Lipoic acid (cas 62-46-4) Molecular Structure

CAS No. 62-46-4 (Lipoic acid )

Molecular Formula: C8H14O2S2Molecular Weight: 206.32

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References of Lipoic acid cas 62-46-4

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 160mg/kg (160mg/kg) ? Drugs in Japan Vol. 6, Pg. 454, 1982.
mouse LD50 intravenous 197mg/kg (197mg/kg) ? Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 278, 1964.
mouse LD50 oral 502mg/kg (502mg/kg) ? Archives of Toxicology. Vol. 41, Pg. 79, 1978.
mouse LD50 subcutaneous 200mg/kg (200mg/kg) ? Drugs in Japan Vol. 6, Pg. 454, 1982.
rat LD50 intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68, Pg. 265, 1972.
rat LD50 intravenous 180mg/kg (180mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68, Pg. 265, 1972.
rat LD50 oral 1130mg/kg (1130mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68, Pg. 265, 1972.
rat LD50 subcutaneous 230mg/kg (230mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68, Pg. 265, 1972.

Safety

WGK Germany of Lipoic acid (CAS NO.62-46-4): 3
Since the early 1990s lipoic acid has been consumed as a dietary supplement, typical doses are 100–200 mg/day. A chronic/carcinogenicity study in rats reported that racemic lipoic acid was found to be non-carcinogenic and did not show any evidence of target organ toxicity. The NOAEL is considered to be 60 mg/kg bw/day.