Inosine (cas 58-63-9) Molecular Structure

CAS No. 58-63-9 (Inosine )

Molecular Formula: C10H12N4O5Molecular Weight: 268.23

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    DetailDesc: Inosine (CAS: 58-63-9) Item Index Molecular Formula C10H12N4O5 Molecular weight 268.23 Specification CP/USP/EP Appearance White crystalline powder Melting point 222-226 °C (dec.)(lit.) Specific rotation -49.2 º (c=1,H2O 18 ºC) Boiling point 226 C (dec.) Refractive ...

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    DetailDesc: Name Inosine Other Name beta-Inosine CAS NO. 58-63-9 Purity 99% EC NO. 200-390-4 Molecular Formula C10H12N4O5 Molecular Weight 268.23 Apperance White crystalline powder Usage cell function activator, cardiotonic

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References of Inosine cas 58-63-9

} Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM7460000
CHEMICAL NAME :
Inosine
CAS REGISTRY NUMBER :
58-63-9
LAST UPDATED :
199806
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C10-H12-N4-O5
MOLECULAR WEIGHT :
268.26
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
558 gm/kg/93D-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
60 mmol/L
REFERENCE :
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4726 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1253 (estimated) No. of Female Employees: 904 (estimated)

Safety

Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.