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Octanediamide,N1-hydroxy-N8-phenyl-(CAS No. 149647-78-9)

Octanediamide,N1-hydroxy-N8-phenyl- C14H20N2O3 (cas 149647-78-9) Molecular Structure

149647-78-9 Structure

Identification and Related Records

【Name】
Octanediamide,N1-hydroxy-N8-phenyl-
【Iupac name】
N'-hydroxy-N-phenyloctanediamide
【CAS Registry number】
149647-78-9
【Synonyms】
Octanediamide,N-hydroxy-N'-phenyl- (9CI)
N-Hydroxy-N'-phenyloctanediamide
SAHA
Suberoylanilide hydroxamic acid
Zolinza
CCRIS 8456
M344
SAHA cpd
Suberanilohydroxamic acid
UNII-58IFB293JI
【Molecular Formula】
C14H20N2O3 (Products with the same molecular formula)
【Molecular Weight】
264.3202
【Inchi】
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
【InChIKey】
WAEXFXRVDQXREF-UHFFFAOYSA-N
【Canonical SMILES】
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
【MOL File】
149647-78-9.mol

Chemical and Physical Properties

【Appearance】
White Crystalline Solid
【Density】
1.174 g/cm3
【Melting Point】
161-162°C
【Boiling Point】
°Cat760mmHg
【Refractive Index】
1.566
【Flash Point】
°C
【Water】
Soluble in ethanol (0.25 mg/ml), DMSO & DMF (20 mg/ml)
【Solubilities】
Soluble in ethanol (0.25 mg/ml), DMSO & DMF (20 mg/ml)
【Computed Properties】
Molecular Weight:264.3202 [g/mol]
Molecular Formula:C14H20N2O3
XLogP3:1.9
H-Bond Donor:3
H-Bond Acceptor:3
Rotatable Bond Count:8
Tautomer Count:12
Exact Mass:264.147393
MonoIsotopic Mass:264.147393
Topological Polar Surface Area:78.4
Heavy Atom Count:19
Formal Charge:0
Complexity:276
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:2
Feature 3D Donor Count:2
Feature 3D Hydrophobe Count:2
Feature 3D Ring Count:1
Effective Rotor Count:10
Conformer Sampling RMSD:1
CID Conformer Count:144

Use and Manufacturing

【Usage】

 Octanediamide,N1-hydroxy-N8-phenyl- (CAS NO.149647-78-9) is used as a powerful, selective, cell histone deacetylase inhibitors permeable (the HDAC). Display anti-angiogenic and vascular endothelial growth factor interference signal activity in human umbilical vein endothelial cells (endothelial cells).

Biomedical Effects and Toxicity

【Pharmacological Action】
- Substances that inhibit or prevent the proliferation of NEOPLASMS.
- Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.

Supplier Location

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Diamond member Nanjing Bangnuo Biotechnology Co., Ltd.
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Diamond member Hangzhou Dayangchem Co., Ltd.
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Diamond member Hangzhou J&H Chemical Co., Ltd
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Hui Chem Company Limited
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-21-60542966

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