Baclofen (cas 1134-47-0) Molecular Structure

CAS No. 1134-47-0 (Baclofen )

Molecular Formula: C10H12ClNO2Molecular Weight: 213.66

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    DetailDesc: English name: Baclofen CAS: 1134-47-0 Molecular Formula: C10H12ClNO2 Molecular weight: 213.66100

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References of Baclofen cas 1134-47-0

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 571ug/kg (0.571mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Annals of Pharmacotherpy. Vol. 27, Pg. 883, 1993.
man TDLo oral 4286ug/kg (4.286mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 4, Pg. 552, 1986.
man TDLo oral 14mg/kg (14mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 59, 1983.
man TDLo oral 3429mg/kg (3429mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 291, 1994.
man TDLo unreported 857ug/kg/2D-I (0.857mg/kg) BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Italian Journal of Neurological Sciences. Vol. 12, Pg. 323, 1991.
mouse LD50 intravenous 31mg/kg (31mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2069, 1979.
mouse LD50 oral 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 576, 1982.
mouse LD50 subcutaneous 103mg/kg (103mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
rat LD50 intravenous 78mg/kg (78mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
rat LD50 oral 145mg/kg (145mg/kg)   Drugs in Japan Vol. 6, Pg. 576, 1982.
rat LD50 subcutaneous 115mg/kg (115mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
women TDLo oral 8mg/kg (8mg/kg) CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Postgraduate Medical Journal. Vol. 57, Pg. 580, 1981.
women TDLo oral 9mg/kg (9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Postgraduate Medical Journal. Vol. 56, Pg. 865, 1980.
women TDLo oral 18mg/kg (18mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Toxicology, Clinical Toxicology. Vol. 22, Pg. 11, 1984.
women TDLo parenteral 25ug/kg/2D-I (0.025mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: COMA
International Journal of Clinical Pharmacology, Therapy and Toxicology. Vol. 29, Pg. 274, 1991.

Safety

Poison by ingestion, subcutaneous and intravenous routes. Human systemic effects by ingestion: blood pressure lowering, coma, muscle weakness, pulse rate decrease, respiratory depression. When heated to decomposition it emits toxic fumes of Cl and NOx. A muscle relaxant.
Safety Information of Baclofen (CAS NO.1134-47-0)
Hazard Codes:  T,Xn
Risk Statements: 61-25-36/37/38-42/43-20/21/22 
R61:May cause harm to the unborn child. 
R25 :Toxic if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R42/43:May cause sensitization by inhalation and skin contact. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 53-22-36/37/39-45-52-26 
S53:Avoid exposure - obtain special instructions before use. 
S22:Do not breathe dust. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S52:Not recommended for interior use on large surface areas. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MW5084200
HazardClass: 6.1(b)
PackingGroup: III