?8-Hydroxyquinoline (CAS NO.148-24-3) is a white to off-white or
faintly yellow crystalline powder with phenolic odor.It
is?insoluble in water. 8-Hydroxyquinoline darkens on exposure to
light and readily forms stable metal chelates. It is incompatible
with strong oxidizers and it is also incompatible with many metal
It? is a monoprotic bidentate chelating agent. Related ligands are the Schiff bases derived from salicylaldehyde, such as salicylaldoxime and salen. In neutral solution, the hydroxyl is in the protonated form (pKa=9.89) and the nitrogen is not protonated (pKa=5.13).However, an excited-state zwitterionic isomer exists in which H+ is transfered from the oxygen (giving an oxygen anion) to the nitrogen (giving a protonated nitrogen cation).
R22:Harmful if swallowed.?
R68:Possible risk of irreversible effects.?
R36/37/38:Irritating to eyes, respiratory system and skin.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Harmful/Irritant
HS Code: 29334990
|Organism||Test Type||Route||Reported Dose (Normalized Dose)||Effect||Source|
|guinea pig||LD20||oral||1205mg/kg (1205mg/kg)||?||Teratology, The International Journal of Abnormal Development. Vol. 20, Pg. 413, 1979.|
|mammal (species unspecified)||LD50||unreported||1gm/kg (1000mg/kg)||?||"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 410, 1971.|
|mouse||LD50||intraperitoneal||43mg/kg (43mg/kg)||?||Farmakologiya i Toksikologiya Vol. 42, Pg. 396, 1979.|
|mouse||LD50||oral||20gm/kg (20000mg/kg)||?||Drugs in Japan Vol. 6, Pg. 271, 1982.|
|mouse||LD50||subcutaneous||83600ug/kg (83.6mg/kg)||?||Pharmazie. Vol. 1, Pg. 150, 1946.|
|rat||LC50||inhalation||> 1210mg/m3/6H (1210mg/m3)||?||Journal of the American College of Toxicology. Vol. 11, Pg. 497, 1992.|
|rat||LD50||oral||1200mg/kg (1200mg/kg)||?||Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 602, 1966.|