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Polyvinylpyrrolidone - iodine complex(CAS No. 25655-41-8)

Polyvinylpyrrolidone - iodine complex (C6H9NO)x.xI2 (cas 25655-41-8) Molecular Structure

25655-41-8 Structure

Identification and Related Records

【Name】
Polyvinylpyrrolidone - iodine complex
【Iupac name】
1-ethenylpyrrolidin-2-one; molecular iodine
【CAS Registry number】
25655-41-8
【Synonyms】
Tegodyne
Poly(1-(2-Oxo-1-Pyrrolidinyl)Ethylene)-Iodine Complex
Povidoneiodine
1-Ethenyl-2-pyrrolidinone homopolymer compound with iodine
1-Vinyl-2-pyrrolidinone polymer, compd. with iodine
2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine
Argentyne
【EINECS(EC#)】
215-034-3
【Molecular Formula】
(C6H9NO)x. xI2 (Products with the same molecular formula)
【Molecular Weight】
364.95
【Inchi】
InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;
【Canonical SMILES】
C=CN1CCCC1=O.II

Chemical and Physical Properties

【Appearance】
A red-brown crystalline powder
【Melting Point】
300℃
【Boiling Point】
217.6oC at 760 mmHg
【Vapour】
0.132mmHg at 25°C
【Flash Point】
93.9 oC
【Solubilities】
soluble
【Color/Form】
Yellowish-brown amorphous hygroscopic powder
【Stability】
Stable under normal temperatures and pressures.
【Storage temp】
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Store in air tight containers.
【Computed Properties】
Molecular Weight:364.9507 [g/mol]
Molecular Formula:C6H9I2NO
H-Bond Donor:0
H-Bond Acceptor:1
Rotatable Bond Count:1
Tautomer Count:2
Exact Mass:364.87735
MonoIsotopic Mass:364.87735
Topological Polar Surface Area:20.3
Heavy Atom Count:10
Formal Charge:0
Complexity:120
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:2

Safety and Handling

【Safety Statements 】
S24/25
【Safety】
Moderately toxic by subcutaneous and intravenous routes. Mildly toxic by ingestion. Human systemic effects by skin contact: hemorrhage and dermatitis. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx and I?.
【Formulations/Preparations】
Generic. Douche; gel; solution. Betadine (Purdue Frederick). Douch 10% in 15, 30, 120, and 240 ml containers; gel 10% in 18 g containers; solution 10% in 15, 30, and 240 ml containers.
Generic. Ointment in 1, 1.2, 1.5 30, 100, and 500 g containers; solution in 15, 30, 60, 120, 240, 480, 960, and 3,840 ml containers; ACU-dyne (Acme United). Ointment in 1.2, 2.7, and 454 g containers; Betadine (Purdue-Fredrick). Aerosol spray in 90 ml containers; aerosol foam (Helafoam solution) in 270 g containers; cream in 15 g containers; ointment in 0.94, 3.8, 30, and 454 g containers; solution in 15, 30, 120, 240, 480, 948, and 3,840 ml containers; concentrate (for whirlpool) in 3,840 ml containers; Efodine (Fougera). Ointment in 0.94, 30, and 454 g containers; Pharmadine (Sherwood). Ointment in 1, 1.5, 30, and 454 g containers; solution in 15, 120, 240, 480, 948, and 3,840 ml containers; solution (for whirlpool) in 3,840 ml containers; Polydine (Century). Ointment in 30, 120, and 454 g containers; solution in 30, 120, 240, and 3,792 ml containers.
【Exposure Standards and Regulations】
The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed drug products, incl povidone-iodine, approved on the basis of safety and effectiveness by FDA under sections 505 and 507 of the Federal Food, Drug, and Cosmetic Act.
【Reactivities and Incompatibilities】
A mixture of equal parts of providone solution and hydgrogen peroxide 3% exploded about 100 min after dispensing.

Use and Manufacturing

【Usage】

A topical antiseptic.

Biomedical Effects and Toxicity

【Pharmacological Action】
- Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
【Therapeutic Uses】
Anti-Infective Agents, Local; Iodophors
Povidone-iodine solution (1% available iodine) was effective against Mycobacterium tuberculosis in a modified Kelsey-Sykes capacity tests.
Evidence to suggest that rectal antisepsis with povidone-iodine 10% solution before transrectal prostatic biopsy reduces the risk of contamination and the incidence of bacteraemia.
The use of a mixture of equal parts of povidone-iodine ointment 10% (Betadine) and honey for the treatment of abrasions and varicose ulcers.
Good or excellent symptomatic relief was reported by 20 elderly patients with decubitus and stasis ulcers treated with povidone-iodine solution and ointment thrice daily.
For the treatment of contaminated wounds, pre-operative preparation of the skin and vagina, infections of the mouth, herpes infections, oral and vaginal candidiasis, vaginal trichomoniasis, acne vulgaris, and other pyogenic or seborrhoeic infections of the scalp or skin. It has also been used in the treatment of eczematoid ringworm.
Sixty-eight women with cervical erosions were treated with povidone-iodine pessaries, 400 mg or hydrargaphen pessaries 10 mg each night for up to 4 months. Of the 34 patients in each group 20 responded well to treatment with povidone-iiodine, with 5 defaulting, and 17 responded to hydrargaphen, with 3 defaulting. The difference between the 2 preparations used was not considered to be significant, but toxicity associated with the absorption of mercury during extended therapy with hydrargaphen should be considered.
Topical anti-infective
【Biomedical Effects and Toxicity】
Topical vaginal application of povidone-iodine elevates serum concentrations of iodine.

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