Hydroxyethyl starch (cas 9005-27-0) MSDS

Download
Download
MSDS   :
  Starch, 2-hydroxyethyl ether
 
  
 CAS   
:
  9005-27-0 
 SYNONYMS   
:
  * Essex 1360
 
 * Essex gum 1360
 
 * Ethylex gum 2020
 
 * HAS
 
 * HES
 
 * Hespander
 
 * Hespander injection
 
 * Hydroxyathylstarke
 
 * O-(Hydroxyethyl)starch
 
 * 2-Hydroxyethyl starch
 
 * O-(2-Hydroxyethyl)starch
 
 * 2-Hydroxyethyl starch ether
 
 * Penford 260
 
 * Penford 280
 
 * Penford 290
 
 * Penford P 208
 
 * Plasmasteril
 
 * Starch hydroxyethyl ether
 
 * tapioca starch hydroxyethyl ether
 
 
 
  
Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers
[ Starch, 2-hydroxyethyl ether 9005-27-0 ]
  
                      *** CHEMICAL IDENTIFICATION ***
 
 
 
 RTECS NUMBER            : WI0410000
 
 CHEMICAL NAME           : Starch, 2-hydroxyethyl ether
 
 CAS REGISTRY NUMBER     : 9005-27-0
 
 LAST UPDATED            : 199806
 
 DATA ITEMS CITED        : 19
 
 COMPOUND DESCRIPTOR     : Drug
 
                           Reproductive Effector
 
 SYNONYMS/TRADE NAMES :
 
    * Essex 1360
 
    * Essex gum 1360
 
    * Ethylex gum 2020
 
    * HAS
 
    * HES
 
    * Hespander
 
    * Hespander injection
 
    * Hydroxyathylstarke
 
    * O-(Hydroxyethyl)starch
 
    * 2-Hydroxyethyl starch
 
    * O-(2-Hydroxyethyl)starch
 
    * 2-Hydroxyethyl starch ether
 
    * Penford 260
 
    * Penford 280
 
    * Penford 290
 
    * Penford P 208
 
    * Plasmasteril
 
    * Starch hydroxyethyl ether
 
    * Tapioca starch hydroxyethyl ether
 
  
 
                        *** HEALTH HAZARD DATA ***
 
  
 
                         ** ACUTE TOXICITY DATA **
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Oral
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : >50 gm/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
 
    Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
 
    Volume(issue)/page/year: 16,431,1974
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intraperitoneal
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : >300 gm/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
 
    Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
 
    Volume(issue)/page/year: 16,431,1974
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : >18 gm/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE/DURATION           : 8280 mg/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
 
    Japan)  Volume(issue)/page/year: -,1007,1995
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Oral
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : >12 gm/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intraperitoneal
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : >300 gm/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
 
    Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
 
    Volume(issue)/page/year: 16,431,1974
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Subcutaneous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : >18 gm/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE/DURATION           : 20300 mg/kg
 
 TOXIC EFFECTS :
 
    Behavioral - changes in motor activity (specific assay)
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1023,1972
 
  
 
 TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE/DURATION           : 8460 mg/kg
 
 TOXIC EFFECTS :
 
    Details of toxic effects not reported other than lethal dose value
 
 REFERENCE :
 
    NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
 
    Japan)  Volume(issue)/page/year: -,1007,1995
 
  
 
                  ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE/DURATION           : 1800 mL/kg/30D-C
 
 TOXIC EFFECTS :
 
    Cardiac - changes in heart weight
 
    liver - changes in liver weight
 
    Endocrine - changes in spleen weight
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1089,1972
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE/DURATION           : 1170 mL/kg/13W-I
 
 TOXIC EFFECTS :
 
    Liver - changes in liver weight
 
    Kidney, Ureter, Bladder - changes in bladder weight
 
    Related to Chronic Data - death
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1103,1972
 
  
 
                           ** REPRODUCTIVE DATA **
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intraperitoneal
 
 SPECIES OBSERVED        : Rodent - rat
 
 DOSE                    : 300 gm/kg
 
 SEX/DURATION            : female 16-21 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Fertility - abortion
 
 REFERENCE :
 
    ANATAE Anaesthesist.  (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin
 
    33, Fed. Rep. Ger.) V.1-    1952-  Volume(issue)/page/year: 24,244,1975
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE                    : 675 gm/kg
 
 SEX/DURATION            : female 8-16 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
 
    (e.g., placenta, umbilical cord)
 
    Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1119,1972
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - mouse
 
 DOSE                    : 420 gm/kg
 
 SEX/DURATION            : female 7-13 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
 
    gain)
 
 REFERENCE :
 
    OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
 
    Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 6,1119,1972
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE                    : 200 gm/kg
 
 SEX/DURATION            : female 8-17 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
 
    e.g., stunted fetus)
 
 REFERENCE :
 
    KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
 
    Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
 
    Volume(issue)/page/year: 6,121,1972
 
  
 
 TYPE OF TEST            : TDLo - Lowest published toxic dose
 
 ROUTE OF EXPOSURE       : Intravenous
 
 SPECIES OBSERVED        : Rodent - rabbit
 
 DOSE                    : 100 gm/kg
 
 SEX/DURATION            : female 8-17 day(s) after conception
 
 TOXIC EFFECTS :
 
    Reproductive - Specific Developmental Abnormalities - musculoskeletal system
 
 REFERENCE :
 
    KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
 
    Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
 
    Volume(issue)/page/year: 6,121,1972
 
 
 
          *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
 
 
 
 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
 
    NOHS - National Occupational Hazard Survey (1974)
 
      NOHS Hazard Code - M2691
 
        No. of Facilities: 131 (estimated)
 
        No. of Industries: 5
 
        No. of Occupations: 11
 
        No. of Employees: 3716 (estimated)
 
    
 
    NOES - National Occupational Exposure Survey (1983)
 
      NOES Hazard Code - X7988
 
        No. of Facilities: 582 (estimated)
 
        No. of Industries: 13
 
        No. of Occupations: 26
 
        No. of Employees: 30655 (estimated)
 
        No. of Female Employees: 9661 (estimated)
 
 
 
                           *** STATUS IN U.S. ***
 
  
 
    EPA TSCA Section 8(b) CHEMICAL INVENTORY
 
 
 
  
 
                             *** END OF RECORD ***