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sodium hydrogen phosphate(CAS No. 7558-79-4)

sodium hydrogen phosphate Na2HPO4 (cas 7558-79-4) Molecular Structure

7558-79-4 Structure

Identification and Related Records

【Name】
sodium hydrogen phosphate
【CAS Registry number】
7558-79-4
【Synonyms】
Disodium hydrogen phosphate
Sodium phosphate,dibasic
Disodium hydrogen phosphate,edible
disodium orthophosphate
di-sodium hydrogen orthophosphate
di-Sodium Hydrogenphosphate
Disodium Monohydrogen Orthophoshate
disodium monohydrogen phosphate
Disodium Monophosphate
disodium phosphoric acid
Phosphoric acid, disodium salt
Sodium acid phosphate
dibasic sodium phosphate
Sodium monohydrogen phosphate
sodium monohydrogen phosphate (2:1:1)
Sodium Phosphate Dibasic
SODIUM PHOSPHATE REAGENT GRADE DIBASIC
soda phosphate
Disodium Phosphate Dihydrate
DSP
Disodium Phosphate
Disodium Phosphate
Di-Sodium Phosphate
Sodium Phosphate, Dibasic Anhydrous
【EINECS(EC#)】
231-448-7
【Molecular Formula】
Na2HPO4 (Products with the same molecular formula)
【Molecular Weight】
141.96
【Inchi】
InChI=1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2
【InChIKey】
BNIILDVGGAEEIG-UHFFFAOYSA-L
【Canonical SMILES】
OP(=O)([O-])[O-].[Na+].[Na+]
【MOL File】
7558-79-4.mol

Chemical and Physical Properties

【Appearance】
white granular powder
【Density】
1.064 g/mL at 20 °C
【Melting Point】
243-245 °C
【Boiling Point】
158 °C at 760 mmHg
【Water】
>=10 g/100 mL at 20℃
【Solubilities】
>=10 g/100 mL at 20 oC
【Color/Form】
Colorless, translucent crystals or white powder.
White, hygroscopic powder
【Stability】
Stable. Incompatible with strong acids. Hygroscopic.
【HS Code】
28352200
【Storage temp】
Store at RT.
【Computed Properties】
Molecular Weight:141.958841 [g/mol]
Molecular Formula:HNa2O4P
H-Bond Donor:1
H-Bond Acceptor:4
Rotatable Bond Count:0
Exact Mass:141.940784
MonoIsotopic Mass:141.940784
Topological Polar Surface Area:83.4
Heavy Atom Count:7
Formal Charge:0
Complexity:46.5
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:3

Safety and Handling

【Hazard Codes】
Xi:刺激性物质;
【Risk Statements】
R36/37/38
【Safety Statements 】
S24/25;S36
【HazardClass】
9
【Safety】

Safety Information of Disodium hydrogenorthophosphate (CAS NO.7558-79-4):
Hazard Codes: XiIrritant
Risk Statements: 36/37/38??
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3

【Sensitive】
Hygroscopic
【Skin, Eye, and Respiratory Irritations】
Dust: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. Solid: Irritating to skin and eyes.
A skin and eye irritant.
【Cleanup Methods】
/SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental Consideration: Land spill Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.
Environmental Consideration: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.
【Fire Fighting Procedures】
If material is on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)
【Fire Potential】
Nonflammable
【Formulations/Preparations】
Sodium Phosphates Injection, USP, 3 mM P/mL (millimoles/mL)... Each mL contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). ... It contains no bacteriostat, antimicrobial agent or added buffer.
Sodium Phosphate preparations: (AHFS, 2009) Sodium Phosphate preparations: (AHFS, 2009) Route Dosage Form Strength Brand or Generic Name (Manufacturer) Oral Tablet Dibasic Sodium Phosphate (anhydrous) 0.398 g with Monobasic Sodium Phosphate (monohydrate) 1.102 g OsmoPrep (Salix) Oral Tablet Dibasic Sodium Phosphate (anhydrous) 0.398 g with Monobasic Sodium Phosphate (monohydrate) 1.102 g Visicol (Salix) Rectal Solution Dibasic Sodium Phosphate 60 mg/mL with Monobasic Sodium Phosphate 160 mg/mL Fleet Enema (Fleet) Rectal Solution Dibasic Sodium Phosphate 60 mg/mL with Monobasic Sodium Phosphate 160 mg/mL Fleet Pediatric Enema (Fleet)
Visicol (sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP)... Each tablet contains 1.102 grams of sodium phosphate monobasic monohydrate, USP and 0.398 grams of sodium phosphate dibasic anhydrous, USP for a total of 1.5 grams of sodium phosphate per tablet. Inert ingredients include microcrystalline cellulose (MCC), NF; magnesium stearate, NF; and colloidal silicon dioxide, NF. Visicol is gluten-free.
Sodium phosphate and sodium biphosphate enema USP ... dosage forms-- enema USP: 6% sodium phosphate and 16% sodium biphosphate; sodium phosphate and sodium biphosphate oral solution USP ... dosage forms-- solution USP: 18% sodium phosphate and 48% sodium biphosphate.
Sorensen's phosphate, Sorensen's sodium phosphate. /Disodium phosphate dihydrate/
Fleet's enema: solution (sodium phosphate 6 g and sodium biphosphate 16 g). Fleet's phospho-soda: (sodium phosphate 18 g and sodium biphosphate 48 g).
... An oral soln (FLEET PHOSPHO-SODA) contains 1.8 g of dibasic sodium phosphate and 4.8 g of monobasic sodium phosphate in 10 mL ... /Saline laxatives/
Grade: Commercial, NF /National formulary grade of chemical/ (sodium phosphate, dibasic anhydrous and heptahydrate), FCC /Food chemicals Codex/ (sodium phosphate, dibasic anhydrous or dihydrate)
Available as anhydrous or dihydric salts.
【Exposure Standards and Regulations】
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: sodium phosphate is included in anticaries drug products.
【Other Preventative Measures】
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
If material is not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.
Personnel Protection: Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
【Protective Equipment and Clothing】
Dust: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. Solid: Irritating to skin and eyes.
A skin and eye irritant.
【Specification】

?Disodium hydrogenorthophosphate , its CAS NO. is 7558-79-4, the synonyms are Dibasic sodium phosphate ; Disodium acid orthophosphate ; Disodium acid phosphate ; Disodium hydrogen phosphate ; Disodium hydrogen phosphate, anhydrous ; Disodium hydrophosphate ; Disodium monohydrogen phosphate ; Disodium orthophosphate ; Disodium phosphate ; Disodium phosphate, anhydrous ; Disodium phosphoric acid ; Exsiccated sodium phosphate ; Natriumphosphat? ; Phosphate of soda ; Phosphoric acid, disodium salt ; Soda phosphate ; Sodium acid phosphate, anhydrous ; Sodium hydrogen phosphate ; Sodium monohydrogen phosphate ; Sodium orthophosphate, secondary ; Sodium phosphate? ; Sodium phosphate, dibasic ; Sodium phosphate, exsiccated ; secondary Sodium phosphate .

【Report】

Reported in EPA TSCA Inventory.

【Disposal Methods】
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

By precipitating calcium carbonate from a solution of dicalcium phosphate with soda ash.
By treating phosphoric acid with a slight excess of soda ash, boiling the solution to drive off carbon dioxide and cooling to permit the dodecahydrate to crystallize.
... The disodium /phosphate/ is produced from phosphoric acid and sodium carbonate.
Sodium monophosphates are usually produced by neutralization of phosphoric acid with soda ash or caustic soda. The latter is predominantly used in Germany, while in the United States, the less expensive soda ash prevails. The basicity of sodium carbonate is insufficient for the formation of trisodium phosphate, so that caustic soda must be used in this step. The phosphates crystallize from the solutions as hydrates and are separated by centrifugation. Anhydrous salts are obtained by dehydration in rotary dryers or directly from the solutions by spray drying or in rotary kilns. Both thermal phosphoric acid and the cheaper wet phosphoric acid are used as starting materials. The very pure thermal phosphoric acid is generally used in the production of food-grade phosphates. /Sodium monophosphates/
Both thermal and purified wet phosphoric acid are used in production. In a process developed in the 1980s, acidic phosphate solution (CaHPO4 in the presence of H3PO4) is treated with NaHSO4, whereby purification occurs through precipitation of gypsum. Neutralization with NaOH is carried out in a second stage. Salts are obtained from the neutralized solutions by evaporation, crystallization, and centrifugation. The desired hydrate is obtained by appropriate temperature control. The anhydrous product is also produced by dehydration of the solution in a spray drying tower. Careful temperature control is required to avoid formation of tetrasodium diphosphate.
U.S. Exports

(1984) 1.74X10+10 G /SODIUM PHOSPHATES, NSPF/
U.S. Production

(1972) 1.89X10+10 GRAMS
(1975) 2.18X10+10 GRAMS
(1984) 2.87X10+10 G
(1990) >10 thousand-500 thousand pounds
(1994) >10 thousand-500 thousand pounds
(2002) >10 thousand-500 thousand pounds
Production volumes for non-confidential chemicals reported under the Inventory Update Rule. Year Production Range (pounds) 1986 No Reports 1990 10 thousand - 500 thousand 1994 10 thousand - 500 thousand 1998 No Reports 2002 10 thousand - 500 thousand
Consumption Patterns

57-67% as a food additive, mainly as an emulsifier in processed cheese; 24-29% as an industrial and institutional detergent builder and in water treatment; 10-14% in misc applications (pharmaceuticals, cattle feed supplement, in various textile processes and for export) (1973)
【Usage】

Ph adjustment, fungicide, herbicide, microbiocide.

Biomedical Effects and Toxicity

【Pharmacological Action】
- Agents that are used to stimulate evacuation of the bowels.
【Therapeutic Uses】
Cathartics
Sodium Phosphates Injection, USP, ... is indicated as a source of phosphorus, for addition to large volume intravenous fluids, to prevent or correct hypophosphatemia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific parenteral fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. /Included in US product label/
Visicol tablets are indicated for cleansing of the colon as a preparation for colonoscopy in adults 18 years of age or older. /Included in US product label/
Although sodium and/or potassium phosphates have been used in the treatment of hypercalcemia, USP medical advisory panels do not recommend this use since these medications have been replaced by safer and more effective agents. /Phosphates/
To determine whether phosphate supplementation, started soon after birth in adequate quantity, would prevent rickets in very low birth weight infants with prenatal deficiency of phosphate, 40 neonates were given an initial dose of 50 mg/day of phosphate administered as a mixture of 189 g of sodium phosphate dibasic (disodium hydrogen phosphate) and 82 g of sodium phosphate monobasic (sodium dihydrogen phosphate) made up to 2 liters with single strength chloroform water or placebo (single strength chloroform water). Supplementation was increased to 37.5 mg every 12 hr if the plasma phosphate concentration remained less than 1.5 mmol/L after one wk. Results showed that no infant receiving phosphate supplements had radiological evidence of rickets whereas bone changes were apparent in 42% of the control group. It was concluded that prenatal deficiency of phosphate, due to placental insufficiency, can be corrected by phosphate supplementation, thereby preventing rickets of prematurity. [Holland PC et al; Lancet 335: 697-701 (1990)]
【Biomedical Effects and Toxicity】
... Phosphates (dibasic and monobasic sodium phosphate) are slowly and incompletely absorbed. /Dibasic and Monobasic Sodium phosphate/
Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses. /Phosphorus/
Elimination: Renal (90%) and fecal (10%). /Phosphates/
Ingested phosphates are absorbed from the gastrointestinal tract. However, the presence of large amounts of calcium or aluminum may lead to formation of insoluble phosphate and reduce the net absorption. Vitamin D stimulates phosphate absorption. /Phosphates/
Transport of phosphate from the gut lumen is an active, energy-dependent process ... In adults, about two-thirds of the ingested phosphate is absorbed and is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/
More than 90% of plasma phosphate is filterable, of which 80% is actively reabsorbed. Most reabsorption occurs in the initial segment of the proximal tubule, with a lesser component in the pars recta ... Phosphate excreted in the urine represents the difference between the amt filtered and that reabsorbed. Expansion of plasma volume increases urinary phosphate excretion. Parathyroid hormone (PTH) increases urinary phosphate excretion by blocking reabsorption. Vitamin D and its metabolites directly stimulate proximal tubular phosphate reabsorption. /Phosphates/
Artery blood pressure is a major determinant of Na+ excretion ... The renin-angiotensin system plays a major role in maintaining a constant set point for long-term levels of arterial blood pressure despite extreme changes in dietary Na+ intake ... When dietary Na+ intake is low, renin release is stimulated, and angiotensin II acts on the kidney to shift the renal pressure-natriuresis curve to the right ... When dietary Na+ is high, renin release is inhibited, and the withdrawal of angiotensin II causes the renal pressure-natriuresis curve to shift to the left. Consequently, the intersection of salt intake with the renal pressure-natriuresis curve remains near the same set point ... /Na+ excretion/
Intravenously infused phosphorus not taken up by the tissues is excreted almost entirely in the urine. Plasma phosphorus is believed to be filterable by the renal glomeruli, and the major portion of filtered phosphorus (greater than 80%) is actively reabsorbed by the tubules. Many modifying influences tend to alter the amount excreted in the urine.
An open-label pharmacokinetic study of Visicol in healthy volunteers was performed to determine the concentration-time profile of serum inorganic phosphorus levels after Visicol administration. All subjects received a total of 60 grams of sodium phosphate with a total liquid volume of 3.6 quarts. Subjects received a 30 gram dose (20 tablets given as 3 tablets every 15 minutes with 8 ounces of clear liquids) beginning at 6 PM and then received a second 30 gram dose (20 tablets given as 3 tablets every 15 minutes with 8 ounces of clear liquids) the following morning beginning at 6 AM. Twenty-three healthy subjects (mean age 57 years old; 57% male and 43% female; and 65% Hispanic, 30% Caucasian, and 4% African-American) participated in this pharmacokinetic study. The serum phosphorus level rose from a mean (+/- standard deviation) baseline of 4.0 (+/- 0.7) mg/dL to 7.7 (+/- 1.6 mg/dL), at a median of 3 hours after the administration of the first 30 gram dose of Visicol tablets The serum phosphorus level rose to a mean of 8.4 (+/- 1.9) mg/dL, at a median of 4 hours after the administration of the second 30 gram dose of Visicol tablets. The serum phosphorus level remained above baseline for a median of 24 hours after the administration of the initial dose of Visicol tablets (range 16 to 48 hours).

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