Sodium Hyaluronate (cas 9067-32-7) Molecular Structure

CAS No. 9067-32-7 (Sodium Hyaluronate )

Molecular Formula: C28H44N2O23?NaMolecular Weight: 799.6366

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References of Sodium Hyaluronate cas 9067-32-7

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous > 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse LD50 intraperitoneal 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 1013, 1984.
mouse LD50 oral > 2400mg/kg (2400mg/kg) ? Drugs in Japan Vol. -, Pg. 849, 1990.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 intraperitoneal 1820mg/kg (1820mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 oral > 1gm/kg (1000mg/kg) ? Drugs in Japan Vol. -, Pg. 849, 1990.
rabbit LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 intraperitoneal 1770mg/kg (1770mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 oral > 800mg/kg (800mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

Safety

Hazard Codes:?BiohazardB,IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-27-26?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S27:Take off immediately all contaminated clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: MT7250000
F: 3-10
Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Na2O.