Ranitidine (cas 66357-35-5) Molecular Structure

CAS No. 66357-35-5 (Ranitidine )

Molecular Formula: C13H22N4O3SMolecular Weight: 350.87

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References of Ranitidine cas 66357-35-5

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 4286ug/kg/2D- (4.286mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 17, Pg. 258, 1999.
man TDLo oral 60mg/kg/14D-I (60mg/kg) LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: LIVER FUNCTION TESTS IMPAIRED

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of Gastroenterology. Vol. 93, Pg. 822, 1998.
mouse LD50 intramuscular 280mg/kg (280mg/kg) ? United States Patent Document. Vol. #4613602,
mouse LD50 intravenous 80mg/kg (80mg/kg) ? United States Patent Document. Vol. #4613602,
mouse LD50 oral 884mg/kg (884mg/kg) ? European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 749, 1990.
rat LD50 intramuscular 2018mg/kg (2018mg/kg) ? United States Patent Document. Vol. #4613602,
rat LD50 intravenous 93mg/kg (93mg/kg) ? United States Patent Document. Vol. #4613602,
rat LD50 oral > 5gm/kg (5000mg/kg) ? United States Patent Document. Vol. #4613602,
women TDLo oral 12mg/kg/2D-I (12mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

BLOOD: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE"
American Journal of Emergency Medicine. Vol. 12, Pg. 67, 1994.

Safety

Safety Statements: 22-24/25?
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: KM6557000