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Rosiglitazone maleate(CAS No. 155141-29-0)

Rosiglitazone maleate C18H19N3O3S.C4H4O4 (cas 155141-29-0) Molecular Structure

155141-29-0 Structure

Identification and Related Records

【Name】
Rosiglitazone maleate
【Iupac name】
(Z)-but-2-enedioic acid;
5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,
3-thiazolidine-2,4-dione
【CAS Registry number】
155141-29-0
【Synonyms】
(+-)-5-(p-(2-(Methyl-2-pyridylamino)ethoxy)benzyl)-2,4-thiazolidinedione maleate (1:1)
Rosiglitazone Maleate [USAN]
Avandia (TN)
2,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-, (2Z)-2-butenedioate (1:1)
RosiglitazoneMaleate
Rosiglitazone maleate (USAN)
Rosiglitazone (base,HCL)
【Molecular Formula】
C18H19N3O3S.C4H4O4 (Products with the same molecular formula)
【Molecular Weight】
473.49892
【Inchi】
InChI=1S/C18H19N3O3S.C4H4O4/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15;5-3(6)1-2-4(7)8/h2-9,15H,10-12H2,1H3,(H,20,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
【InChIKey】
SUFUKZSWUHZXAV-BTJKTKAUSA-N
【Canonical SMILES】
CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O
【Isomers smiles】
CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=C\C(=O)O)\C(=O)O

Chemical and Physical Properties

【Appearance】
off-white solid
【Density】
g/cm3
【Melting Point】
235-240°C
【Boiling Point】
585 °C at 760 mmHg
【Flash Point】
307.6 °C
【Water】
soluble in ethanol
【Solubilities】
soluble in ethanol
【Computed Properties】
Molecular Weight:473.49892 [g/mol]
Molecular Formula:C22H23N3O7S
H-Bond Donor:3
H-Bond Acceptor:9
Rotatable Bond Count:9
Tautomer Count:5
Exact Mass:473.125671
MonoIsotopic Mass:473.125671
Topological Polar Surface Area:171
Heavy Atom Count:33
Formal Charge:0
Complexity:588
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:2

Safety and Handling

【Hazard Codes】
Xi
【Risk Statements】
R20/21/22
【Safety Statements 】
24/25-37/39-26
【Safety】

Hazard Codes?IrritantXi
Risk Statements 20/21/22-36/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R36/38:Irritating to eyes and skin.
Safety Statements 24/25-37/39-26
S24/25:Avoid contact with skin and eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.

Use and Manufacturing

【Usage】

Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- ).

Biomedical Effects and Toxicity

【Pharmacological Action】
- Substances which lower blood glucose levels.

Supplier Location

Top Suppliers

Diamond member Hangzhou Dayangchem Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-88938639
Diamond member shijiazhuang guizheng trade co.,ltd
Country:ChinaChina
Business Type:Trading Company
Telephone:86-312-18103315327
Diamond member Nanjing Bangnuo Biotechnology Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-25-52113793
Diamond member Nanjing Bangnuo Biotechnology Co., Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-1732-7098554
Diamond member Shanghai Do Chemical Co.,Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-21-33758180
Diamond member Wuhan Fortuna Chemical Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:0086-27-59207850
Diamond member Nanjing Chemlin Chemical Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-25-83697070
Diamond member AOPHARM
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-311-66600578
Diamond member Hangzhou J&H Chemical Co., Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-87396430
Hui Chem Company Limited
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-21-60542966

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