Urea,N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso- (cas 13909-09-6) Molecular Structure

CAS No. 13909-09-6 (Urea,N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso- )

Molecular Formula: C10H18ClN3O2Molecular Weight: 247.72

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  • Semustine

    Updatetime:Feb 24 2018

    FOB Price:2 USD/Kilogram Purity:95%, 99% Min. Order:1/Kilogram Supply Ability:10 Year/Metric Ton

    DetailDesc:Name: Urea,N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso- Synonyms: Urea,1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso- (8CI);ICIG 1110;Me-CCNU;Methyllomustine;Methyl-CCNU;N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea;N'-(4-Methylcyclohexyl)-N-(2-chloroethyl)...

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    DetailDesc:Urea,1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso- (8CI);1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea;1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosurea;1-(2-Chloroethyl)-3-(4-methylcyclohexyl)nitrosourea; ICIG 1110; Me-CCNU; Methyllomustine; Methyl-CCNU;N-(2-C...

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References of Urea,N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso- cas 13909-09-6

} Toxicity

1.    

skn-rbt 5 mg/24H rns

    TXCYAC    Toxicology. 14 (1979),117.
2.    

mmo-sat 100 nmol/plate

    JJIND8    JNCI, Journal of the National Cancer Institute. 65 (1980),149.
3.    

mma-sat 100 nmol/plate

    JJIND8    JNCI, Journal of the National Cancer Institute. 65 (1980),149.
4.    

dnd-esc 50 µmol/L

    MUREAV    Mutation Research. 89 (1981),95.
5.    

dni-mus:oth 10 µmol/L

    CNREA8    Cancer Research. 43 (1983),5837.
6.    

orl-hmn TDLo:22 mg/kg/60W-C:CAR

    NEJMAG    New England Journal of Medicine. 309 (1983),1079.
7.    

ipr-rat TDLo:30 mg/kg/7W-I:CAR

    CANCAR    Cancer. 40 (Suppl 4)(1977),1935.
8.    

orl-hmn TDLo:90 mg/kg:BLD,GIT

    CCYPBY    Cancer Chemotherapy Reports, Part 3. 4 (1973),257.
9.    

orl-hmn TDLo:6 mg/kg:GIT,BLD

    CTRRDO    Cancer Treatment Reports. 60 (1976),709.
10.    

orl-chd LDLo:5550 mg/kg/30W-I

    NEJMAG    New England Journal of Medicine. 300 (1979),1200.
11.    

orl-chd TDLo:37,950&

Safety

Confirmed human carcinogen producing leukemia. Experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, intravenous, and possibly other routes. Mutation data reported. Human systemic effects by ingestion: nausea or vomiting, damage to kidney tubules and glomeruli, and hematuria (blood in the urine). When heated to decomposition it emits very toxic fumes of Cl and NOx. See also N-NITROSO COMPOUNDS.Safety information of Semustine (CAS NO.13909-09-6):
Hazard Codes  ToxicT
Risk Statements 
45 May cause cancer
46 May cause heritable genetic damage
23/24/25 Toxic by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements 
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR  3249
WGK Germany  3
RTECS  YS5000000
HazardClass  6.1(a)
PackingGroup  II