Vindesine Sulfate (cas 59917-39-4) Molecular Structure

CAS No. 59917-39-4 (Vindesine Sulfate )

Molecular Formula: C43H55N5O7.H2SO4Molecular Weight: 852.00458

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    DetailDesc:Name: Vindesine Sulfate Synonyms: Desacetylvinblastine amide sulfate (1:1) CAS Registry number: 59917-39-4 EINECS:261-984-7 Molecular Formula: C 43 H 55 N 5 O 7 . H 2 SO 4 Density: 1.41 g/cm 3 Appearance: Amorphous Solid Usage: Synthetic derivative of the dimeric Catharanthus alkaloid vinblastine. Antineoplastic Safety Statements: 26-36 Transport:1544

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References of Vindesine Sulfate cas 59917-39-4

} Toxicity

mouse LD50 intraperitoneal 3500ug/kg (3.5mg/kg) BEHAVIORAL: ATAXIA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
mouse LD50 intravenous 6300ug/kg (6.3mg/kg)   Journal of Toxicology and Environmental Health. Vol. 1, Pg. 843, 1976.
mouse LD50 subcutaneous 6800ug/kg (6.8mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat LD50 intraperitoneal 1050ug/kg (1.05mg/kg) BEHAVIORAL: ATAXIA
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat LD50 intravenous 1920ug/kg (1.92mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BLOOD: NORMOCYTIC ANEMIA
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.
rat LD50 subcutaneous 1790ug/kg (1.79mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 17, Pg. 1549, 1983.

Safety

Poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

Hazard codes: Xn Harmful
Risk statements: 40 Limited evidence of a carcinogenic effect. 
Safety statements: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                           36 Wear suitable protective clothing.