4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine (cas 50-33-9) Molecular Structure

CAS No. 50-33-9 (4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine )

Molecular Formula: C19H20N2O2Molecular Weight: 308.38

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References of 4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine cas 50-33-9

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 100mg/kg (100mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
dog LD50 intravenous 121mg/kg (121mg/kg) BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog LD50 oral 332mg/kg (332mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980.
guinea pig LD50 oral 250mg/kg (250mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1207, 1969.
hamster LD50 oral 1260mg/kg (1260mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
mammal (species unspecified) LD50 intraperitoneal 300mg/kg (300mg/kg) BEHAVIORAL: ANALGESIA European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 21, Pg. 277, 1986.
mammal (species unspecified) LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: ANALGESIA European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 21, Pg. 277, 1986.
man TDLo oral 17500ug/kg/3W (17.5mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Annals of Internal Medicine. Vol. 41, Pg. 1075, 1954.
man TDLo oral 2426mg/kg/24H (2426mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Annals of Emergency Medicine. Vol. 20, Pg. 204, 1991.
man TDLo unreported 200mg/kg/5W-I (200mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: HEMATURIA
British Medical Journal. Vol. 282, Pg. 950, 1981.
mouse LD50 intramuscular 430mg/kg (430mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 97, 1977.
mouse LD50 intraperitoneal 128mg/kg (128mg/kg) ? Pharmaceutical Chemistry Journal Vol. 19, Pg. 33, 1985.
mouse LD50 intravenous 90mg/kg (90mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
mouse LD50 oral 238mg/kg (238mg/kg) ? Pharmacological Research Communications. Vol. 18, Pg. 241, 1986.
mouse LD50 subcutaneous 230mg/kg (230mg/kg) ? Journal of Pharmacy and Pharmacology. Vol. 7, Pg. 1022, 1955.
mouse LD50 unreported 128mg/kg (128mg/kg) ? Farmatsevtichnii Zhurnal Vol. (5), Pg. 26, 1983.
rabbit LD50 intravenous 146mg/kg (146mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 129, 1960.
rabbit LD50 oral 781mg/kg (781mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980.
rat LD50 intramuscular 220mg/kg (220mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 665, 1960.
rat LD50 intraperitoneal 142mg/kg (142mg/kg) ? Farmaco, Edizione Scientifica. Vol. 14, Pg. 347, 1959.
rat LD50 intravenous 100mg/kg (100mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 665, 1960.
rat LD50 oral 245mg/kg (245mg/kg) BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 48, 1959.
rat LD50 subcutaneous 230mg/kg (230mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1285, 1972.
women TDLo oral 168mg/kg/4W-I (168mg/kg) VASCULAR: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
Archives of Internal Medicine. Vol. 145, Pg. 685, 1985.
women TDLo unreported 40mg/kg/4D-I (40mg/kg) BLOOD: LEUKOPENIA

BLOOD: AGRANULOCYTOSIS
Problemy Gematologii i Perelivaniia Krovi. Problems of Hematology and Blood Transfusion. Vol. 4(5), Pg. 48, 1959.

Safety

Hazard Codes:?Xn,T
Risk Statements: 36/37/38-20/21/22-42/43-45
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R42/43:May cause sensitization by inhalation and skin contact.?
R45:May cause cancer.
Safety Statements: 36/37/39-26-45-22-53
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S22:Do not breathe dust.?
S53:Avoid exposure - obtain special instructions before use.
RIDADR: 3249
RTECS: UQ8225000
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 50-33-9(Hazardous Substances Data)
Suspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of white blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.