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Carvedilol(CAS No. 72956-09-3)

Carvedilol C24H26N2O4 (cas 72956-09-3) Molecular Structure

72956-09-3 Structure

Identification and Related Records

【Name】
Carvedilol
【CAS Registry number】
72956-09-3
【Synonyms】
1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano
COREG
DIMITONE
DQ-2466
DILATREND
BM-14190
1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL
1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol
Carvedilo
CarvedilolC24H26N204
Carvediloledmf/Gmpep5
CarvedilolEdmf/Gmp
CarvedilolEp5
【Molecular Formula】
C24H26N2O4 (Products with the same molecular formula)
【Molecular Weight】
406.48
【Inchi】
InChI=1/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
【MOL File】
72956-09-3.mol

Chemical and Physical Properties

【Appearance】
colourless crystalline powder
【Density】
1.25 g/cm3
【Melting Point】
113-117℃
【Boiling Point】
655.2 °C at 760 mmHg
【Flash Point】
350.1 °C
【Solubilities】
Insoluble
【Storage temp】
Store at +4°C

Safety and Handling

【Hazard Codes】
N: Dangerous for the environment;Xn: Harmful;
【Risk Statements】
51/53-36/37/38-20/21/22
【Safety Statements 】
61-36-26
【HazardClass】
IRRITANT
【Safety】

Hazard Codes of Carvedilol (CAS NO.72956-09-3):?DangerousN,HarmfulXn
Risk Statements: 51/53-36/37/38-20/21/22
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 61-36-26
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.?
S36: Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 3077 9/PG 3
RTECS: UA8670000

【Transport】
UN 3077 9/PG 3
【Specification】

?Carvedilol ,?its cas register number is 72956-09-3. It also can be called?(+-)-1-(Carbazol-4-yloxy)-3-((2-(o-
methoxyphenoxy)ethyl)amino)-2-propanol ; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol ;
?2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)- ; BM 14190 ; Carvedilolum ; Coreg ;
?DQ 2466 ; HSDB 7044 ; SKF 105517 ; UNII-0K47UL67F2?.?Carvedilol (CAS NO.72956-09-3) is a?colourless crystalline solid.?Side effects of carvedilol were observed to include nightmares,sleep disturbances and anxiety and panic attacks. This is based on a single case report of a patient already diagnosed with anxiety disorder and using the drug improperly before bedtime at elevated doses.

Use and Manufacturing

【Usage】

A nonselective -adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.

Biomedical Effects and Toxicity

【Biological Activity】
Potent β -adrenoceptor and α 1 -adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 -, β 2 - and α 1 -adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K + (K IR ) channels, voltage-dependent Ca 2+ channels and exhibits antioxidant properties at higher concentrations.
【Therapeutic Uses】
A nonselective -adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.
【Biomedical Effects and Toxicity】
Potent β -adrenoceptor and α 1 -adrenoceptor antagonist (K i values are 0.81, 0.96 and 2.2 nM for β 1 -, β 2 - and α 1 -adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K + (K IR ) channels, voltage-dependent Ca 2+ channels and exhibits antioxidant properties at higher concentrations.

Supplier Location

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Business Type:Manufacturer
Telephone:86-27-87465837

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