Colchicine (cas 64-86-8) Molecular Structure

CAS No. 64-86-8 (Colchicine )

Molecular Formula: C22H25NO6Molecular Weight: 399.44

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References of Colchicine cas 64-86-8

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 31600ug/kg (31.6mg/kg) ? Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LD50 intravenous 250ug/kg (0.25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 106, Pg. 261, 1952.
cat LDLo oral 125ug/kg (0.125mg/kg) ? "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
cat LDLo subcutaneous 500ug/kg (0.5mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1337, 1935.
child TDLo parenteral 2400ug/kg (2.4mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
Veterinary and Human Toxicology. Vol. 37, Pg. 366, 1995.
dog LDLo oral 125ug/kg (0.125mg/kg) ? "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
dog LDLo subcutaneous 571ug/kg (0.571mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1337, 1935.
dog LDLo unreported 5mg/kg (5mg/kg) ? Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 27, Pg. 119, 1890.
gerbil LD50 intraperitoneal 90mg/kg (90mg/kg) ? Medicina et Pharmacologia Experimentalis. Vol. 17, Pg. 323, 1967.
guinea pig LD50 intraperitoneal 500ug/kg (0.5mg/kg) ? Medicina Experimentalis. Vol. 6, Pg. 101, 1962.
guinea pig LDLo oral 12500ug/kg (12.5mg/kg) LIVER: OTHER CHANGES

BLOOD: CHANGES IN SPLEEN

BLOOD: OTHER CHANGES
Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. Vol. 320, Pg. 93, 1951.
hamster LD50 intraperitoneal 7300ug/kg (7.3mg/kg) ? Medicina Experimentalis. Vol. 6, Pg. 101, 1962.
human LDLo intravenous 129ug/kg (0.129mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

VASCULAR: SHOCK

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Human Toxicology. Vol. 2, Pg. 169, 1983.
human LDLo oral 86ug/kg (0.086mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: OTHER CHANGES
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 184, 1969.
human TDLo parenteral 710ug/kg (0.71mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

GASTROINTESTINAL: NAUSEA OR VOMITING
Archives of Internal Medicine. Vol. 137, Pg. 394, 1977.
man LDLo intravenous 143ug/kg/5D-I (0.143mg/kg) BLOOD: APLASTIC ANEMIA

MUSCULOSKELETAL: OTHER CHANGES
New England Journal of Medicine. Vol. 309, Pg. 310, 1983.
man LDLo oral 11mg/kg (11mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Canadian Medical Association Journal. Vol. 138, Pg. 335, 1988.
man TDLo oral 400ug/kg (0.4mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"
Critical Care Medicine. Vol. 7, Pg. 278, 1979.
man TDLo oral 12514ug/kg/2Y (12.514mg/kg) BEHAVIORAL: MUSCLE WEAKNESS New England Journal of Medicine. Vol. 316, Pg. 1562, 1987.
mouse LD50 intramuscular 1197ug/kg (1.197mg/kg) ? Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981.
mouse LD50 intraperitoneal 1600ug/kg (1.6mg/kg) ? Journal of Medicinal Chemistry. Vol. 28, Pg. 1204, 1985.
mouse LD50 intravenous 1700ug/kg (1.7mg/kg) ? Drugs in Japan Vol. 6, Pg. 280, 1982.
mouse LD50 oral 5886ug/kg (5.886mg/kg) ? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 subcutaneous 1200ug/kg (1.2mg/kg) ? Drugs in Japan Vol. 6, Pg. 280, 1982.
pigeon LDLo unreported 30mg/kg (30mg/kg) ? Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 27, Pg. 119, 1890.
quail LD50 oral 42mg/kg (42mg/kg) ? Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
rabbit LDLo intravenous 3mg/kg (3mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 67, Pg. 768, 1909.
rabbit LDLo oral 50mg/kg (50mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 67, Pg. 768, 1909.
rabbit LDLo subcutaneous 5mg/kg (5mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 67, Pg. 768, 1909.
rat LD50 intravenous 1600ug/kg (1.6mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 13, Pg. 50, 1968.
rat LDLo intracrebral 1mg/kg (1mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LDLo intraperitoneal 1400ug/kg (1.4mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

MUSCULOSKELETAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Archives of Neurology Vol. 24, Pg. 72, 1971.
rat LDLo parenteral 1000ug/kg (1mg/kg) ? Farmaco, Edizione Scientifica. Vol. 15, Pg. 533, 1960.
rat LDLo subcutaneous 4mg/kg (4mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 257, 1950.
rat LDLo unreported 1mg/kg (1mg/kg) ? "Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
women LDLo intravenous 360ug/kg/6D (0.36mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BLOOD: HEMORRHAGE
Nouvelle Presse Medicale. Vol. 9, Pg. 1587, 1980.
women LDLo oral 600ug/kg (0.6mg/kg) CARDIAC: OTHER CHANGES

BLOOD: APLASTIC ANEMIA
American Journal of Emergency Medicine. Vol. 16, Pg. 603, 1998.
women LDLo oral 3mg/kg (3mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Japanese Journal of Toxicology. Vol. 12, Pg. 337, 1999.
women LDLo oral 8360ug/kg (8.36mg/kg) CARDIAC: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Analytical Toxicology. Vol. 4, Pg. 153, 1980.
women TDLo oral 320ug/kg (0.32mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Lancet. Vol. 2, Pg. 1271, 1987.
women TDLo oral 510ug/kg (0.51mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: APLASTIC ANEMIA
Human & Experimental Toxicology. Vol. 16, Pg. 229, 1997.
women TDLo oral 960ug/kg (0.96mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP New England Journal of Medicine. Vol. 322, Pg. 642, 1995.
women TDLo oral 1mg/kg (1mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BLOOD: LEUKOPENIA
Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 71, 1995.
women TDLo oral 4368ug/kg/26W (4.368mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Neurology. Vol. 41, Pg. 943, 1991.
?

Safety

A human poison by ingestion and intravenous routes. Poison experimentally by most routes. Human systemic effects: aplastic anemia, blood pressure depression, body temperature decrease, changes in kidney tubules, dyspnea, flaccid paralysis without anesthesia, gastrointestinal effects, kidney damage and hemorrhaging, muscle contraction or spasticity, muscle weakness, nausea or vomiting, respiratory stimulation, and somnolence. An experimental teratogen. Experimental reproductive effects. A severe eye irritant. Human mutation data reported. Inhibits the formation of microtubules and thus impairs cell division. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?T+,T
Risk Statements: 26/28?
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements: 13-45?
S13:Keep away from food, drink and animal foodstuffs.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1544 6.1/PG 1
WGK Germany: 3
RTECS: GH0700000
HazardClass: 6.1
PackingGroup: I