5-Aminosalicylic acid (cas 89-57-6) Molecular Structure

CAS No. 89-57-6 (5-Aminosalicylic acid )

Molecular Formula: C7H7NO3Molecular Weight: 153.14

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References of 5-Aminosalicylic acid cas 89-57-6

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 51mg/kg/5D-I (51mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Lancet. Vol. 1, Pg. 917, 1984.
man TDLo oral 321mg/kg/15D- (321mg/kg) SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE American Journal of Gastroenterology. Vol. 94, Pg. 3386, 1999.
man TDLo oral 2057mg/kg/17W (2057mg/kg) BLOOD: AGRANULOCYTOSIS Lancet. Vol. 341, Pg. 1476, 1993.
man TDLo oral 6857mg/kg/17W (6857mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: "JAUNDICE, CHOLESTATIC"
Journal of Hepathology. Vol. 26, Pg. 425, 1997.
monkey LDLo oral 3gm/kg (3000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: HEMATURIA
Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 509, 1994.
mouse LD50 intraperitoneal 469mg/kg (469mg/kg) ? Archiv der Pharmazie Vol. 332, Pg. 321, 1999.
mouse LD50 oral 3370mg/kg (3370mg/kg) ? Archiv der Pharmazie Vol. 332, Pg. 321, 1999.
rabbit LD50 skin > 5gm/kg (5000mg/kg) ? National Technical Information Service. Vol. OTS0570511,
rat LD50 intraperitoneal 1gm/kg (1000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 505, 1994.
rat LD50 oral 2800mg/kg (2800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: OTHER CHANGES
National Technical Information Service. Vol. OTS0570511,
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: HEADACHE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Lancet. Vol. 1, Pg. 917, 1984.
women TDLo oral 80mg/kg/1D-I (80mg/kg) CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Gastroenterology. Vol. 93, Pg. 470, 1998.
women TDLo oral 5400mg/kg/90D (5400mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS American Journal of Gastroenterology. Vol. 92, Pg. 2302, 1997.
women TDLo oral 8760mg/kg/1Y- (8760mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

BEHAVIORAL: MUSCLE WEAKNESS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Clinical Nephrology. Vol. 49, Pg. 265, 1998.
women TDLo oral 21800mg/kg/39 (21800mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BLOOD: EOSINOPHILIA
American Journal of Gastroenterology. Vol. 91, Pg. 1039, 1996.

Safety

Poison by intraperitoneal route. Moderately toxic by ingestion. Human systemic effects by ingestion: hypermotility, diarrhea, dermatitis, increased body temperature. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of 5-Aminosalicylic acid (CAS NO.89-57-6).
Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: VO1400000
F: 8-10-23
Hazard Note: Irritant
HS Code: 29225000