Related Searches: Hydrochloric acid, acid hydrochloric, hydrochloric price acid, hydrochloric, acid ester, View all

Hydrochloric acid(CAS No. 7647-01-0)

Hydrochloric acid HCl (cas 7647-01-0) Molecular Structure

7647-01-0 Structure

Identification and Related Records

【Name】
Hydrochloric acid
【CAS Registry number】
7647-01-0
【Synonyms】
Chlorohydric acid
Hydrogen chloride
Hydrogen chloride (acid)
HYDROGEN CHLORIDE GAS ONLY
Muriatic acid
Hydrochloric acid,refined
Hydrochloric acid,medicinal
chlorhydric acid
HCL
【EINECS(EC#)】
231-595-7
【Molecular Formula】
HCl (Products with the same molecular formula)
【Molecular Weight】
36.46
【Inchi】
InChI=1/ClH/h1H
【InChIKey】
VEXZGXHMUGYJMC-UHFFFAOYSA-N
【Canonical SMILES】
Cl
【MOL File】
7647-01-0.mol

Chemical and Physical Properties

【Appearance】
A colorless gas with a sharp, pungent odor.
【Density】
1.18
【Melting Point】
-35℃
【Boiling Point】
57℃
【Vapour】
613 psi ( 21.1 °C)
【Flash Point】
11℃
【Water】
miscible
【Solubilities】
Miscible
【Stability】
Stable. Incompatible with alkalies, most metals. Avoid contact with water.
【Storage temp】
2-8°C
【Spectral properties】
Index of refraction: 1.254 (liquid at 283.16 K); 1.0004456 (gas at 273.16 K)
【Computed Properties】
Molecular Weight:36.46094 [g/mol]
Molecular Formula:ClH
XLogP3-AA:0.8
H-Bond Donor:1
H-Bond Acceptor:0
Rotatable Bond Count:0
Exact Mass:35.976678
MonoIsotopic Mass:35.976678
Topological Polar Surface Area:0
Heavy Atom Count:1
Formal Charge:0
Complexity:0
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Anion Count:1
Effective Rotor Count:0
Conformer Sampling RMSD:0.4
CID Conformer Count:1

Safety and Handling

【Hazard Codes】
C:Corrosive;
【Risk Statements】
R34;R37
【Safety Statements 】
S26;S45
【HazardClass】
3
【Safety】

Hazard Codes of Hydrogen chloride (CAS NO.7647-01-0):?ToxicT,?CorrosiveC,?FlammableF,?IrritantXi,?HighlyF+
Risk Statements: 36/37/38-34-35-23-20-11-67-66-19-12-10-40-20/22
R36/37/38: Irritating to eyes, respiratory system and skin.
R34: Causes burns.
R35: Causes severe burns.
R23: Toxic by inhalation.
R20: Harmful by inhalation.
R11: Highly flammable.
R67: Vapours may cause drowsiness and dizziness.
R19: May form explosive peroxides.
R12: Extremely flammable.
R10: Flammable.
R40: Limited evidence of a carcinogenic effect.
R20/22: Harmful by inhalation and if swallowed.
Safety Statements: 26-45-36/37/39-9-33-29-16-46
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S9: Keep container in a well-ventilated place.
S33: Take precautionary measures against static discharges.
S29: Do not empty into drains.
S16: Keep away from sources of ignition.
S46: If swallowed, seek medical advice immediately and show this container or label.
RIDADR: UN 2924 3/PG 2
WGK Germany: 2
RTECS: MW4025000
F: 3
HazardClass: 3
PackingGroup: I
A highly corrosive irritant to the eyes, skin, and mucous membranes. Mildly toxic by inhalation. Explosive reaction with alcohols + hydrogen cyanide, potassium permanganate, sodium (with aqueous HCl), tetraselenium tetranitride. Ignition on contact with aluminum-titanium alloys (with HCl vapor), fluorine, hexalithium disilicide, metal acetylides or carbides (e.g., cesium acetylide, rubidium acetylide). Violent reaction with 1,1-difluoroethylene. Vigorous reaction with aluminum, chlorine + dinitroanilines (evolves gas). Potentially dangerous reaction with sulfuric acid releases HCl gas. Adsorption of the acid onto silicon dioxide is exothermic. See also HYDROGEN CHLORIDE (aerosol) and HYDROCHLORIC ACID.

【PackingGroup 】
I
【Sensitive】
Air & Light Sensitive
【Skin, Eye, and Respiratory Irritations】
An aqueous solution (4%) of hydrogen chloride was slightly irritating, and a 10% solution was determined to be ?Irritating to skin' ... in human volunteer experiments.
【Cleanup Methods】
If hydrogen chloride gas is leaked ... 1. Ventilate area of leak to disperse gas. 2. Stop flow of gas. If source of leak is a cylinder and the leak cannot be stopped in place, remove the leaking cylinder to a safe place in the open air, and repair the leak or allow the cylinder to empty. If soln of hydrogen chloride is spilled ... 1. Collect or confine spilled material in the most convenient and safe manner. 2. If possible, reclaim the spilled material. If this is not possible; 3. Dilute and/or neutralize and dispose of in a secured sanitary landfill. /Hydrogen chloride gas/
Spills in Water: Sodium bicarbonate is recommended as an in situ neutralizing agent. /Hydrochloric acid/
During scrubbing (an air pollution control method), water is used for removing hydrochloric acid.
Environmental considerations -- land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethan or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3). Water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3) or sodium bicarbonate (NaHCO3). Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment. /Hydrochloric acid; Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
The following absorbent materials have been tested and recommended for vapor suppression and/or containment of 26% and 35% hydrochloric acid solutions: a mixture of (75%) anionic polyacrylamide (R1779) and (25%) nonionic polyacrylamide (Versicol W25), individually use the anionic polyacrylamide or nonionic polyacrylamide, and Cellosize WP3H (hydroxyethyl cellulose). /Hydrochloric acid/
Approach release from upwind. Stop or control the leak, if this can be done without undue risk. Use water fog or spray to knock down and absorb vapors. Releases may require isolation or evacuation. Control runoff and isolate discharged material for proper disposal. /Hydrogen chloride, anhydrous; hydrogen chloride, refrigerated liquid/
【Transport】
UN 1789
【Fire Fighting Procedures】
Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire. /Hydrogen chloride, anhydrous; hydrogen chloride, refrigerated liquid/
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty). Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Hydrochloric acid/
Noncombustible, but contact with metals may produce highly flammable hydrogen gas.
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty). Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use water spray to knock-down vapors. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
【Formulations/Preparations】
GRADES: UNITED STATES PHARMACOPEIA (USP) (35-38%); NATIONAL FORMULARY (NF) DILUTED (10%); TECHNICAL (USUALLY 18, 20, 22, 23 DEG BAUME, CORRESPONDING TO APPROX 28, 31, 35, 37% HYDROGEN CHLORIDE). /HYDROCHLORIC ACID/
4-D Bowl Sanitizer; solution-ready to use, 27.64% hydrogen chloride, 0.1500% benzyl-4-chlorophenol, 0.200% diisobutyl phenoxyethoxyethyl dimethyl benzyl ammonium. /Hydrochloric acid/
Varley's Ocean Blue Scented Toilet Bowl Cleaner; solution-ready to to use, 25.82% hydrogen chloride, 1.0% benzyl-4-chlorophenol, 0.2% diisobutyl phenoxyethoxyethyl dimethyl benzyl ammonium. /Hydrochloric acid/
Varley Poly-Pak Bowl Creme; soluble concentrate, 27.64% hydrogen chloride, 0.15% benzyl-4-chlorophenol, 0.2% diisobutyl phenoxyethoxyethyl dimethyl benzyl ammonium. /Hydrochloric acid/
Bowl Cleaner; soluble concentrate, 26.0% hydrogen chloride, 2.5% orthodichlorobenzene. /Hydrochloric acid/
Emulsion Bowl Cleaner; emulsifiable concentrate, 26.1500% hydrogen chloride, 2.94% orthodichlorobenzene. /Hydrochloric acid/
Quest Bowl Cleaner Super Concentrated; solution-ready to use, 0.46% oxalic acid, 32.2% hydrogen chloride, 0.12% alkyl dimethyl benzyl ammonium chloride, 0.06% alkyl dimethyl ethylbenzyl ammonium chloride. /Hydrochloric acid/
New South Safti-Sol Brand Concentrated Bowl Cleanse with Magic Actio; soluble concentrate, 29.45% hydrogen chloride, 0.35% aeptadeeyl hydroxyethyl imidazoline, 0.25% alkyl dimethyl benzyl ammonium chloride, 0.25% alkyl dimethyl rthylbenzyl ammonium chloride. /Hydrochloric acid/
Perclean Bowl and Urinal Cleaner; solution-ready to use, 25.18% hydrogen chloride, 1.2% alkyl dimethyl benzyl ammonium chloride. /Hydrochloric acid/
White Emulsion Bowl Cleaner; solution-ready to use, 27.64% hydrogen chloride, 0.15% benzyl-4-chlorophenol, 0.2000% diisobutyl phenoxyethoxyethyl dimethyl benzyl ammonium. /Hydrochloric acid/
Aygeia Creme Magic Bowl Cleaner; emulsifiable concentrate, 59.15% hydrogen chloride, 10.2% ortho-dichlorobenzene. /Hydrochloric acid/
The commercial "concentrated" or fuming acid contains 38% hydrochloric acid.
Available commercially as a 31% w/w (22 deg Baume, d: 1.16 kg/l) or 35% w/w (22 deg Baume, d: 1.18 kg/l) solution in water. /Hydrochloric acid/
Emulso Germicidal Bowl Cleaner: Active Ingredient 24.70% hydrogen chloride, 0.30% alkyl* dimethyl benzyl ammonium chloride *(58% C14, 28% C16, 14% C12). /Hydrochloric acid/
Sno Bol Toilet Bowl Cleaner: Active Ingredient 14.50% hydrogen chloride, 0.04% alkyl* dimethyl benzyl ammonium chloride *(50% C14, 40% C12, 10% C16), 0.02% didecyl dimethyl ammonium chloride, 0.03% octyl decyl dimethyl ammonium chloride, 0.01% dioctyl dimethyl ammonium chloride. /Hydrochloric acid/
Adorn Toilet Bowl Cleaner: Active Ingredient 9.50% hydrogen chloride, 0.05% alkyl* dimethyl benzyl ammonium chloride *(60% C14, 30% C16, 5% C18, 5% C12), 0.05% alkyl* dimethyl ethylbenzyl ammonium chloride *(68% C12, 32% C14). /Hydrochloric acid/
Beauty Liquid Disinfecting Toilet Bowl Cleaner: Active Ingredient 9.55% hydrogen chloride, 0.10% alkyl* dimethyl benzyl ammonium chloride *(60% C14, 30% C16, 5% C18, 5% C12), 0.10% alkyl* dimethyl ethylbenzyl ammonium chloride *(68% C12, 32% C14). /Hydrochloric acid/
Xinix: Active Ingredient 9.0000 hydrogen chloride. /Hydrochloric acid/
Vani-Sol Bowl Cleaner: Active Ingredient 23.00% hydrogen chloride. /Hydrochloric acid/
Vani-Sol Per Diem: Active Ingredient 8.00% hydrogen chloride, 1.00% alkyl* dimethyl benzyl ammonium chloride *(67% C12, 25% C14, 7% C16, 1% C8, C10, and C18). /Hydrochloric acid/
Lysol Liquid Disinfectant Toilet Bowl Cleaner: Active Ingredient 9.50% hydrogen chloride, 0.75% alkyl* dimethyl benzyl ammonium chloride *(67% C12, 25% C14, 7% C1 6, 1% C8, C10, and C18). /Hydrochloric acid/
Zep-O-San: Active Ingredient 23.00% hydrogen chloride. /Hydrochloric acid/
Zep Veto Germicidal Bowl Cleaner: Active Ingredient 5.50% hydrogen chloride, 22.50% phosphoric acid. /Hydrochloric acid/
TBC: Active Ingredient 9.50% hydrogen chloride, 0.06% methyldodecylbenzyl trimethyl ammonium chloride 80% and methyldodecylxylylene bis(trimethyl ammonium chloride) 20%. /Hydrochloric acid/
Oxford D'Germ Disinfectant-Toilet-Urinal Cleaner: Active Ingredient 4.50% hydrogen chloride, 22.50% phosphoric acid, 15.67% dodecylbenzenesulfonic acid. /Hydrochloric acid/
【DOT Emergency Guidelines】
If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/ Table of Initial Isolation and Protective Action Distances for Hydrogen chloride, anhydrous Small Spills (from a small package or small leak from a large package) -------------------- First ISOLATE in all Directions 30 meters (100 feet) Then PROTECT persons Downwind during DAY: 0.1 kilometers (0.1 miles) Then PROTECT persons Downwind during NIGHT: 0.4 kilometers (0.3 miles) ==================== Large Spills (from a large package or from many small packages) -------------------- First ISOLATE in all Directions 360 meters (1200 feet) Then PROTECT persons Downwind during DAY: 3.6 kilometers (2.2 miles) Then PROTECT persons Downwind during NIGHT: 10.4 kilometers (6.5 miles)
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or contaminated with water. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Fire: Note: Most foams will react with the material and release corrosive/toxic gases. Small fires: CO2 ... , dry chemical, dry sand, alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Use water spray or fog; do not use straight streams. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. DO NOT GET WATER INSIDE CONTAINERS. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. Small spills: Cover with DRY earth, DRY sand, or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 157: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE/WATER -SENSITIVE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Hydrochloric acid; Hydrochloric acid, solution/
/GUIDE 125: GASES - CORROSIVE/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Vapors are extremely irritating and corrosive. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ Fire or Explosion: Some may burn, but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. Ventilate closed spaces before entering. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ Fire: Small fires: Dry chemical or CO2. Large fires: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Do not get water inside containers. Damaged cylinders should be handled only by specialists. Fire involving tanks: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ Spill or Leak: Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Isolate area until gas has dispersed. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
/GUIDE 125: GASES - CORROSIVE/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with liquefied gas, thaw frosted parts with lukewarm water. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. ... Keep victim warm and quiet. Keep victim under observation. Effects of contact or inhalation may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
【Exposure Standards and Regulations】
Hydrochloric acid used as a buffer and neutralizing agent in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
This substance is generally recognized as safe when used as a buffer and neutralizing agent in accordance with good manufacturing practice.
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: hydrochloric acid is included in digestive aid drug products.
【Reactivities and Incompatibilities】
The aqueous solution is a strong acid. Corrosive fumes emitted on contact with air. Reacts violently with bases, oxidizers forming toxic chlorine gas. Reacts, often violently, with acetic anhydride, active metals, aliphatic amines, alkanolamines, alkylene oxides, aromatic amines, amides, 2-aminoethanol, ammonia, ammonium hydroxide, calcium phosphide, chlorosulfonic acid, ethylene diamine, ethyleneimine, epichlorohydrin, isocyanates, metal acetylides, oleum, organic anhydrides, perchloric acid, 3-propiolactone, uranium phosphide, sulfuric acid, vinyl acetate, vinylidene fluoride. Highly corrosive to most metals, forming flammable hydrogen gas. Attacks some plastics, rubber, and coatings.
Hydrochloric acid and hydrogen chloride react violently with many metals, with the generation of highly flammable hydrogen gas, which may explode. Reaction with oxidizers such as permanganates, chlorates, chlorites, and hypochlorites may produce chlorine or bromine gas.
Anhydrous hydrogen chloride is rapidly absorbed in water to form corrosive hydrochloric acid. Aqueous hydrochloric acid solutions are quite reactive. Reacts vigorously with alkalies and with many organic materials. Strong oxidizing materials cause release of chlorine. /Hydrogen chloride, anhydrous; hydrogen chloride, refrigerated liquid/
Cesium acetylene carbide burns in hydrogen chloride gas.
Lithium silicide in contact with hydrogen chloride becomes incandescent. When dilute hydrochloric acid is used, gas spontaneously flammable in air is evolved. Magnesium boride ... treated with concn hydrochloric acid produces spontaneously flammable gas.
Rubidium acetylene carbide burns with slightly warm hydrochloric acid or with molten sulfur. Rubidium carbide ignites in contact with hydrochloric acid unless acid is dilute.
Uranium phosphide reacts with hydrochloric acid to release spontaneously flammable phosphine.
Calcium carbide reacts with hydrogen chloride gas with incandescence.
Calcium phosphide and hydrochloric acid undergo very energetic reaction.
Absorption of gaseous hydrogen chloride on mercuric sulfate becomes violent @ 125 deg C.
Reaction of silver perchlorate with carbon tetrachloride in presence of small amt of hydrochloric acid produces trichloromethyl perchlorate, which detonates @ 40 deg C.
Aqueous hydrochloric acid solutions react with most metals, forming flammable hydrogen gas. /Hydrogen chloride, anhydrous; hydrogen chloride, refrigerated liquid/
Hydroxides, amines, alkalis, copper, brass, zinc [Note: Hydrochloric acid is highly corrosive to most metals].
With sulfuric acid: Accidental addition of 6,500 liters of concn hydrochloric acid to a bulk sulfuric acid storage tank released sufficient hydrogen chloride by dehydration to cause the tank to explode violently. Complete dehydration of hydrochloric acid solution releases some 250 volumes of gas.
Cesium carbide ignites in contact with hydrochloric acid unless acid is dilute.
Sodium reacts very vigorously with gaseous hydrogen chloride.
Magnesium boride, when treated with concentrated hydrochloric acid, produces a spontaneously flammable gas.
The hydronium compound /with perchloric acid/ decomposes spontaneously with violence. /Hydrochloric acid/
【Other Preventative Measures】
Wear goggles or face shield. Wear protective clothing (long-sleeve shirt and long pants, socks with shoes and chemical resistant gloves such as water proof gloves. Wash hands before eating, drinking, chewing gum using tobacco or using the toilet. Remove contaminated clothing and wash clothing before reuse. /Emulso Germicidal Bowl Cleaner Disinfectant/
FIRST AID: Have the product container or label with you when calling a poison control center or doctor or going for treatment. IF SWALLOWED: CaIl a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told by a poison control center or doctor. Do not give anything by mouth to an unconscious person. IF IN EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present after the first 5 minutes, then continue rinsing. Call a poison controi center or doctor for treatment advice. IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice. IF INHALED: Move person to fresh air. If person is not breathing, call 911 or an ambulance and then give artificial respiration. .. Call a poison control center or doctor for further treatment... /Emulso Germicidal Bowl Cleaner Disinfectant/
Hydrochloric acid should be manufactured in closed systems; particular attention should be paid to the detection of leaks ... When handling ... (loading, unloading, and decanting), measures should be taken to avoid splashes or the inhalation of vapors ... Difficult operations should be carried out in fume cupboards or under exhaust ventilation and an abundant supply of water should always be available ... Workers should never enter tanks or other vessels that have contained hydrochloric acid until ... they have been cleaned. /Hydrochloric acid/
Aqueous scrubbers are used to control hydrogen chloride emissions from vent stacks and other sources. /Hydrogen chloride/
If material not involved in fire: Keep material out of water sources, and sewers. Build dikes to contain flow as necessary. Use water spray to knock down vapors. Neutralize spilled material with crushed limestone, soda ash, or lime. /Hydrochloric acid/
If material not involved in fire: Keep material out of water sources and sewers. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. Neutralize spilled material with crushed limestone, soda ash, or lime. Do not use water on material itself. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
Personal Protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Hydrochloric acid; Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. /Hydrogen chloride/
SRP: When working with strong solutions of acids or bases or other caustic or corrosive materials, always wear a full face mask. When working with caustic or corrosive gases or vapors, a full face mask will not protect the eyes or prevent inhaling the material. A full face respirator is required. /Hydrochloric acid/
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
The worker should immediately wash the skin when it becomes contaminated. /Hydrochloric acid solution/
Work clothing that becomes wet or significantly contaminated should be removed or replaced. /Hydrochloric acid solution/
Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions. /Hydrogen chloride, anhydrous/
Evacuation: If fire is prolonged and material is confined in the container? consider evacuation of one (1) mile radius. If fire becomes uncontrollable or container is exposed to direct flame?consider evacuation of one (1) mile radius. /Hydrogen chloride, refrigeratd liquid/
Emergency responders ... should be trained and appropriately attired before entering the Hot Zone. If the proper equipment is not available, or if rescuers have not been trained in its use, assistance should be obtained from a local or regional HAZMAT team or other properly equipped response organization.
【Protective Equipment and Clothing】
Workers should wear acid resistant protective clothing, incl hoods, eye & face protection, acid resistant hand & arm protection, & foot & leg protection ... Workers should wear resp protective equipment of self contained or canister type depending on concn. /Hydrochloric acid/
For entry into a situation where the spilled material and its characteristics are unknown ... a totally encapsulated chemical suit should be worn. /Hydrochloric acid/
SRP: When working with strong solutions of acids or bases or other caustic or corrosive materials, always wear a full face mask. When working with caustic or corrosive gases or vapors, a full face mask will not protect the eyes or prevent inhaling the material. A full face respirator is required. /Hydrochloric acid/
Vendor recommendations concerning the protective qualities of materials are as follow: neoprene, nitrile, chlorinated polyethylene, and polyvinyl alcohol received A (highest) or B (good) ratings from three or more venders, Natural rubber and nitrile/polyvinyl chloride received A (highest) or B (good) ratings from less than three vendors, B (good) and C (fair) ratings, with B's predominating, from several vendors, Neoprene/styrene-butadiene rubber and polyurethane received B (good) and C (fair) ratings, with C's predominating, from several vendors, C (fair) or D (poor) ratings from less than three vendors.
Breakthrough times of chlorinated polyethylene are greater than one hour reported by (normally) two or more testers. There are some data suggesting breakthrough times of polycarbonate to be approximately an hour or more.
Breakthrough times of natural rubber, neoprene, nitrile, and polyvinyl chloride are greater than one hour reported by (normally) two or more testers. Breakthrough times of natural rubber and neoprene are greater than one hour reported by (normally) two or more testers. There are some data suggesting the breakthrough times of nitrile, polyvinyl chloride, Viton, and Saranex to be approximately an hour or more. /Hydrochloric acid, 30-70%/
Workshops in which hydrochloric acid is frequently handled should be equipped with emergency showers and eyewash equipment, etc. /Hydrochloric acid/
Wear appropriate personal protective clothing to prevent skin contact. /Hydrochloric acid solution/
Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen. /Hydrogen chloride/
Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite. /Hydrogen chloride/
Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. /Hydrochloric acid solution/
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities should provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] /Hydrochloric acid solution/
Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating. /Hydrogen chloride/
Respirator Recommendations: Up to 50 ppm: (Assigned Protection Factor = 10) Any chemical cartridge respirator with cartridge(s) providing protection against the compound of concern. Substance reported to cause eye irritation or damage; may require eye protection./(Assigned Protection Factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against the compound of concern./(Assigned Protection Factor = 25) Any powered, air-purifying respirator with cartridge(s) providing protection against the compound of concern. Substance reported to cause eye irritation or damage; may require eye protection./(Assigned Protection Factor = 10) Any supplied-air respirator. Substance reported to cause eye irritation or damage; may require eye protection./(Assigned Protection Factor = 50) Any self-contained breathing apparatus with a full facepiece. /Hydrogen chloride/
Respirator Recommendations: Emergency or planned entry into unknown concentrations or IDLH conditions: (Assigned Protection Factor = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode./(Assigned Protection Factor = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus. /Hydrogen chloride/
Respirator Recommendations: Escape: (Assigned Protection Factor = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted acid gas canister/Any appropriate escape-type, self-contained breathing apparatus. /Hydrogen chloride/
Avoid contact by leakage or otherwise with all common metal. PVA not recommended for gloves; eye protectors and rubberized clothing should be worn in spill area. Respiratory equipment may be necessary and should not be constructed of materials susceptible to rapid corrosion by acid. /Hydrochloric acid/
Personal Protection: Wear positive pressure self-contained breathing apparatus. Wear appropriate chemical protective clothing. /Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
Personal Protection: Wear appropriate chemical protective gloves, boots and goggles. If contact with the material anticipated, wear appropriate chemical protective clothing. /Hydrochloric acid//
Compatible protective equipment construction materials include: Natural rubber, neoprene, nitrile rubber, nitrile rubber/polyvinyl chloride, chlorinated polyethylene, polyvinyl chloride. /Hydrochloric acid; Hydrogen chloride, anhydrous; Hydrogen chloride, refrigerated liquid/
【Specification】

?Hydrogen chloride (CAS NO.7647-01-0) is also named as 4-D Bowl Sanitizer ; Acide chlorhydrique ; Acide chlorhydrique [French] ; Acido clorhidrico ; Acido clorhidrico [Spanish] ; Acido cloridrico ; Acido cloridrico [Italian] ; Anhydrous hydrochloric acid ; Aqueous hydrogen chloride ; Bowl Cleaner ; Caswell No. 486 ; Emulsion Bowl Cleaner ; HSDB 545 ; Hydrochloric acid ; Now South Safti-Sol Brand Concentrated Bowl Cleanse with Magic Actio ; Percleen Bowl and Urinal Cleaner ; Spirits of salt ; UN 1050 (anhydrous) ; UN 1789 (solution) ; UN 2186 (refrigerated liquefied gas) ; UNII-QTT17582CB ; Varley Poly-Pak Bowl Creme ; Wuest Bowl Cleaner Super Concentrated . Hydrochloric acid is soluble in water with evolution of heat. It is a highly corrosive, strong mineral acid. Reacts exothermically with carbonates (including limestone and building materials containing limestone) and hydrogen carbonates to generate carbon dioxide. Reacts rapidly and exothermically with bases of all kinds (including amines and amides). Reacts with many metals (including aluminum, zinc, calcium, magnesium, iron, tin and all of the alkali metals) to generate flammable hydrogen gas. Reacts violently with acetic anhydride, 2-aminoethanol, ammonium hydroxide, calcium phosphide, chlorosulfonic acid, 1,1-difluoroethylene, ethylenediamine, ethyleneimine, oleum, perchloric acid, b-propiolactone, propylene oxide, silver perchlorate/carbon tetrachloride mixture, sodium hydroxide, uranium(IV) phosphide, vinyl acetate, calcium carbide, rubidium carbide, cesium acetylide, rubidium acetylide, magnesium boride, mercury(II) sulfate [Lewis]. Reacts with sulfides, carbides, borides, and phosphides to generate toxic or flammable gases. Concentrations of 1,000 to 2,000 ppm are dangerous, even for brief exposures. More severe exposures will result in serious respiratory distress and prolonged exposures will result in death.

【Report】

EPA Extremely Hazardous Substances List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

【Disposal Methods】
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Pesticide disposal: Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. Container disposal:- Triple rinse (or equivalent). Then offer for recycling or reconditioning, or puncture and dispose of in a sanitary landfill, or incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke. /Emulso Germicidal Bowl Cleaner Disinfectant/
This pesticide is toxic to fish and aquatic organisms. Do not discharge effluent containing this product into lakes, streams, ponds, estuaries oceans or other waters unless in accordance with the requirements of the National Pollutant Discharge Elimination System (NPDES) permit and the permitting authorith has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authonty For guidance contact your State Water Board or Regional Office of the EPA. /Emulso Germicidal Bowl Cleaner Disinfectant/
Neutralization: Neutralize with limestone (CaCO3), soda ash (Na2CO3) or slaked lime (Ca(OH)2). Flushing to sewer with high dilution depends on allowable neutral salt concn in effluent water. Consider use of waste acid to neutralize alkaline wastes.

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

Produced as a by-product from the oxychlorination and/or oxyhydrochlorination of org materials.
By reaction of sodium chloride or, in some cases, potassium chloride with sulfuric acid in muffle or mechanical furnace at temp up to 600 deg C; by Meyer process in which sodium bisulfite is reacted with sodium chloride at 400-800 deg C; by the Hargreaves process using sulfur dioxide, salt, and steam in an exothermic reaction; by synthesis, in which hydrogen is burnt in chlorine; as a byproduct of the chlorination of organic compounds. These processes are followed by the elimination of suspended solids, cooling, condensation and purification. /Hydrochloric acid/
Hydrogen chloride is produced by the direct reaction of hydrogen and chlorine, by reaction of metal chlorides and acids, and as a by-product from many chemical manufacturing processes such as chlorinated hydrocarbons.
Hydrochloric acid (HCL) is obtained from four major sources: As a byproduct in the manufacture of organic chemicals; by the direct reaction of salt and sulfuric acid (Manheim process); by reacting salt, sulfur dioxide, oxygen, and water (Hargreaves process); and by burning of chlorine with hydrogen gas. Byproduct sources have accounted for 87-92% of reported HCL production in recent years, with salt accounting for 3-4%, and chlorine burning 5-10%.
Produced industrially by the interaction of sodium chloride and sulfuric acid; from sodium chloride, sulfur dioxide, air and water vapor; or as a by-product of the synthesis of chlorinated hydrocarbons. /Hydrogen chloride gas/
About 90% of hydrochloric acid is a byproduct from the production of chlorinated solvents, fluorocarbons, isocyanates, organics, magnesium, and vinyl chloride monomer.
The simplest method for producing hydrogen chloride is direct synthesis from the elements, which yields a very pure product. ... Industrial production involves the use of a burner; chlorine and hydrogen are fed by separate concentric tubes into the combustion chamber. After ignition, the chlorine burns in the hydrogen with a quiet, very hot flame at greater than 2000 deg C. ... A cooling section of appropriate size and shape is connected to the combustion chamber.
U.S. Exports

(1984) 1.54X10+10 g
U.S. Imports

(1972) 6.8X10+10 G
(1975) 3.90X10+10 G
(1984) 8.78X10+10 g
U.S. Production

(1972) 2.12X10+12 G
(1975) 1.83X10+12 G
Production capacity in 1993 was about 2.92 million metric tons.
(1984) 2.48X10+12 g
(1990) 6.03 billion lb
(1991) 6.60 billion lb
(1992) 7.13 billion lb
(1993) 6.45 billion lb
(1994) 7.47 billion lbs
(1995) 7.33 billion lbs
Worldwide production of hydrochloric acid 1994-2005 (in selected regions) Hydrochloric acid production around the world 1994-2005 (thousand tonnes) Year/Location USA Europe Canada Japan China 1994 3,405 1,013 134 2,370 not reported 1995 3,541 1,248 138 2,469 not reported 1996 3,733 1,540 147 2,416 not reported 1997 4,145 1,907 142 2,539 3,843 1998 4,226 1,830 149 2,408 3,801 1999 4,081 2,098 157 2,448 3,960 2000 4,278 2,050 155 2,494 4,454 2001 3,969 2,608 143 2,342 4,705 2002 4,037 4,142 151 2,317 4,926 2003 4,179 3,784 153 2,363 5,276 2004 5,301 5,165 149 2,324 6,007 2005 4,406 (preliminary data) 6,300 (est) 142 2,308 6,582
Production volumes for non-confidential chemicals reported under the Inventory Update Rule. Year Production Range (pounds) 1986 >100 million - 500 million 1990 >10 million - 50 million 1994 >10 million - 50 million 1998 >1 billion 2002 >1 billion
Consumption Patterns

12% USED IN STEEL PICKLING; 88% IN OTHER MISC APPLICATIONS (1974).
Brine treatment for chloralkali 12%, steel pickling 11%, food, including corn syrup, 11%, calcium chloride 9%, oil well acidulation 8%, chlorine 4%, swimming pools 2%, miscellaneous including metal recovery from used catalysts, pH control, sludge removal, sand and clay purification, and production of inorganics like sodium chlorate, metal chlorides, activated carbon and iron oxide pigments, and organics like polycarbonate resins, bisphenol-A, polyvinyl chloride resins and synthetic glycerine 43%.
Consumption in 1993 was about 1.57 million metric tons (100% basis). /Muriatic acid/
Chemical Profile: Hydrochloric Acid. Demand: 2003: 2.813 million short tons; 2004: 3.574 million tons; 2008: 3.665 million tons, projected. Obtaining accurate supply and demand figures for HCl is problematic. There is confusion in what data to count because of the many different HCl source types, some of which recycle HCl back into the process. About 60 percent of the HCl produced (excluding coproduct from VCM /vinyl chloride monomer/) in recent years has gone to serve the merchant market.
Chemical Profile: Hydrochloric Acid. Uses. Uses of Hydrochloric Acid (2005) [excluding HCl consumed in EDC /ethylene dichloride/ production] Enduse Percent (%) Organic chemicals 28 Inorganic chemicals 13 Food processing 12 Brine treatment 10 Steel pickling 8 Oil well acidulation 4 Swimming pools 2 Miscellaneous, including semiconductors, catalyst for chemical syntheses, mineral processing and regeneration of ion-exchange resins used for water treatment 23
【Usage】

In the production of chlorides, refining ore in the production of tin and tantalum, for the neutralization of basic systems, as laboratory reagent, hydrolyzing of starch and proteins in the preparation of various food products, pickling and cleaning of metal products, as catalyst and solvent in organic synthesis, for oil- and gas-well treatment, in removing scale from boilers and heat-exchange equipment, pharmaceutic aid (acidifier).

【Sampling Procedures】
PASSIVE MEMBRANE DOSIMETERS REQUIRING NO INDIVIDUAL CALIBRATION AND HAVING NO MOVING PARTS ARE USED IN CONNECTION WITH ION ELECTRODES FOR DETECTING HYDROGEN CHLORIDE GASES IN AIR @ CONCN LESS THAN 24 PPM.
ANALYTE: HYDROGEN CHLORIDE; MATRIX: AIR; RANGE: 3.5-14 MG/CU M; PROCEDURE: BUBBLER COLLECTION IN 0.5 MOLAR SODIUM ACETATE, ION SPECIFIC ELECTRODE.
ANALYTE: HYDROGEN CHLORIDE; MATRIX: AIR; RANGE: 0.14-14 MG/CU M (15-L AIR SAMPLE); PROCEDURE: SILICA GEL TUBE COLLECTION, ELUENT DESORPTION, ION CHROMATOGRAPHY.

Biomedical Effects and Toxicity

【Therapeutic Uses】
... IN TREATMENT OF GASTRIC ACHLORHYDRIA. ... FREE ACID IS ADMIN AS DILUTED HYDROCHLORIDE ACID (10%) IN DOSE OF 5 TO 10 ML IN 125 TO 250 ML OF WATER, OFTEN IN SEVERAL DIVIDED DOSES @ 15-MIN INTERVAL. IT MUST BE SIPPED THROUGH A TUBE.
VET: INTERNALLY ... IN ACHLORHYDRIA & HYPOCHLORHYDRIA ESP IN PUPS & IN SOME DOGS ... UP TO 2 YR OF AGE. ... ORALLY, IN RUMEN ATONY OF CATTLE ESP IN THOSE CASES ASSOC WITH ACETONEMIA. ... EFFECTIVE TOPICALLY ON MOLD SPORES (1-2%) & ANTIBACTERIAL AGAINST MANY ORGANISMS. ...
PHARMACEUTIC AID (ACIDIFYING AGENT); VET: HAS BEEN USED AS GASTRIC ACIDIFIER.
MEDICATION (VET): ANTISEPTIC
MEDICATION (VET): INTERNALLY.
/EXP/ /The objectives of this study were/ to evaluate the tissue coagulation and anticancer effects of hydrochloric acid compared with ethanol and acetic acid and to assess the in situ destructive effects and safety of CT mediated percutaneous hydrochloric acid injection therapy (PHAIT). IC50 of gastric juice and 10% diluted hydrochloric acid against cancer cell lines in vitro were determined. Coagulated necrotic area of hydrochloric acid was observed in vitro and in vivo using pig liver. The coagulated effects of 6 mol/L hydrochloric acid solution (HAS6) on pig liver and muscle were compared with 50% acetic acid and anhydrous alcohol. Thirty patients with 38 lesions of liver cancer were treated by the CT mediated intratumor injection of HAS6. The in situ destructive rate, CT evaluation, PET, histopathology, survival and side effects were observed. The IC50 of gastric juice and 10% diluted hydrochloric acid against cancer cell lines were as similar as approximately 0.05-0.07% in concentration. Coagulated area of liver tissue by 1 mL of 1.5-12 mol/L hydrochloric acid was 18.3-53.4 mm in diameter. The globular hoariness coagulation area with a clear-cut borderline separated from normal tissue was produced. The 6.0 mol/L hydrochloric acid shows a larger coagulation dimension with a clear boundary, 15 times of anhydrous alcohol and 5 times of 50% acetic acid. No toxicities in the routine local injection dosages were found. Clinically, the patients received 73 sessions of PHAIT; CT scan shows a low density area with gas that did not enhance by CT scan shown 24 hrs later. A good necrosis and destruction rate of cancer was obtained by PET, biopsy and AFP measurement. One year, 2-year and 3-year survival rates were 100, 90 and 85%, respectively. Nine cases survived more than 3 years, and 2 cases for more than 4 years. No change in the heart, liver and kidney functions were found. Main side effects were slight pain, lower fever, etc. The 6 mol/L hydrochloric acid is an effective endogenetic protein coagulator; the cancer tissue coagulated effect of HAS6 was superior to 50% acetic acid and anhydrous alcohol. [Weijian F et al; Gan To Kagaku Ryoho 33 (12): 1852-6 (2006)]
【Biomedical Effects and Toxicity】
Following intravenous infusion of 0.15 M hydrochloric acid into rats (50 ml/kg body weight/hour) and dogs (20 ml/kg body weight/hour), urinary excretion of the chloride ion was increased in both species.
Acute metabolic acidosis ... decreased proximal fluid reabsorption and increased the fractional delivery of sodium and calcium to the distal tubules, but not to the final urine. In comparison with normal dogs, dogs with chronic metabolic acidosis showed an increase in proximal fluid reabsorption and a dissociation of calcium from sodium reabsorption more distally, leading to an increase delivery of calcium relative to the sodium at the distal tubule and in the final urine. [Sutton RA et al; Kidney Int 15 (5): 520-33 (1979)] PubMed Abstract
The authors encountered a case of hydrochloric acid (HCl) poisoning, thought to be caused by oral ingestion of concentrated HCl. Coagulation of the surface of the tongue and the mucosa of the pharynx, esophagus, and stomach were observed at forensic autopsy. An overabundance of Cl- was found in the gastric contents, corresponding to 8.19 mL of concentrated HCl. This was suggested to be a lethal oral dose of concentrated HCl, and the cause of death was determined to be HCl poisoning. Measuring the pH and concentrations of various ions in body fluids and contents of the alimentary tract enabled postmortem diffusion of HCl to be determined. [Yoshitome K et al; J Anal Toxicol 30 (4): 278-80 (2006)] PubMed Abstract

Environmental Fate and Exposure Potential

【Environmental Fate/Exposure Summary】
TERRESTRIAL FATE: If released to soil, hydrogen chloride will evaporate from dry soil surfaces and dissociate into chloride and hydronium ions in moist soil(1).
AQUATIC FATE: If released to water, hydrogen chloride dissociates readily in water to chloride and hydronium ions, decreasing the pH of the water(1). A Henry's law constant of 2.04X10+6 mol/L atm (4.90X10-10 cu m atm/mol) has been reported for hydrochloric acid(2). This Henry's Law constant indicates that hydrochloric acid is expected to be essentially nonvolatile from water surfaces(3).
ATMOSPHERIC FATE: Hydrogen chloride is removed from air by wet deposition as chloride salts with an atmospheric lifetime of 1-5 days(1).

Supplier Location

Top Suppliers

Diamond member Nanjing Chemlin Chemical Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-25-83697070
Diamond member MALOKO MALAPA TRADING LTD
Country:South AfricaSouth Africa
Business Type:Trading Company
Telephone:27-063-0940547
Hebei Hongyuan Kang Import and Export Trade Co., Ltd
Country:ChinaChina
Business Type:Trading Company
Telephone:86-311-82179998
Finetech Industry limited.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-27-87465837
shijiazhuang xinlongwei chemical co,ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-155-11419711
Jinan Haohua Industry Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:0086-531-58773055
Nine Continent Company
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-512-67065322809
Qingdao Hisea Chem Co.,Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-0532-8670801
Hebei Tongsen Trade Co.,Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-312-5958026
Gulf star llc
Country:OmanOman
Business Type:Distributor/Wholesaler
Telephone:968-917200813-98166143

Quick Search

Cas    Name

Related products