CAS No. 21679-14-1 (9H-Purin-6-amine,9-b-D-arabinofuranosyl-2-fluoro- )
Molecular Formula: C10H12FN5O4Molecular Formula: 285.23
Identification of 21679-14-1
- Name:
- 9H-Purin-6-amine,9-b-D-arabinofuranosyl-2-fluoro- (Related Reference)
- EINECS:
- 244-525-5
- Molecular Formula:
- C10H12FN5O4
- CAS Registry Number:
- 21679-14-1
- Synonyms:
- Adenine,9-b-D-arabinofuranosyl-2-fluoro- (8CI);2-Fluoro Ara-A;2-Fluoro-9-b-D-arabinofuranosyladenine;2-Fluoroadenine arabinoside;9-b-D-Arabinofuranosyl-2-fluoroadenine;9-b-D-Arabinosyl-2-fluoroadenine;F-ara-A;NSC 118218;NSC 118218H;Fludarabine Base;
- InChI:
- InChI=1/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
- Molecular Structure:
- This structure is also available as a 2d Mol file
Chemical Properties
- Appearance:
- white solid
- Molecular Weight:
- 285.23
- Density:
- 2.17g/cm3
- Boiling Point:
- 747.3°Cat760mmHg
- Melting Point:
- 265-268°C
- Flash Point:
- 405.8°C
- Storage Temperature:
- 2-8°C
- Refractive index:
- 1.876
- Solubility:
- Very soluble
- Biological Activity:
- Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .
- Usage:
Used as an antineoplastic
Safety Data of 21679-14-1
- Risk Codes:
- R23/24/25;R36/37/38;R39
- Safety Statements:
- S26;S36/37;S45
- MSDS infomation:
- 9H-Purin-6-amine,9-b-D-arabinofuranosyl-2-fluoro- (21679-14-1).msds
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