Ftorafur (cas 17902-23-7) Molecular Structure

CAS No. 17902-23-7 (Ftorafur )

Molecular Formula: C8H9FN2O3Molecular Weight: 200.167063

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  • Ftorafur

    Updatetime:Oct 24 2017

    FOB Price:1 USD/Kilogram Purity:95%, 99% Min. Order:1/Kilogram Supply Ability:20 Year/Metric Ton

    DetailDesc:Name: Ftorafur Synonyms: 5-Fluoro-1-(tetrahydro-2-furyl)uracil; 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil; Tegafur; 5-fluoro-1-(tetrahydrofuran-2-yl)uracil; 1-Naphthol-3,8-Disulfonic Acid; Epsilone Acid; 5-fluoro-1-oxolan-2-yl-pyrimidine-2,4-dione CAS Registry number: 17902-23-7 E...

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    Updatetime:Oct 24 2017

    Purity:97%

    DetailDesc:organic latermediates

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  • Tegafur

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    DetailDesc: Tegafur CAS:17902-23-7

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  • Ftorafur white powder

    Updatetime:Oct 20 2017

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    DetailDesc: Name: Poly(oxy-1,2-ethanediyl),a-isotridecyl-w-hydroxy- Synonyms: ArlyponIT 10; Arlypon IT 10/80; Arlypon IT 16; Arlypon IT 8; Berol 048; Dehscoxid 732;Ethox 2400; Ethox TDA 9; Ethoxylated isotridecanol; Ethoxylated isotridecylalcohol; Eusapon S; Exxal F 5716; Genapol V 4739; Ge...

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    Updatetime:Sep 20 2017

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    Updatetime:Sep 06 2017

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    Updatetime:Aug 04 2017

    Purity:99%

    DetailDesc:White Crystalline Powder

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    Updatetime:Jul 18 2017

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    Updatetime:Jun 14 2017

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    DetailDesc: Jinan Jianfeng Chemical Co.Ltd is a leading research-driven family-managed pharmaceutical company. In the principle of “ Quality Oriented ” , Jianfeng passed the certification of ISO9001:2008 Quality Management System. The products meet USP, EP, JP and CP standards a...

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  • Tegafur 17902-23-7

    Updatetime:Feb 04 2017

    FOB Price:100 USD/Gram Purity:99% Supply Ability:mass stock 

    DetailDesc: Tegafur Basic information Product Name: Tegafur Synonyms: TEGAFUR;1-(tetrahydrofuran-2-yl)-5-fluoro-uraci;1-(tetrahydrofuran-2-yl)-5-fluorouracil;3h)-pyrimidinedione,5-fluoro-1-(tetrahydro-2-furanyl)-4(1h;5-fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione;5-fluoro-1-(tetrahyd...

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    DetailDesc: Product Name: Tegafur Synonyms: TEGAFUR;1-(tetrahydrofuran-2-yl)-5-fluoro-uraci;1-(tetrahydrofuran-2-yl)-5-fluorouracil;3h)-pyrimidinedione,5-fluoro-1-(tetrahydro-2-furanyl)-4(1h;5-fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione;5-fluoro-1-(tetrahydro-2-furyl)-uraci;5-fluoro...

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  • Tegafur

    Updatetime:Sep 22 2016

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    Introduction:FoundedbyagroupofveteransfromtheUSbiopharmaceuticalindustryin2010,P&TisnowaleadingShanghai-basedCROcompanyprovidingdrugdiscoveryanddevelopmentservicesworldwide.Withourtechnicalexpertiseandexcellentresearchfacilities,weofferbroadandintegratedchemicalsynthesis(customsynthesis,librarydesignandsynthesis),medicinalchemistry(hitgeneration,leadoptimization,andpreclinicaldevelopment),biological(earlyh...

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  • Antimetabolite antitumor drugs CAS : 17902-23-7 Tegafur / eric15719

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    DetailDesc: Product Details: Contacting Information: Contacting Person : Eric Adam Skype : eric15719 E-mail : eric(at)chembj(dot)com Product Name: Tegafur Synonyms: TEGAFUR;1-(tetrahydrofuran-2-yl)-5-fluoro-uraci;1-(tetrahydrofuran-2-yl)-5-fluorouracil;3h)-pyrimidinedione,5-fluoro-1-(tetrah...

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  • 5-Fluoro-1-(tetrahydro-2-furyl)uracil

    Updatetime:Jul 28 2016

    Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

    DetailDesc:1-(2-Tetrahydrofuryl)-5-fluorouracil ; 1-(Tetrahydro-2-furanyl)-5-fluoro-2,4-pyrimidinedione;1-(Tetrahydrofuran-2-yl)-5-fluorouracil;2,4(1H,3H)Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-;5-24-06-00285 (Beilstein Handbook Reference);5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-py...

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    Updatetime:Jul 12 2016

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  • Tegafur

    Updatetime:May 13 2016

    Purity:98.00% Min. Order:1/Gram

    DetailDesc:【Appearance】 White Crystalline Powder【Density】 1.45 g/cm3【Melting Point】 168-171℃【Boiling Point】 oCat760mmHg【Refractive Index】 1.557【Flash Point】 oC【Water】 Soluble in hot water【Solubilities】 Soluble in hot water【Stability】 Stable under normal temperatures and pressures.【Storage temp】 2-8°C

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    Updatetime:Nov 20 2015

    FOB Price:1 USD/Kilogram Purity:98% Min. Order:1/Kilogram Supply Ability:1 Year/Kilogram

    DetailDesc: Suzhou Yacoo Chemical Reagent Corporation was founded in 2003. It is a high-tech enterprise which specializing in biomedicine, electrochemical materials, import and export business, electronic mall, Up to now,It has 10 years history on chemical sales, R & D and production o...

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  • Ftorafur

    Updatetime:Nov 02 2015

    DetailDesc:Name: Ftorafur Synonyms: 5-Fluoro-1-(tetrahydro-2-furyl)uracil; 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil; Tegafur; 5-fluoro-1-(tetrahydrofuran-2-yl)uracil; 1-Naphthol-3,8-Disulfonic Acid; Epsilone Acid; 5-fluoro-1-oxolan-2-yl-pyrimidine-2,4-dione CAS Registry number: 17902-23-7 EINECS:241-846-2 Molecular Formula: C8H9FN2O3 Boiling Point: oCat760mmHg Flash Point: oC Density: 1.45 g/cm 3 Water:Sol...

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  • Ftorafur

    Updatetime:May 09 2017

    FOB Price:100 RMB/Kilogram Purity:≥98 Min. Order:1/Kilogram Supply Ability:100000 Month/Kilogram

    DetailDesc: Tegafur 17902-23-7 White crystal powder Oteracil potassium 2207-75-2 Gimeracil 103766-25-2 pemetrexed disodium 150399-23-8 Enterprise standards zoledronic acid 118072-93-8 C5H10N2P2.H2O Enterprise standards Potassium Hexachloroplatinate 16921-30-5 K2PtCl6 Enterprise standards Po...

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  • Tegafur;5-Fluoro-1-(tetrahydro-2-furyl)uracil; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione

    Updatetime:Aug 02 2016

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References of Ftorafur cas 17902-23-7

} Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YR0450000
CHEMICAL NAME :
Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-
CAS REGISTRY NUMBER :
17902-23-7
BEILSTEIN REFERENCE NO. :
0525766
LAST UPDATED :
199706
DATA ITEMS CITED :
43
MOLECULAR FORMULA :
C8-H9-F-N2-O3
MOLECULAR WEIGHT :
200.19
WISWESSER LINE NOTATION :
T6NVMVJ EF A- BT5OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
197 mg/kg/23D-I
TOXIC EFFECTS :
Brain and Coverings - encephalitis Behavioral - muscle contraction or spasticity Behavioral - antipsychotic
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
640 mg/kg/8D
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Vascular - BP lowering not characterized in autonomic section Gastrointestinal - nausea or vomiting
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
930 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - ulceration or bleeding from stomach Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
685 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
775 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
493 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
34 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Vascular - other changes Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
36 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
44 mg/kg
TOXIC EFFECTS :
Vascular - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17640 mg/kg/12W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14040 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
700 mg/kg/40W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg/5W-I
TOXIC EFFECTS :
Blood - normocytic anemia Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20160 mg/kg/24W-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
880 mg/kg/80D-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1170 mg/kg/9D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1365 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1820 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
350 mg/kg/5W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
11046 mg/kg/4.7Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
810 mg/kg
SEX/DURATION :
female 17-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
550 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
420 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
630 mg/kg
SEX/DURATION :
female 7-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
210 mg/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
630 mg/kg
SEX/DURATION :
female 6-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
DOSE/DURATION :
100 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,241,1981