D-Streptamine,O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl-(1?4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3) (cas 3810-74-0) Molecular Structure

CAS No. 3810-74-0 (D-Streptamine,O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl-(1?4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3) )

Molecular Formula: C42H84N14O36S3Molecular Formula: 1457.38

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References of D-Streptamine,O-2-deoxy-2-(methylamino)-a-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-formyl-a-L-lyxofuranosyl-(1?4)-N1,N3-bis(aminoiminomethyl)-, sulfate (2:3)

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 oral 400mg/kg (400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 14, Pg. 510, 1969.
infant TDLo intraperitoneal 170mg/kg (170mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Medical Journal. Vol. 1, Pg. 557, 1961.
mouse LD50 intravenous 90200ug/kg (90.2mg/kg) ? Antibiotiki. Vol. 18, Pg. 444, 1973.
mouse LD50 oral 430mg/kg (430mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
mouse LD50 subcutaneous 403mg/kg (403mg/kg) ? Antibiotics Annual. Vol. 4, Pg. 574, 1956/1957.
rat LD50 oral 430mg/kg (430mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.
rat LD50 subcutaneous 600mg/kg (600mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 597, 1962.

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Safety

Moderately toxic by ingestion and subcutaneous routes. Human teratogenic effects by intramuscular route: developmental abnormalities of the eye and ear. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also STREPTOMYCIN and SULFATES.