
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LCLo | inhalation | 76000ppm (76000ppm) | ? | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935. |
| frog | LDLo | subcutaneous | 24gm/kg (24000mg/kg) | ? | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935. |
| guinea pig | LDLo | intraperitoneal | 2gm/kg (2000mg/kg) | ? | American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974. |
| human | TCLo | inhalation | 200ppm (200ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943. |
| man | LDLo | oral | 260mg/kg (260mg/kg) | ? | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. |
| mouse | LC50 | inhalation | 31000ppm/30M (31000ppm) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Experimental Animals. Jikken Dobutso Iho. Vol. 34, Pg. 379, 1985. |
| mouse | LD50 | intraperitoneal | 2420mg/kg (2420mg/kg) | ? | Proceedings of the Western Pharmacology Society. Vol. 27, Pg. 511, 1984. |
| mouse | LD50 | intravenous | 996mg/kg (996mg/kg) | ? | Journal of Pharmaceutical Sciences. Vol. 67, Pg. 566, 1978. |
| mouse | LDLo | subcutaneous | 8mg/kg (8mg/kg) | ? | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935. |
| rabbit | LCLo | inhalation | 106000ppm (106000ppm) | ? | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935. |
| rabbit | LD50 | skin | > 20mL/kg (20mL/kg) | ? | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. |
| rat | LCLo | inhalation | 32000ppm/4H (32000ppm) | ? | American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. |
| rat | LD50 | oral | 1215mg/kg (1215mg/kg) | ? | Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971. |
Hazard Codes of Ethyl ether (CAS NO.60-29-7):?F+,Xn,T
Risk Statements: 12-19-22-66-67-39-23/24/25?
R12: Extremely flammable.?
R19: May form explosive peroxides.?
R22: Harmful if swallowed.?
R66: Repeated exposure may cause skin dryness or cracking.?
R67: Vapours may cause drowsiness and dizziness.?
R39: Danger of very serious irreversible effects.?
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 9-16-29-33-45-36/37?
S9: Keep container in a well-ventilated place.?
S16: Keep away from sources of ignition.?
S29: Do not empty into drains.?
S33: Take precautionary measures against static discharges.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37: Wear suitable protective clothing and gloves.
RIDADR: UN 1155 3/PG 1
WGK Germany: 1
RTECS: KI5775000
F: 10
HazardClass: 3
PackingGroup: I
Moderately toxic to humans by ingestion. Poison experimentally by subcutaneous route. Moderately toxic by intraperitoneal and intravenous routes. Mildly toxic by inhalation. Human systemic effects by inhalation: olfactory changes. Mutation data reported. A severe eye and moderate skin irritant. Ethyl ether is not corrosive or dangerously reactive. It must not be considered safe for individuals to inhale or ingest. It is a depressant of the central nervous system and is capable of producing intoxication, drowsiness, stupor, and unconsciousness. Death due to respiratory failure may result from severe and continued exposure.
?
A very dangerous fire and explosion hazard when exposed to heat or flame. A storage hazard. It auto-oxidizes to form explosive polymeric 1-oxy-peroxides. Explosive reaction with boron triazide, bromine trifluoride, bromine pentafluoride, perchloric acid, uranyl nitrate + light, wood pulp extracts + heat. Violent reaction or ignition on contact with halogens (e.g., bromine, chlorine), interhalogens (e.g., iodine heptafluoride), oxidants (e.g., silver perchlorate, nitrosyl perchlorate, nitryl perchlorate, chromyl chloride, fluorine nitrate, permanganic acid, nitric acid, hydrogen peroxide, peroxodisulfuric acid, iodine(VII) oxide, sodium peroxide, ozone, and liquid air), sulfur and sulfur compounds (e.g., sulfur when dried with peroxidized ether, sulfuryl chloride). Can react vigorously with acetyl peroxide, air, bromoazide, ClF3, CrO3, Cr(OCl)2, LiAlH2, NOClO4, O2, NClO2, (H2SO4 + permanganates), K2O2, [(C2H5)3Al + air], [(CH3)3Al + air]. To fight fire, use alcohol foam, CO2, dry chemical. Used in production of drugs of abuse. When heated to decomposition it emits acrid smoke and irritating fumes. See also ETHERS.