 H 15 NaO 2 M.W: 166.20 Appearance: white crystalline powder or pellet, mildly astringent flavor, strong hygroscopicity ; Very freely soluble in water, freely soluble in methanol and ethanol, practically insoluble in acetone; Loss on drying: 3% PH: 7.5~9 Related impurities: The peak area ...

    Tel:86-731-88280158
    Address:Bio-Pharmaceutical Industrial Park,Liuyang Hunan,China
    Hunan Dinuo Pharmaceutical Co.,Ltd.

    Country/Region:China

    Business Type: Manufacturer

    Contact Supplier

  • Sodium 2-propylpentanoate

    Updatetime:Dec 28 2016

    Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

    DetailDesc:Sodium 2-propylpentanoate(CAS#1069-66-5)is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field etc.

    Tel:86-21-50677091
    Address:Room 302, Building 7, No.1000, Jinhai Road, Shanghai, 201206, China
    Shanghai Meicheng Chemical Co., Ltd.

    Country/Region:China

    Business Type: Distributor/Wholesaler

    Contact Supplier

  • 2-Propylvaleric acid sodium salt

    Updatetime:Mar 29 2016

    FOB Price:Inquiry USD/Gram Purity:97% Min. Order:1/Gram Supply Ability:100 Day/Gram

    DetailDesc:Name:2-Propylvaleric acid sodium salt CAS NO:1069-66-5 Molecular Formula:C8H15NaO2 Molecular Weight:166.19 Melting Point:50℃Stability:Stable. Combustible. Incompatible with strong oxidizing agents, ammonia.

    Tel:1-631-5046093
    Address:45-16 Ramsey Road, Shirley, NY 11967, USA
    Boc Sciences

    Country/Region:United States

    Business Type: Manufacturer

    Contact Supplier

<Pre12345..16Next > Go to page

References of 2-Propylvaleric acid sodium salt cas 1069-66-5

} Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YV7876000
CHEMICAL NAME :
Valeric acid, 2-propyl-, sodium salt
CAS REGISTRY NUMBER :
1069-66-5
LAST UPDATED :
199801
DATA ITEMS CITED :
66
MOLECULAR FORMULA :
C8-H15-O2.Na
MOLECULAR WEIGHT :
166.22
WISWESSER LINE NOTATION :
OVY3&Y1&1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
214 mg/kg/30D-I
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
250 mg/kg/10D-I
TOXIC EFFECTS :
Gastrointestinal - changes in structure or function of endocrine pancreas Blood - hemorrhage
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - coma Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - muscle weakness
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
1820 mg/kg/12W-I
TOXIC EFFECTS :
Behavioral - sleep Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - dehydration
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - muscle contraction or spasticity Liver - liver function tests impaired
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
970 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1029 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
509 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
977 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
832 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1420 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
565 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1468 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
824 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1740 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
72800 mg/kg/1Y-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Vascular - structural changes in vessels
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
109 gm/kg/13W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in other cell count (unspecified) Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
97200 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25280 mg/kg/21D-C
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
9500 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle weakness Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
58500 mg/kg/90D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle weakness Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1620 mg/kg
SEX/DURATION :
female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2700 mg/kg
SEX/DURATION :
female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2700 mg/kg
SEX/DURATION :
female 1-39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2800 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1500 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5904 mg/kg
SEX/DURATION :
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5904 mg/kg
SEX/DURATION :
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1950 mg/kg
SEX/DURATION :
female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1350 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
750 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3360 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1400 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
201 mg/kg
SEX/DURATION :
female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
600 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
464 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
340 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
400 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
90 mg/kg
SEX/DURATION :
female 3 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3600 mg/kg
SEX/DURATION :
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
450 mg/kg
SEX/DURATION :
female 7-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
300 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
600 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
490 mg/kg
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
464 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 21-31 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 22-31 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3 gm/kg
SEX/DURATION :
female 21-50 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 21-50 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2600 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4095 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5200 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4550 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 243,63,1990 *** REVIEWS *** TOXICOLOGY REVIEW DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 13,81,1977 TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,58,1979