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Indapamide(CAS No. 26807-65-8)

Indapamide C16H16ClN3O3S (cas 26807-65-8) Molecular Structure

26807-65-8 Structure

Identification and Related Records

【Name】
Indapamide
【CAS Registry number】
26807-65-8
【Synonyms】
Lozol (TN)
Natrix
Tertensif
4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-3-yl)-3-sulfamoyl-benzamide
Indapamide[3-(aminosulfonyl)-4-chloro-N-(2.3-dihydro-2-methyl-1H-indol-1-yl)benzamide]
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide
S 1520
Lozol
SE 1520
Indapamide (JAN/USP)
Prestwick_606
Natrix (TN)
Benzamide,3-(aminosulfonyl)-4-chloro-N-(2,- 3-dihydro-2-methyl-1H-indol-1-yl)-
Indapamid
Indapamide [GMP]
【EINECS(EC#)】
248-012-7
【Molecular Formula】
C16H16ClN3O3S (Products with the same molecular formula)
【Molecular Weight】
365.83
【Inchi】
InChI=1/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
【Canonical SMILES】
CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
【MOL File】
26807-65-8.mol

Chemical and Physical Properties

【Appearance】
Crystalline Solid
【Density】
1.51 g/cm3
【Melting Point】
160-162oC
【Refractive Index】
1.693
【Solubilities】
Insoluble
【Stability】
Stable at normal temperatures and pressures.
【Computed Properties】
Molecular Weight:365.83454 [g/mol]
Molecular Formula:C16H16ClN3O3S
XLogP3-AA:2.9
H-Bond Donor:2
H-Bond Acceptor:5
Rotatable Bond Count:3
Tautomer Count:2
Exact Mass:365.06009
MonoIsotopic Mass:365.06009
Topological Polar Surface Area:101
Heavy Atom Count:24
Formal Charge:0
Complexity:580
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:3
Feature 3D Donor Count:2
Feature 3D Ring Count:3
Effective Rotor Count:4.6
Conformer Sampling RMSD:0.8
CID Conformer Count:31

Safety and Handling

【Safety】

Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Cl?, SOx, and NOx.

【Specification】

?Indapamide (CAS NO.26807-65-8), its Synonyms are 3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide ; 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide ; Arifon ; Bajaten ; Cormil ; Damide ; Fludex ; Indaflex ; Indamol ; Indapamida ; Ipamix ; Lozol ; Natrilix ; Noranat ; Pressurai ; Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)- (9CI) ; Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-l-yl)- ; Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl- .

Use and Manufacturing

【Usage】

Used as an antihypertensive. Diuretic

Biomedical Effects and Toxicity

【Pharmacological Action】
- Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
- Agents that promote the excretion of urine through their effects on kidney function.

Supplier Location

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Finetech Industry limited.
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