Iron dextran (cas 9004-66-4) MSDS

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MSDS   :
  Imferon
 
  
 CAS   
:
  9004-66-4 
 SYNONYMS   
:
  * A 100
 
 * A 100 (Pharmaceutical)
 
 * B 75
 
 * Chinofer
 
 * Dextran iron complex
 
 * Dextrofer 75
 
 * Eisendextran
 
 * Fe-Dextran
 
 * Fenate
 
 * Ferdex 100
 
 * Ferric dextran
 
 * Ferridextran
 
 * Ferrodextran
 
 * Ferroglucin
 
 * Ferroglukin 75
 
 * Imposil
 
 * Iro-Jex
 
 * Iron dextran
 
 * Iron-dextran complex
 
 * Iron dextran injection
 
 * Iron hydrogenated dextran
 
 * Ironorm injection
 
 * Myofer 100
 
 * Polyfer
 
 * Prolongal
 
 * RCRA waste number U139
 
 * Ursoferran
 
 
 
  
Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers
[ Imferon 9004-66-4 ]
  
                      *** CHEMICAL IDENTIFICATION ***
 
 
 
 RTECS NUMBER            : NI2200000
 
 CHEMICAL NAME           : Imferon
 
 CAS REGISTRY NUMBER     : 9004-66-4
 
 OTHER CAS REGISTRY NOS. : 8050-93-9
 
                           53858-58-5
 
 LAST UPDATED            : 199806
 
 DATA ITEMS CITED        : 35
 
 COMPOUND DESCRIPTOR     : Tumorigen
 
                           Drug
 
                           Reproductive Effector
 
                           Human
 
 SYNONYMS/TRADE NAMES :
 
    * A 100
 
    * A 100 (Pharmaceutical)
 
    * B 75
 
    * Chinofer
 
    * Dextran iron complex
 
    * Dextrofer 75
 
    * Eisendextran
 
    * Fe-Dextran
 
    * Fenate
 
    * Ferdex 100
 
    * Ferric dextran
 
    * Ferridextran
 
    * Ferrodextran
 
    * Ferroglucin
 
    * Ferroglukin 75
 
    * Imposil
 
    * Iro-Jex
 
    * Iron dextran
 
    * Iron-dextran complex
 
    * Iron dextran injection
 
    * Iron hydrogenated dextran
 
    * Ironorm injection
 
    * Myofer 100
 
    * Polyfer
 
    * Prolongal
 
    * RCRA waste number U139
 
    * Ursoferran
 
  
 
                        *** HEALTH HAZARD DATA ***
 
  
 
                         ** ACUTE TOXICITY DATA **
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intraperitoneal
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 3 gm(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
 
    First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
 
    18,185,1971
 
  
 
 TYPE OF TEST            : LDLo - Lowest published lethal dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 1617 mg(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    ACVTA8 Acta Veterinaria (Belgrade).  (Jugoslovenska Knjiga, POB 36,
 
    YU-11001, Belgrade, Yugoslavia) V.1-    1951-  Volume(issue)/page/year:
 
    29,21,1979
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Oral
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 1 gm(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
 
    V.1-33, 1946-68.  For publisher information, see BJPCBM.
 
    Volume(issue)/page/year: 24,352,1965
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 460 mg(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
 
    (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
 
    Volume(issue)/page/year: 18,149,1961
 
  
 
 TYPE OF TEST            : LD - Lethal dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : >450 mg(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
 
    V.1-33, 1946-68.  For publisher information, see BJPCBM.
 
    Volume(issue)/page/year: 10,375,1955
 
  
 
 TYPE OF TEST            : LDLo - Lowest published lethal dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE/DURATION           : 500 mg(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
 
    V.1-33, 1946-68.  For publisher information, see BJPCBM.
 
    Volume(issue)/page/year: 10,375,1955
 
  
 
 TYPE OF TEST            : LD - Lethal dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE/DURATION           : >690 mg(Fe)/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
 
    V.1-33, 1946-68.  For publisher information, see BJPCBM.
 
    Volume(issue)/page/year: 10,375,1955
 
  
 
                  ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intraperitoneal
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 700 mg/kg/7D-I
 
 TOXIC EFFECTS :
 
    Cardiac - other changes
 
    liver - other changes
 
    Biochemical - Enzyme inhibition, induction, or change in blood or tissue
 
    levels - other oxidoreductases
 
 REFERENCE :
 
    JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
 
    1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
 
    Volume(issue)/page/year: 51,235,1997
 
  
 
                           ** TUMORIGENIC DATA **
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Human - woman
 
 DOSE/DURATION           : 20 mg/kg/3Y-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - neoplastic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
 
    Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
 
    2,277,1973
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 750 mg(Fe)/kg/4W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - Carcinogenic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    IJCNAW International Journal of Cancer.  (International Union Against
 
    Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
 
    Volume(issue)/page/year: 2,370,1967
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 1150 mg/kg/17W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - neoplastic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
 
    Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
 
    15,838,1961
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 2300 mg/kg/I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Blood - lymphoma, including Hodgkin's disease
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BECCAN Annual Report--Cancer Research Campaign.  (Cancer Research Campaign,
 
    2 Carlton House Terrace, London SW1Y 5AR, UK)  V.1-    1924-
 
    Volume(issue)/page/year: 40,30,1962
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 2 gm(Fe)/kg/9W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
 
    Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
 
    21,448,1967
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE/DURATION           : 28 gm/kg/27W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
 
    Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
 
    1,1593,1964
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - hamster
 
 DOSE/DURATION           : 40 gm/kg/10W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Liver - tumors
 
 REFERENCE :
 
    JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
 
    1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
 
    24,109,1960
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 1120 mg(Fe)/kg/28W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
 
    Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
 
    1,1800,1962
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 3760 mg(Fe)/kg/47W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - neoplastic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
 
    Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
 
    1,947,1959
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 104 gm/kg/26W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
 
    1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
 
    24,109,1960
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 1500 mg(Fe)/kg/8W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - Carcinogenic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    IJCNAW International Journal of Cancer.  (International Union Against
 
    Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
 
    Volume(issue)/page/year: 2,370,1967
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Human - woman
 
 DOSE/DURATION           : 52 mg(Fe)/kg/6W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - Carcinogenic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
 
    Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
 
    1,1411,1960
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 2400 mg(Fe)/kg/24W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - Carcinogenic by RTECS criteria
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
 
    Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
 
    18,801,1964
 
  
 
 TYPE OF TEST            : TD - Toxic dose (other than lowest)
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 104 gm/kg/13W-I
 
 TOXIC EFFECTS :
 
    Tumorigenic - equivocal tumorigenic agent by RTECS criteria
 
    Lungs, Thorax, or Respiration - bronchiogenic carcinoma
 
    Tumorigenic - tumors at site of application
 
 REFERENCE :
 
    JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
 
    1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
 
    24,109,1960
 
  
 
                           ** REPRODUCTIVE DATA **
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE                    : 2580 gm/kg
 
 SEX/DURATION            : female 17-20 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
 
    gain)
 
 REFERENCE :
 
    TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
 
    Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 5,147,1975
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE                    : 240 mg/kg
 
 SEX/DURATION            : female 6 week(s) pre-mating
 
 TOXIC EFFECTS :
 
    Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
 
    gain)
 
    Reproductive - Effects on Newborn - behavioral
 
 REFERENCE :
 
    BPNSBY Bulletin of the Psychonomic Society.  (Psychonomic Soc., 2904
 
    Guadalupe St., Austin, TX 78705) V.1-    1973-  Volume(issue)/page/year:
 
    10,49,1977
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intrauterine
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE                    : 52500 ug/kg
 
 SEX/DURATION            : female 1 day(s) pre-mating
 
 TOXIC EFFECTS :
 
    Reproductive - Maternal Effects - uterus, cervix, vagina
 
 REFERENCE :
 
    IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
 
    Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
 
    Volume(issue)/page/year: 19,1124,1981
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intramuscular
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE                    : 650 mg(Fe)/kg
 
 SEX/DURATION            : female 6-18 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
 
    e.g., stunted fetus)
 
 REFERENCE :
 
    SJHSBD Scandinavian Journal of Haematology, Supplementum.  (Munksgaard
 
    International Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  No.1- 1967- 
 
    Volume(issue)/page/year: 32,69,1977
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intrauterine
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE                    : 5250 ug/kg
 
 SEX/DURATION            : female 1 day(s) pre-mating
 
 TOXIC EFFECTS :
 
    Reproductive - Maternal Effects - uterus, cervix, vagina
 
    Reproductive - Fertility - female fertility index (e.g. # females pregnant
 
    per # sperm positive females; # females pregnant per # females mated)
 
 REFERENCE :
 
    IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
 
    Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
 
    Volume(issue)/page/year: 19,1124,1981
 
 
 
                               *** REVIEWS ***
 
  
 
    IARC Cancer Review:Animal Sufficient Evidence
 
    IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
 
    to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
 
    V.1-    1972-  Volume(issue)/page/year: 2,161,1973
 
 
 
    IARC Cancer Review:Human Inadequate Evidence
 
    IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
 
    to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
 
    V.1-    1972-  Volume(issue)/page/year: 2,161,1973
 
 
 
    IARC Cancer Review:Group 2B
 
    IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
 
    Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
 
    7,226,1987
 
 
 
    TOXICOLOGY REVIEW
 
    FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
 
    publisher information, see FCTOD7.  Volume(issue)/page/year: 9,105,1971
 
 
 
    TOXICOLOGY REVIEW
 
    BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
 
    Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
 
    1,683,1978
 
 
 
    TOXICOLOGY REVIEW
 
    PEXTAR Progress in Experimental Tumor Research.  (S. Karger AG, Postfach
 
    CH-4009 Basel, Switzerland) V.1-    1960-  Volume(issue)/page/year:
 
    12,102,1969
 
 
 
          *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
 
 
 
 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
 
    NOES - National Occupational Exposure Survey (1983)
 
      NOES Hazard Code - X4721
 
        No. of Facilities: 39 (estimated)
 
        No. of Industries: 1
 
        No. of Occupations: 2
 
        No. of Employees: 1157 (estimated)
 
        No. of Female Employees: 573 (estimated)
 
 
 
                           *** STATUS IN U.S. ***
 
  
 
    NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
 
 
 
  
 
                             *** END OF RECORD ***