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Cefotaxime sodium(CAS No. 64485-93-4)

Cefotaxime sodium C16H16N5NaO7S2 (cas 64485-93-4) Molecular Structure

64485-93-4 Structure

Identification and Related Records

【Name】
Cefotaxime sodium
【Iupac name】
sodium
(6S,7S)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.
2.0]oct-2-ene-2-carboxylate
【CAS Registry number】
64485-93-4
【Synonyms】
cefotaxim sodium salt
Cefotaxime Sodium (Sterile)
Cefotaxime free acid
RU 24662
Liquiritin
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
sodium [6R-[6α,7β(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Sodium (6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate 7(sup 2)-(Z)-(O-methyloxime), acetate (ester)
Claforan (TN)
Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
Cefotaxime sodium (JP14/USP)
HR 756
Claforan sodium
Cefotaxime sodium salt
sodium (6R,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
63527-52-6
Cefotaxime Sodium. Sterile
Cefotaxima [INN-Spanish]
Cefotaxime sodium [USAN:JAN]
sodium (6R,7R)-3-(acetyloxymethyl)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Sodium (6R-(6alpha,7beta(Z)))-3-(acetoxymethyl)-7-((2-aminothiazol-4-yl)(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
Prestwick_823
RU 24756
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
(+)-Cefotaxime sodium salt
Sodium cefotaxime
Tolycar
(6S,7S)-3-(acetyloxymethyl)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, monosodium salt, (6R-(6alpha,7beta(Z)))-
Cefotaxime Sodium sterile
【EINECS(EC#)】
264-915-9
【Molecular Formula】
C16H16N5NaO7S2 (Products with the same molecular formula)
【Molecular Weight】
477.44731
【Inchi】
InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m0./s1
【InChIKey】
AZZMGZXNTDTSME-XJTDMATHSA-M
【Canonical SMILES】
CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
【Isomers smiles】
CC(=O)OCC1=C(N2[C@H]([C@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)
[O-].[Na+]
【MOL File】
64485-93-4.mol

Chemical and Physical Properties

【Appearance】
White to pale yellow crystalline powder
【Density】
1.8 g/cm3
【Melting Point】
162-163 °C(lit.)
【Refractive Index】
61 ° (C=1, H2O)
【Water】
H2O: aqueous solutions of 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
【Solubilities】
H2O: aqueous solutions of 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
【Color/Form】
white to yellow
【Stability】
Stable. Incompatible with strong oxidizing agents.
【HS Code】
29419000
【Storage temp】
2-8°C
【Computed Properties】
Molecular Weight:477.44731 [g/mol]
Molecular Formula:C16H16N5NaO7S2
H-Bond Donor:2
H-Bond Acceptor:10
Rotatable Bond Count:8
Tautomer Count:14
Exact Mass:477.038884
MonoIsotopic Mass:477.038884
Topological Polar Surface Area:230
Heavy Atom Count:31
Formal Charge:0
Complexity:839
Isotope Atom Count:0
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:1
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:2

Safety and Handling

【Hazard Codes】
Xn: Harmful;
【Risk Statements】
R42/43
【Safety Statements 】
S22;S36;S37
【Safety】

Moderately toxic by intravenous and intramuscular routes. Mildly toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: agranulocytosis. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx, NOx and Na2O.
Hazard Codes:?HarmfulXn,IrritantXi(Harmful)
Risk Statements:
R42/43 (May cause sensitization by inhalation and skin contact )
Safety Statements:
S22:Do not breathe dust??
S36/37 :Wear suitable protective clothing and gloves
WGK Germany: 2

【Specification】

?Cefotaxime sodium , its cas register number is 64485-93-4. It also can be called Claforan ; CTX ; and [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt .

Use and Manufacturing

【Usage】

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group

Biomedical Effects and Toxicity

【Pharmacological Action】
- Substances that reduce the growth or reproduction of BACTERIA.
【Therapeutic Uses】
Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group

Supplier Location

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Telephone:86-27-87465837

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