Metronidazole (cas 443-48-1) Molecular Structure

CAS No. 443-48-1 (Metronidazole )

Molecular Formula: C6H9N3O3Molecular Formula: 171.15

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    DetailDesc:Name:Metronidazole CAS NO:443-48-1 Molecular Formula:C6H9N3O3 Molecular Weight:171.15 Melting Point:188℃ Stability:Stable. Combustible. Incompatible with strong oxidizing agents, ammonia.

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References of Metronidazole cas 443-48-1

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 39600mg/kg/4W (39600mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE

BEHAVIORAL: HEADACHE
International Journal of Clinical Pharmacology Research. Vol. 19, Pg. 83, 1999.
man TDLo oral 3570ug/kg/D (3.57mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

LIVER: OTHER CHANGES
JAMA, Journal of the American Medical Association. Vol. 193, Pg. 1128, 1965.
man TDLo oral 1030mg/kg/8W (1030mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH
British Medical Journal. Vol. 2, Pg. 610, 1977.
mouse LD50 intraperitoneal 870mg/kg (870mg/kg) Polish Journal of Pharmacology and Pharmacy. Vol. 42, Pg. 471, 1990.
mouse LD50 oral 3800mg/kg (3800mg/kg) ? Journal of Medicinal Chemistry. Vol. 20, Pg. 1522, 1977.
mouse LD50 subcutaneous 3640mg/kg (3640mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
rat LD50 oral 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
women TDLo intravenous 100mg/kg/5D-I (100mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: IRRITABILITY

BEHAVIORAL: TOXIC PSYCHOSIS
American Journal of Psychiatry. Vol. 154, Pg. 1169, 1997.
women TDLo oral 12mg/kg (12mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: TREMOR
British Medical Journal. Vol. 292, Pg. 174, 1986.
women TDLo oral 40mg/kg (40mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Southern Medical Journal. Vol. 78, Pg. 627, 1985.

Safety

Hazard Codes of Metronidazole (CAS NO.443-48-1):HarmfulXnToxicT
Risk Statements: 40-46-45
R40: Limited evidence of a carcinogenic effect.
R45: May cause cancer.
R46: May cause heritable genetic damage.
Safety Statements: 36/37-45-53
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: NI5600000
F: 8
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: paresthesia, nerve or sheath structural changes, eye changes, tremors, fever, jaundice and other liver changes, hearing-acuity changes, somnolence, and ataxia. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.