Phosphonic difluoride,P-methyl- (cas 676-99-3) Molecular Structure

CAS No. 676-99-3 (Phosphonic difluoride,P-methyl- )

Molecular Formula: CH3 F2 O PMolecular Formula: 100.01

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References of Phosphonic difluoride,P-methyl- cas 676-99-3

} Toxicity

The toxicity of Methylphosphonyl difluoride (CAS NO.676-99-3):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LCLo inhalation 1842mg/m3/30M (1842mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
dog LD50 intravenous 25800ug/kg (25.8mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
guinea pig LCLo inhalation 1600mg/m3 (1600mg/m3)   Toxicologist. Vol. 4, Pg. 22, 1984.
monkey LCLo inhalation 2608mg/m3/30M (2608mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

BEHAVIORAL: AGGRESSION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
monkey LD50 intravenous 26900ug/kg (26.9mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LCLo inhalation 1842mg/m3/30M (1842mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
mouse LD50 intravenous 114mg/kg (114mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
rat LCLo inhalation 1842mg/m3/30M (1842mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Toxicology and Applied Pharmacology. Vol. 15, Pg. 131, 1969.
rat LD50 intravenous 13700ug/kg (13.7mg/kg)   Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,

Safety

The Risk Statements Methylphosphonyl difluoride (CAS NO.676-99-3):
R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:S23:Do not breathe vapour. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
Poison by inhalation and intravenous routes. When heated to decomposition it emits toxic fumes of POx and F. See also FLUORIDES.