CAS No. 443-48-1 (Metronidazole )
Molecular Formula: C6H9N3O3Molecular Formula: 171.15
Identification of 443-48-1
- Name:
- Metronidazole (Related Reference)
- EINECS:
- 207-136-1
- Molecular Formula:
- C6H9N3O3
- CAS Registry Number:
- 443-48-1
- Synonyms:
- Bexon;Vagilen;1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;Meronidal;Trikojol;Novonidazol;RP 8823;Eumin;Metronidazole (JP14/USP);Bayer 5360;Trichopol;Trichex;Sanatrichom;Nalox;Trikamon;1-Hydroxyethyl-2-methyl-5-nitroimidazole;Metric 21;Monasin;Giatricol;Orvagil;MTZ;Metronidazol;NIDA;Trichazol;Flagyl;Deflamon;Entizol;2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole;1-(.beta.-Hydroxyethyl)-2-methyl-5-nitroimidazole;Trikozol;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-(.beta.-Ethylol)-2-methyl-5-nitro-3-azapyrrole;Klion;Arilin;Clont;Trimeks;Danizol;Efloran;Methronidazole;Trivazol;Acromona;1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole;Flagesol;Tricocet;Monagyl;Vertisal;Prestwick_334;Klont;Flegyl;Tricowas B;Trichomonacid pharmachim;Trichopal;Trichocide;Flagemona;Trichomol;Metronidaz;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1-(β-Ethylol)-2-methyl-5-nitro-3-azapyrrole;1-(β-Hydroxyethyl)-2-methyl-5-nitroimidazole;NSC-50364;1-(β-Oxyethyl)-2-methyl-5-nitroimidaz-ole;2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol;
- InChI:
- InChI=1/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
- Molecular Structure:
- This structure is also available as a 2d Mol file
Chemical Properties
- Appearance:
- white to slightly yellow crystalline powder
- Molecular Weight:
- 171.15
- Density:
- 1.45 g/cm3
- Boiling Point:
- 405.4 °C at 760 mmHg
- Melting Point:
- 159-163℃
- Flash Point:
- 199 °C
- Storage Temperature:
- 2-8°C
- Refractive index:
- 1.612
- Solubility:
- <0.1 g/100 mL at 20 °C in water
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- Usage:
Microbiocide.
Safety Data of 443-48-1
- Risk Codes:
- R40
- Safety Statements:
- S36/37;S45
- MSDS infomation:
- Metronidazole (443-48-1).msds
- Let supplier Know exactly what you’re looking for,Post Buying Request
- Dissatisfied what you’re looking for?Send your question(s)here
References of Metronidazole
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 39600mg/kg/4W (39600mg/kg) | PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE BEHAVIORAL: HEADACHE |
International Journal of Clinical Pharmacology Research. Vol. 19, Pg. 83, 1999. |
| man | TDLo | oral | 3570ug/kg/D (3.57mg/kg) | LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: OTHER CHANGES |
JAMA, Journal of the American Medical Association. Vol. 193, Pg. 1128, 1965. |
| man | TDLo | oral | 1030mg/kg/8W (1030mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH |
British Medical Journal. Vol. 2, Pg. 610, 1977. |
| mouse | LD50 | intraperitoneal | 870mg/kg (870mg/kg) | ? | Polish Journal of Pharmacology and Pharmacy. Vol. 42, Pg. 471, 1990. |
| mouse | LD50 | oral | 3800mg/kg (3800mg/kg) | ? | Journal of Medicinal Chemistry. Vol. 20, Pg. 1522, 1977. |
| mouse | LD50 | subcutaneous | 3640mg/kg (3640mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
| rat | LD50 | oral | 3gm/kg (3000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974. |
| women | TDLo | intravenous | 100mg/kg/5D-I (100mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: IRRITABILITY BEHAVIORAL: TOXIC PSYCHOSIS |
American Journal of Psychiatry. Vol. 154, Pg. 1169, 1997. |
| women | TDLo | oral | 12mg/kg (12mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR |
British Medical Journal. Vol. 292, Pg. 174, 1986. |
| women | TDLo | oral | 40mg/kg (40mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Southern Medical Journal. Vol. 78, Pg. 627, 1985. |
Hazard Codes? of Metronidazole (CAS NO.443-48-1):?
Xn
T
Risk Statements: 40-46-45
R40: Limited evidence of a carcinogenic effect.?
R45: May cause cancer.?
R46: May cause heritable genetic damage.
Safety Statements: 36/37-45-53
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: NI5600000
F: 8
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: paresthesia, nerve or sheath structural changes, eye changes, tremors, fever, jaundice and other liver changes, hearing-acuity changes, somnolence, and ataxia. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
msn
skype