Cefotaxime sodium (cas 64485-93-4) Molecular Structure

CAS No. 64485-93-4 (Cefotaxime sodium )

Molecular Formula: C16H16N5NaO7S2Molecular Weight: 477.44731

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References of Cefotaxime sodium cas 64485-93-4

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 1800mg/kg/18D (1800mg/kg) BLOOD: AGRANULOCYTOSIS Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 739, 1983.
dog LD50 intramuscular > 716mg/kg (716mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
dog LD50 intravenous > 1500mg/kg (1500mg/kg) ? Journal of Antimicrobial Chemotherapy. Vol. 6(Suppl,
mouse LD50 intraperitoneal 10gm/kg (10000mg/kg) ? Drugs in Japan Vol. 6, Pg. APP-8, 1982.
mouse LD50 intravenous 6845mg/kg (6845mg/kg) ? Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 35(5), Pg. 25, 1990.
mouse LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: ATAXIA
Chemotherapy Vol. 28(Suppl,
mouse LD50 subcutaneous 12950mg/kg (12950mg/kg) ? Drugs in Japan Vol. 6, Pg. APP-8, 1982.
rabbit LD50 intravenous 1880mg/kg (1880mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: ATAXIA
Chemotherapy Vol. 28(Suppl,
rat LD50 intramuscular > 2gm/kg (2000mg/kg) ? Chemotherapy Vol. 28(Suppl,
rat LD50 intraperitoneal 10gm/kg (10000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BEHAVIORAL: ATAXIA
Chemotherapy Vol. 28(Suppl,
rat LD50 intravenous 7gm/kg (7000mg/kg) ? Drugs in Japan Vol. 6, Pg. APP-8, 1982.
rat LD50 oral > 20gm/kg (20000mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemotherapy Vol. 28(Suppl,
rat LD50 subcutaneous 18400mg/kg (18400mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemotherapy Vol. 28(Suppl,

Safety

Moderately toxic by intravenous and intramuscular routes. Mildly toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: agranulocytosis. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx, NOx and Na2O.
Hazard Codes:?HarmfulXn,IrritantXi(Harmful)
Risk Statements:
R42/43 (May cause sensitization by inhalation and skin contact )
Safety Statements:
S22:Do not breathe dust??
S36/37 :Wear suitable protective clothing and gloves
WGK Germany: 2