Estra-1,3,5(10)-triene-3,17-diol(17b)- (cas 50-28-2) MSDS

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1.
1.1
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product identifiers
Product name
Product Number
Brand
CAS-No.
:
:
:
:
Estradiol
E1024
1.2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses
:
Laboratory chemicals, Manufacture of substances
2.
2.1
2.2
HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Carcinogenicity (Category 2)
Reproductive toxicity (Category 1A)
Effects on or via lactation
Classification according to EU Directives 67/548/EEC or 1999/45/EC
May impair fertility. Limited evidence of a carcinogenic effect. Possible risk of harm to the unborn child. May
cause harm to breastfed babies.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word
Hazard statement(s)
H351
H360Fd
H362
Precautionary statement(s)
P201
P263
P281
- E1024
Danger
Suspected of causing cancer.
May damage fertility. Suspected of damaging the unborn child.
May cause harm to breast-fed children.
Obtain special instructions before use.
Avoid contact during pregnancy/ while nursing.
Use personal protective equipment as required.
P308 + P313
Supplemental Hazard
IF exposed or concerned: Get medical advice/ attention.
none
Statements
Restricted to professional users.
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R60
R40
R63
R64
S-phrase(s)
S45
S53
Restricted to professional users.
May impair fertility.
Limited evidence of a carcinogenic effect.
Possible risk of harm to the unborn child.
May cause harm to breastfed babies.
In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Avoid exposure - obtain special instructions before use.
2.3
3.
3.1
Other hazards - none
COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms
Formula
Molecular Weight
Component
Estradiol
:
:
:
3,17β -Dihydroxy-1,3,5(10)-estratriene
β -Estradiol
1,3,5-Estratriene- 3,17β -diol
Dihydrofolliculin
17β -Estradiol
C18H24O2
272,38 g/mol
Concentration
CAS-No.
EC-No.
200-023-8
-
4.
4.1
FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
- E1024
4.2
4.3
5.
5.1
5.2
5.3
5.4
6.
6.1
6.2
6.3
6.4
7.
7.1
7.2
7.3
8.
8.1
8.2
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Indication of any immediate medical attention and special treatment needed
no data available
FIRE-FIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available
ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE
Precautions for safe handling
Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid formation of
dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.
- E1024
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
9.
9.1
PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a)
b)
c)
d)
e)
f)
g)
h)
Appearance
Odour
Odour Threshold
pH
Melting point/freezing
point
Initial boiling point and
boiling range
Flash point
Evaporation rate
Form: powder
Colour: white
no data available
no data available
no data available
Melting point/range: 176 - 180 °C - lit.
no data available
no data available
no data available
i)
Flammability (solid, gas) no data available
j)
k)
l)
Upper/lower
flammability or
explosive limits
Vapour pressure
Vapour density
no data available
no data available
no data available
m) Relative density
no data available
n)
o)
p)
q)
Water solubility
Partition coefficient: n-
octanol/water
Autoignition
temperature
Decomposition
temperature
no data available
no data available
no data available
no data available
- E1024
r)
s)
t)
Viscosity
Explosive properties
Oxidizing properties
no data available
no data available
no data available
9.2
10.
10.1
10.2
10.3
10.4
10.5
10.6
11.
11.1
Other safety information
no data available
STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
Genotoxicity in vitro - rat - Other cell types
DNA damage
Genotoxicity in vivo - rat - Oral
Morphological transformation.
Carcinogenicity
The National Toxicology Program (Tenth Report on Carcinogens) has determined that steroidal estrogens
are known to be human carcinogens based on sufficient evidence of carcinogenicity in humans, which
indicates a causal relationship between exposure to steroidal estrogens and human cancer. This is or
contains a component that has been reported to be carcinogenic based on its IARC, OSHA, ACGIH, NTP, or
EPA classification.
Suspected human carcinogens
IARC:
No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Suspected human reproductive toxicant Damage to fetus cannot be excluded.
- E1024
Known human reproductive toxicant Effects on or via lactation May damage fertility. Suspected of damaging
the unborn child.
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
May be harmful if inhaled. May cause respiratory tract irritation.
May be harmful if swallowed.
May be harmful if absorbed through skin. May cause skin irritation.
May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Additional Information
RTECS: KG2975000
12.
12.1
ECOLOGICAL INFORMATION
Toxicity
Toxicity to fish
LC50 - Oncorhynchus mykiss (rainbow trout) - > 0,5 mg/l - 96 h
12.2
12.3
12.4
12.5
12.6
13.
13.1
14.
14.1
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION
UN number
ADR/RID: -
14.2
UN proper shipping name
ADR/RID:
Not dangerous goods
IMDG:
Not dangerous goods
IATA:
Not dangerous goods
14.3
Transport hazard class(es)
ADR/RID: -
- E1024
IMDG: -
IMDG: -
IATA: -
IATA: -
14.4
Packaging group
14.5
14.6
15.
ADR/RID: -
Environmental hazards
ADR/RID: no
Special precautions for user
no data available
REGULATORY INFORMATION
IMDG: -
IMDG Marine pollutant: no
IATA: -
IATA: no
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1
15.2
16.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available
OTHER INFORMATION
Further information
The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. guidechem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.