1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl- (cas 83-67-0) Molecular Structure

CAS No. 83-67-0 (1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl- )

Molecular Formula: C7H8N4O2Molecular Weight: 180.16

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References of 1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl- cas 83-67-0

} Toxicity

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

cat

LD50

oral

200mg/kg (200mg/kg)

 

"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1372, 1986.

dog

LD50

oral

300mg/kg (300mg/kg)

 

Toxicology and Applied Pharmacology. Vol. 53, Pg. 481, 1980.

human

TDLo

oral

26mg/kg (26mg/kg)

behavioral: changes in motor activity (specific assay)
gastrointestinal: nausea or vomiting

Journal of Pharmacology and Experimental Therapeutics. Vol. 86, Pg. 113, 1946.

mouse

LD50

intraperitoneal

552mg/kg (552mg/kg)

behavioral: convulsions or effect on seizure threshold

Acta Pharmaceutica Vol. 46, Pg. 93, 1996.

mouse

LD50

oral

837mg/kg (837mg/kg)

 

Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(3), Pg. 59, 1982.

mouse

LD50

subcutaneous

530mg/kg (530mg/kg)

 

Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956.

rabbit

LDLo

subcutaneous

1gm/kg (1000mg/kg)

 

"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

rat

LD50

oral

1265mg/kg (1265mg/kg)

 

Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(3), Pg. 59, 1982.

Safety

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Risk Codes : 22
22: Theobromine (83-67-0) is harmful if swallowed  
Safety Description : 22-24/25
22:  Do not breathe dust
24/25:  Avoid contact with skin and eyes