isosorbide dinitrate (cas 87-33-2) Molecular Structure

CAS No. 87-33-2 (isosorbide dinitrate )

Molecular Formula: C6H8N2O8Molecular Weight: 236.14

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References of isosorbide dinitrate cas 87-33-2

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 1109mg/kg (1109mg/kg)   French Demande Patent Document. Vol. #2454807,
man TDLo oral 1714ug/kg/3D- (1.714mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 596, 1997.
mouse LD50 intramuscular 1080mg/kg (1080mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse LD50 intraperitoneal 720mg/kg (720mg/kg)   Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse LD50 intravenous > 40mg/kg (40mg/kg) BEHAVIORAL: ATAXIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
mouse LD50 oral 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
mouse LD50 subcutaneous 1050mg/kg (1050mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
rabbit LD50 intravenous > 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat LD50 intramuscular > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. 6, Pg. 72, 1982.
rat LD50 intraperitoneal 670mg/kg (670mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat LD50 intravenous > 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4947, 1985.
rat LD50 oral 747mg/kg (747mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 309, 1984.
rat LD50 skin > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 35, Pg. 287, 1988.
rat LD50 subcutaneous 1237mg/kg (1237mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 2109, 1982.
women TDLo oral 100ug/kg (0.1mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE

CARDIAC: OTHER CHANGES
Southern Medical Journal. Vol. 84, Pg. 369, 1991.
 

Safety

Moderately toxic by ingestion, intraperitoneal, intramuscular, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits toxic fumes of NOx. A coronary vasodilator.
Hazard Codes: HarmfulXn
Risk Statements: 5-22
R5 :Heating may cause an explosion. 
R22:Harmful if swallowed.
Safety Statements: 36 
S36:Wear suitable protective clothing.
RIDADR: UN 2907
HazardClass: 1.1A
PackingGroup: II