Quinine (cas 130-95-0) Molecular Structure

CAS No. 130-95-0 (Quinine )

Molecular Formula: C20H24N2O2Molecular Weight: 324.42

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    DetailDesc: Quinine CAS No.: 130-95-0 Name: Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)- Superlist Name: Quinine Formula: C20H24N2O2 Synonyms: Quinine(8CI);(-)-Quinine;(8S,9R)-Quinine;(R)-(-)-Quinine;6'-Methoxycinchonidine;Chinine;NSC 192949;(8α,9R)-6'-methoxycinchonan-9-ol;(3α,8α,9R)-6'-methoxycinchonan-9-ol;(R)-(6-Methoxy-4-chinolinyl)[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2] Molecular Weight:...

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References of Quinine cas 130-95-0

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 100mg/kg (100mg/kg)   Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
cat LDLo subcutaneous 100mg/kg (100mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
dog LDLo subcutaneous 180mg/kg (180mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
frog LDLo intramuscular 400mg/kg (400mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
frog LDLo oral 1500mg/kg (1500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
frog LDLo subcutaneous 200mg/kg (200mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
guinea pig LD50 oral 1800mg/kg (1800mg/kg)   Schweizerische Medizinische Wochenschrift. Vol. 84, Pg. 351, 1954.
man LDLo unreported 294mg/kg (294mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intraperitoneal 115mg/kg (115mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1760, 1985.
mouse LD50 intravenous 68mg/kg (68mg/kg)   Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse LDLo subcutaneous 200mg/kg (200mg/kg) CARDIAC: OTHER CHANGES

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA

BLOOD: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
pigeon LDLo intramuscular 500mg/kg (500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
rabbit LDLo intravenous 70mg/kg (70mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
rabbit LDLo oral 500mg/kg (500mg/kg)   Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
rabbit LDLo subcutaneous 231mg/kg (231mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1320, 1935.
rat LD intraperitoneal > 100mg/kg (100mg/kg)   Cancer Research. Vol. 52, Pg. 2797, 1992.
rat LDLo oral 800mg/kg (800mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 100, Pg. 408, 1950.
rat LDLo subcutaneous 200mg/kg (200mg/kg) CARDIAC: OTHER CHANGES

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA

BLOOD: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 205, Pg. 129, 1948.
women TDLo oral 74mg/kg (74mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR

GASTROINTESTINAL: NAUSEA OR VOMITING
American Journal of Ophthalmology. Vol. 90, Pg. 403, 1980.

Safety

Human poison by unspecified route. Experimental poison by subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Moderately toxic experimentally by ingestion. An experimental teratogen. Human systemic effects by ingestion: visual field changes, tinnitus, and nausea or vomiting. Human teratogenic effects by ingestion: developmental abnormalities of the central nervous system, body wall, and musculoskeletal, cardiovascular, and hepatobiliary systems. Experimental reproductive effects. Mutation data reported. Can cause temporary loss of vision. Quinine dermatitis is an occupational hazard to barbers particularly, and generally to people who work with quinine tonics, medicaments, or cosmetics. An irritant to mucous membranes. Combustible when exposed to heat or flame. Decomposes on exposure to light. When heated to decomposition it emits toxic fumes of NOx. Used to treat malaria.
Hazard Codes: HarmfulXn,IrritantXi
Risk Statements: 36/37/38-42/43-22-20/22-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin. 
R42/43:May cause sensitization by inhalation and skin contact. 
R22:Harmful if swallowed. 
R20/22:Harmful by inhalation and if swallowed. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-26-36/37-45-37/39-36-7 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S37/39:Wear suitable gloves and eye/face protection. 
S36:Wear suitable protective clothing. 
S7:Keep container tightly closed.
WGK Germany: 3
RTECS of Quinine (CAS NO.130-95-0): VA6020000