CAS No. 82419-36-1 (Ofloxacin )
Molecular Formula: C18H20FN3O4Molecular Weight: 361.367503
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Wide Usage of Ofloxacin(CAS No. 82419-36-1)
Ofloxacin(CAS No. 82419-36-1) is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generationfluoroquinolone. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops.
Ofloxacin (CAS No. 82419-36-1) is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin. When levofloxacin disks were not available in early clinical trials, a 5-pg ofloxacin disk was substituted. The U.S. Food and Drug Administration (FDA) medical reviewers considered the two drugs to be one and the same and hence interchangeable.
Like other quinolones, ofloxacin(CAS No. 82419-36-1) has been associated with a significant number of serious adverse drug reactions, such as tendondamage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); such reactions may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities. Ofloxacin has also been associated with severe psychiatric adverse reactions.
In the adult population ofloxacin(CAS No. 82419-36-1) is limited to the treatment of proven serious and life threatening bacterial infections such as:
1.Acute bacterial exacerbations of chronic bronchitis;
3.Uncomplicated skin and skin structure infections;
4.Nongonococcal urethritis and cervicitis;
5.Mixed Infections of the urethra and cervix;
6.Acute pelvic inflammatory disease;
8.Complicated urinary tract infections;
10.Acute, uncomplicated urethral and cervical gonorrhea.
Ofloxacin(CAS No. 82419-36-1) has not been shown to be effective in the treatment of syphilis. Floxin is now considered to be contraindicated for the treatment of certain sexually transmitted diseases by some experts due to bacterial resistance.