Identification and Related Records
- 【Name】
- Atracurium besylate
- 【Registry number】
- 64228-81-5 (CAS DataBase Reference)
- 【Synonyms】
-
Tracrium
Atracurii besilas [INN-Latin]
Atracurium Besilate injection
Besilate datracurium [INN-French]
Isoquinolinium, 2,2-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate
Atracurium besilate
Track detectorsTracrium
BW 33A
Tracrium (TN)
Besilato de atracurio [INN-Spanish]
Atracurium besylate (USP)
Atracurii besilas
Atracurium besy
- 【EINECS(EC#)】
- 264-743-4
- 【Molecular Formula】
- C53H72N2O12.2(C6H5O3S) (Products with the same molecular formula)
- 【Molecular Weight】
- 1243.47918
- 【Inchi】
- InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2
- 【InChIKey】
- XXZSQOVSEBAPGS-UHFFFAOYSA-L
- 【Canonical SMILES】
- C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-]
Chemical and Physical Properties
- 【Appearance】
- white to yellowish-white powder, slightly hygroscopic
- 【Melting Point】
- 85-90℃
- 【Water】
- H2O: ~27 mg/mL
- 【Solubilities】
- H2O: ~27 mg/mL
- 【Color/Form】
- white
- 【Storage temp】
- 2-8°C
- 【Computed Properties】
- Molecular Weight:1243.47918 [g/mol]
Molecular Formula:C65H82N2O18S2
H-Bond Donor:0
H-Bond Acceptor:18
Rotatable Bond Count:26
Exact Mass:1242.500405
MonoIsotopic Mass:1242.500405
Topological Polar Surface Area:258
Heavy Atom Count:87
Formal Charge:0
Complexity:1560
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:4
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:3
Safety and Handling
- 【Safety】
-
WGK Germany: 3
- 【Specification】
-
?Atracurium besylate , its cas register number is 64228-81-5. It also can be called 2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate ; Tracrium ; Atracurium besylate [USAN:BAN] ; 2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate, pentamethylene ester ; Atracurii besilas ; Atracurii besilas [INN-Latin] ; Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate ; Pentamethylen bis(3-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-2-isochinolyl)propionat) bis(benzolsulfonat) .It is a white to yellowish-white powder, slightly hygroscopic.
Use and Manufacturing
- 【Usage】
-
A neuromuscular blocking agent
Biomedical Effects and Toxicity
- 【Pharmacological Action】
- - Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
- Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
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