Norfloxacin (cas 70458-96-7) Molecular Structure

CAS No. 70458-96-7 (Norfloxacin )

Molecular Formula: C16H18FN3O3Molecular Weight: 319.330823

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References of Norfloxacin cas 70458-96-7

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 oral > 4gm/kg (4000mg/kg) ? Journal of Medicinal Chemistry. Vol. 32, Pg. 671, 1989.
man TDLo oral 94mg/kg/13D-I (94mg/kg) MUSCULOSKELETAL: OTHER CHANGES New Zealand Medical Journal. Vol. 96, Pg. 590, 1983.
mouse LD50 intramuscular 470mg/kg (470mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Chemotherapy Vol. 29(Suppl,
mouse LD50 intraperitoneal 1064mg/kg (1064mg/kg) ? Ensho. Japanese Journal of Inflammation. Vol. 11, Pg. 343, 1991.
mouse LD50 intravenous 220mg/kg (220mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 29(Suppl,
mouse LD50 oral 4gm/kg (4000mg/kg) ? Journal of Medicinal Chemistry. Vol. 30, Pg. 2163, 1987.
mouse LD50 subcutaneous > 1500mg/kg (1500mg/kg) ? Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
rat LD50 intramuscular > 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemotherapy Vol. 29(Suppl,
rat LD50 intravenous 245mg/kg (245mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemotherapy Vol. 29(Suppl,
rat LD50 oral > 4gm/kg (4000mg/kg) ? Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
rat LD50 subcutaneous > 1500mg/kg (1500mg/kg) ? Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
women TDLo oral 48mg/kg/2D-I (48mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: LIVER FUNCTION TESTS IMPAIRED
Medical Journal of Australia. Vol. 159, Pg. 423, 1993.
women TDLo oral 48mg/kg/2D-I (48mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

BEHAVIORAL: MUSCLE WEAKNESS

MUSCULOSKELETAL: JOINTS
Medical Journal of Australia. Vol. 159, Pg. 423, 1993.

Safety

Hazard Codes:?HarmfulXn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: VB2005000