CAS No. 50-23-7 (Hydrocortisone )
Molecular Formula: C21H30O5Molecular Formula: 362.46
Identification of 50-23-7
- Name:
- Hydrocortisone (Related Reference)
- EINECS:
- 200-020-1
- Molecular Formula:
- C21H30O5
- CAS Registry Number:
- 50-23-7
- Synonyms:
- Cortisol(8CI);11b,17,21-Trihydroxypregn-4-ene-3,20-dione;11b,17,21-Trihydroxyprogesterone;11b,17a,21-Trihydroxypregn-4-ene-3,20-dione;11b-Hydroxycortisone;17-Hydroxycorticosterone;4-Pregnene-11b,17a,21-triol-3,20-dione;Acticort;Aeroseb HC;Ala-Cort;Anflam;Anti-inflammatory hormone;CaldeCort Spray;Cetacort;Cobadex;Cortanal;Cortef;Corticreme;Cortiment;Cortispray;Cortril;Dermocortal;Dihydrocostisone;Domolene-HC;DuoCort;Efcorbin;Eldecort;Esiderm H;Evacort;
- InChI:
- InChI=1/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
- Molecular Structure:
- This structure is also available as a 2d Mol file
Chemical Properties
- Appearance:
- crystalline white powder
- Molecular Weight:
- 362.46
- Density:
- 1.28g/cm3
- Boiling Point:
- 566.4 °C at 760 mmHg
- Melting Point:
- 213-220℃
- Flash Point:
- 310.4 °C
- Alpha:
- 166 o (C=1, C2H5OH 25 oC)
- Refractive index:
- 1.594
- Solubility:
- H2O: 100 mg/mL
Safety Data of 50-23-7
- Risk Codes:
- R62;R63
- Safety Statements:
- S36/37;S45
- MSDS infomation:
- Hydrocortisone (50-23-7).msds
MSDS Documents
- 1.Sigma-Aldrich www.sigmaaldrich.com:
- 2.Science Lab www.sciencelab.com/xMSDS-Hydrocortisone-9924292:
- 3.Bausch Lomb www.bausch.com/en_US/msds/pharma_mz/065-01.pdf:
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References of Hydrocortisone
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 400mg/kg/10D- (400mg/kg) | BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | Psychopharmacology Vol. 145, Pg. 260, 1999. |
| mouse | LD50 | subcutaneous | > 500mg/kg (500mg/kg) | ? | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(3), Pg. 26, 1990. |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | ? | Japanese Journal of Pharmacology. Vol. 21, Pg. 377, 1971. |
| rat | LD50 | subcutaneous | 449mg/kg (449mg/kg) | ? | Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. |
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Hazard Codes: Xn
WGK Germany: 3
Risk Statements: 63-62-40?
R62: Risk of impaired fertility.?
R63: Possible risk of harm to the unborn child.?
R40: Limited evidence of a carcinogenic effect.
Safety Statements of Hydrocortisone (CAS NO.50-23-7): 36/37-45-36-22?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36: Wear suitable protective clothing.?
S22: Do not breathe dust.
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