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Bupropion hydrochloride (cas 31677-93-7) Molecular Structure

Bupropion hydrochloride(CAS No. 31677-93-7)

  • Molecular Formula: C13H18ClNO.HCl
  • Molecular Weight:

Identification of 31677-93-7

  • Name:Bupropion hydrochloride
  • EINECS:250-759-9
  • Molecular Formula:C13H18ClNO.HCl
  • CAS Registry Number:31677-93-7
  • Synonyms: 1-Propanone,1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-, hydrochloride (9CI);Amfebutamone hydrochloride;1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride;2-tert-Butylamino-1-(3-chlorophenyl)-propan-1-one hydrochloride;
  • Molecular Structure:Bupropion hydrochloride C13H18ClNO.HCl (cas 31677-93-7) Molecular Structure

Chemical Properties

  • Water solubility:Soluble
  • Boiling Point:371.4 °C at 760 mmHg
  • Melting Point:233-234℃
  • Flash Point:178.4 °C
  • Solubility:Soluble
  • Biological Activity:Non-selective inhibitor of dopamine and noradrenalin transporters (K i values are 1.4, 2.8 and 45 μ M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo .
  • Appearance:white crystalline powder
  • Usage:

    A selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation

Preparation Products
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ChinaDiamond member Hangzhou Dayangchem Co., Ltd.
Bupropion hydrochloride
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ChinaDiamond member Zouping Mingxing Chemical Co.,Ltd.
Purity:99 , Bupropion hydrochloride CAS Number :31677 -93-7 Packaging Specifications : No Specification Chinese Synonyms : 2 - tert-butyl- amino-3 '- chloropropiophenone hydrochloride ; bupropion hydrochloride ; bupropion hydrochlo..
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ChinaDiamond member Hubei Nosk Chemical Co.,Ltd
Molecular Formula: C 26 H 30 ClN 3 O 6 Molecular Weight: 516.04 InChI: InChI=1/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(1
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ChinaDiamond member Shanghai P&T Fine Chemical Co., Ltd.
Founded by a group of veterans from the US biopharmaceutical industry in 2010, P&T is now a leading Shanghai-based CRO company providing drug discovery and development services worldwide. With our technical expertise and..
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Address: Lane No.36, Zhongke road 2195, Zhangjiang high-tech park, Pudong new area Shanghai, China China
ChinaSilver member Nanjing Chemlin Chemical Co., Ltd.
Purity:usp 32 , Bupropion hydrochloride
Tel: 86-25-83697070
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Address: Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China China
China ZHENGZHOU SIGMA CHEMICAL COP., LTD
Purity:99% , Name: Bupropion hydrochoride CAS No.:31677-93-7 Molecular formula:C13H18ClNO·HCL Molecular Weight:276.2 Specification Property: white crystal Melting Point:233-234℃ Assay:99% Package:5kg/drum Usage:antidepressiv..
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China HangZhou Peak Chemical Co.,Ltd
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China Wuxi Hexia Chemical Company
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China Ningbo Jiasi Chemical Co.,Ltd.
Bupropion Hydrochloride
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China Wujiang Yingchuang Chemical Co., Ltd.
Profile: Wujiang Yingchuang Chemical Co., Ltd. specializes in the development and production of new drugs and pharmaceutical intermediates. Our products include benzene, pyridine, pyrimidine, quinoline, indole, pyrazine,..
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India CLEARSYNTH LABS (P) LTD
5-Hydroxy Bupropion D6
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China Microchem
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China Wis-Zone Trading Co., Ltd.
Wis-Zone Trading Co., Ltd. dedicates in ex-import of pharmaceutical intermediates, APIs, CD-R dyes and DVD-R dyes, special chemicals and chiral chemicals. It has good cooperation with many companies in pharmaceutical and..
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China Sanmen Eastsky Pharmaceutical Co.,Ltd
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Address: Room8402,Saigete Garden,Dahutang Development Zone, Sanmen City,Zhejiang,China China
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References of Bupropion hydrochloride

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 329mg/kg (329mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE

CARDIAC: OTHER CHANGES		 Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 321, 1997.
man TDLo oral 2143ug/kg/2D- (2.143mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: MUSCLE WEAKNESS

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Annals of Pharmacotherpy. Vol. 33, Pg. 931, 1999.
man TDLo oral 64mg/kg (64mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999.
mouse LD50 intraperitoneal 230mg/kg (230mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ANALGESIA		 Journal of Pharmacy and Pharmacology. Vol. 29, Pg. 767, 1977.
mouse LD50 oral 544mg/kg (544mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA		 Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 1, 1981.
rat LD50 intraperitoneal 210mg/kg (210mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Journal of Pharmacy and Pharmacology. Vol. 29, Pg. 767, 1977.
rat LD50 oral 482mg/kg (482mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 1, 1981.
women TDLo oral 2mg/kg (2mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: FOOD INTAKE (ANIMAL)		 American Journal of Psychiatry. Vol. 142, Pg. 1459, 1985.
women TDLo oral 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Clinical Psychiatry. Vol. 54, Pg. 162, 1993.
women TDLo oral 90mg/kg (90mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999.
women TDLo oral 180mg/kg (180mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 634, 1999.
women TDLo oral 180mg/kg (180mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 American Journal of Emergency Medicine. Vol. 12, Pg. 183, 1994.

Safety

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx and Cl?.
Hazard Codes:?IrritantXi,Xn
Risk Statements: 22?
R22:Harmful if swallowed.
Safety Statements: 36?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: UG8858000

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