Phencyclidine hydrochloride (cas 956-90-1) Molecular Structure

CAS No. 956-90-1 (Phencyclidine hydrochloride )

Molecular Formula: C17H25N•ClHMolecular Weight: 279.89

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References of Phencyclidine hydrochloride cas 956-90-1

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 5600ug/kg (5.6mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
dog LDLo intravenous 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CHANGE IN RATE

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Toxicology. Vol. 19, Pg. 11, 1981.
duck LD50 oral 75mg/kg (75mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
human LDLo oral 14mg/kg (14mg/kg) BEHAVIORAL: COMA JAMA, Journal of the American Medical Association. Vol. 238, Pg. 515, 1977.
human TDLo intravenous 10ug/kg (0.01mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Canadian Psychiatric Association Journal. Vol. 6, Pg. 150, 1961.
human TDLo oral 71ug/kg (0.071mg/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT
JAMA, Journal of the American Medical Association. Vol. 238, Pg. 515, 1977.
mouse LD50 intraperitoneal 59558ug/kg (59.558mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA
Substance and Alcohol Actions/Misuse. Vol. 2, Pg. 143, 1981.
mouse LD50 intravenous 16mg/kg (16mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Life Sciences. Vol. 31, Pg. 803, 1982.
mouse LD50 oral 77mg/kg (77mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 28, Pg. 713, 1976.
mouse LD50 subcutaneous 43mg/kg (43mg/kg)   Journal of Medicinal Chemistry. Vol. 24, Pg. 496, 1981.
pigeon LD50 oral 237mg/kg (237mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat LD50 oral 135mg/kg (135mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Neurobehavioral Toxicology and Teratology. Vol. 3, Pg. 11, 1981.

Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion and intravenous routes: distorted perceptions, euphoria, excitement, hallucinations, and paresthesia. An experimental teratogen. Other experimental reproductive effects. Often mixed with other drugs of abuse yielding totally unpredictable effects. A controlled substance. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Hazard Codes: ToxicT
Risk Statements: 25
R25: Toxic if swallowed.
Safety Statements: 36/37-45
S36/37: Wear suitable protective clothing and gloves. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TN2272600
HazardClass: 6.1(a)
PackingGroup: I