Ipratropium bromide (cas 22254-24-6) MSDS

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1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name
:
Ipratropium bromide monohydrate
2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
According to Regulation (EC) No1272/2008
Acute toxicity, Inhalation (Category 4)
Acute toxicity, Oral (Category 4)
Eye irritation (Category 2)
According to European Directive 67/548/EEC as amended.
Harmful by inhalation and if swallowed. Irritating to eyes.
Label elements
Pictogram
Signal word
Hazard statement(s)
H302
H319
H332
Precautionary statement(s)
P305 + P351 + P338
Warning
Harmful if swallowed.
Causes serious eye irritation.
Harmful if inhaled.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
Hazard symbol(s)
Xn
R-phrase(s)
R20/22
R36
S-phrase(s)
S26
Harmful
Harmful by inhalation and if swallowed.
Irritating to eyes.
In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice.
Other hazards - none
3. COMPOSITION/INFORMATION ON INGREDIENTS
Synonyms
Formula
Molecular Weight
:
:
:
Atropine isopropyl bromide
C20H30BrNO3 · H2O
430,38 g/mol
CAS-No.
EC-No.
Classification
Concentration
Ipratropium bromide
66985-17-9
244-873-8
-
Acute Tox. 4; Eye Irrit. 2; H302,
-
H319, H332
Xn, R20/22 - R36
For the full text of the H-Statements mentioned in this Section, see Section 16.
4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.
7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire
protection.
Conditions for safe storage
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type
P1 (EN 143) respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Hand protection
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard
EN 374 derived from it.
Handle with gloves.
Eye protection
Face shield and safety glasses
Skin and body protection
Choose body protection according to the amount and concentration of the dangerous substance at the work
place.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the
end of workday.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form
Colour
Safety data
pH
Melting point
Boiling point
Flash point
Ignition temperature
Lower explosion limit
Upper explosion limit
Water solubility
powder
white
no data available
229 - 231 °C
no data available
no data available
no data available
no data available
no data available
no data available
10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Conditions to avoid
no data available
Materials to avoid
Oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx),
hydrogen bromide gas
11. TOXICOLOGICAL INFORMATION
Acute toxicity
LD50 Oral - rat - 1.663 mg/kg
Remarks: Behavioral:Ataxia. Behavioral:Convulsions or effect on seizure threshold.
LD50 Oral - mouse - 1.001 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold. Behavioral:Ataxia. Lungs, Thorax, or
Respiration:Dyspnea.
LD50 Oral - rabbit - 1.557 mg/kg
Remarks: Behavioral:Tremor. Behavioral:Ataxia. Lungs, Thorax, or Respiration:Dyspnea.
LD50 Oral - dog - 1.300 mg/kg
Inhalation: no data available
LD50 Intraperitoneal - rat - 113 mg/kg
Remarks: Behavioral:Ataxia. Behavioral:Tetany. Lungs, Thorax, or Respiration:Dyspnea.
LD50 Subcutaneous - rat - 72 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold. Behavioral:Coma.
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes - rabbit - Moderate eye irritation - 24 h
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable,
possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
Harmful if inhaled. May cause respiratory tract irritation.
Harmful if swallowed.
May be harmful if absorbed through skin. May cause skin irritation.
Causes eye irritation.
Signs and Symptoms of Exposure
bronchodilation, nervousness, muscle tremors, Headache, tachycardia, Palpitation, Drowsiness, Nausea, Vomiting,
Sweating, dry mouth, dryness of the respiratory passages, Sensitivity to light, change in heart rate, delirium, To the
best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Additional Information
RTECS: Not available
12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
no data available
13. DISPOSAL CONSIDERATIONS
Product
Observe all federal, state, and local environmental regulations. Contact a licensed professional waste disposal
service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
ADR/RID
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
16. OTHER INFORMATION
Text of H-code(s) and R-phrase(s) mentioned in Section 3
Acute Tox.
Eye Irrit.
H302
H319
H332
Xn
R20/22
R36
Acute toxicity
Eye irritation
Harmful if swallowed.
Causes serious eye irritation.
Harmful if inhaled.
Harmful
Harmful by inhalation and if swallowed.
Irritating to eyes.
Further information
The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. guidechem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.