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Norfloxacin(CAS No. 70458-96-7)

Norfloxacin C16H18FN3O3 (cas 70458-96-7) Molecular Structure

70458-96-7 Structure

Identification and Related Records

【Name】
Norfloxacin
【CAS Registry number】
70458-96-7
【Synonyms】
1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid
AM 715
Amicrobin
Baccidal
Barazan
Barotham
Chibroxin
Chibroxine
Esclebin
Floxacin
Floxacin 400
Fulgram
Gonorcin
Lexinor
Mk 0366
N-Demethylpefloxacin
N-Desmethylpefloxacin
Neofloxacin
Neofloxin
Noflo
Nofocin
Nolicin
Noracin
Noraxin
Norbid
Norflox 400
【EINECS(EC#)】
274-614-4
【Molecular Formula】
C16H18FN3O3 (Products with the same molecular formula)
【Molecular Weight】
319.330823
【Inchi】
InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
【InChIKey】
OGJPXUAPXNRGGI-UHFFFAOYSA-N
【Canonical SMILES】
CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
【MOL File】
70458-96-7.mol

Chemical and Physical Properties

【Appearance】
Off-white to light yellow cryst powder
【Density】
1.344 g/cm3
【Melting Point】
220℃
【Boiling Point】
555.8 °C at 760 mmHg
【Flash Point】
289.9 °C
【Water】
Insoluble
【Solubilities】
Insoluble
【Stability】
Stable at normal temperatures and pressures.
【Storage temp】
2-8°C
【Computed Properties】
Molecular Weight:319.330823 [g/mol]
Molecular Formula:C16H18FN3O3
XLogP3:-1
H-Bond Donor:2
H-Bond Acceptor:7
Rotatable Bond Count:3
Exact Mass:319.13322
MonoIsotopic Mass:319.13322
Topological Polar Surface Area:72.9
Heavy Atom Count:23
Formal Charge:0
Complexity:519
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:3
Feature 3D Donor Count:1
Feature 3D Anion Count:2
Feature 3D Cation Count:3
Feature 3D Ring Count:3
Effective Rotor Count:4.2
Conformer Sampling RMSD:0.8
CID Conformer Count:5

Safety and Handling

【Hazard Codes】
Xn: Harmful;
【Risk Statements】
R20/21/22
【Safety Statements 】
26-37/39
【HazardClass】
IRRITANT
【Safety】

Hazard Codes:?HarmfulXn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: VB2005000

【Specification】

Overdose of?Norfloxacin (CAS NO.70458-96-7):
Treatment of overdose?include emptying of the stomach via induced vomiting or by gastric lavage. In?addition?Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer. Administration of magnesium, aluminum, or calcium containing antacids can reduce the absorption of norfloxacin.

Use and Manufacturing

【Usage】

An antibacterial. Fluorinated quinolone antibacterial

Biomedical Effects and Toxicity

【Pharmacological Action】
- Substances that reduce the growth or reproduction of BACTERIA.
- Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
- Compounds that inhibit cell production of DNA or RNA.
【Therapeutic Uses】
An antibacterial. Fluorinated quinolone antibacterial

Supplier Location

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Telephone:86-25-83697070

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