Related Searches: 2-Aminopyridine, 3-Aminopyridine, 4-Aminopyridine, 2-methyl-2-butanol, 2-(2-Methoxyphenoxy)ethylamine, View all

2-Aminopyridine(CAS No. 504-29-0)

2-Aminopyridine C5H6N2 (cas 504-29-0) Molecular Structure

504-29-0 Structure

Identification and Related Records

【Name】
2-Aminopyridine
【CAS Registry number】
504-29-0
【Synonyms】
2-pyridylamine
2-Pyridinamine
2-Amino Pyridine
【EINECS(EC#)】
207-988-4
【Molecular Formula】
C5H6N2 (Products with the same molecular formula)
【Molecular Weight】
94.12
【Inchi】
InChI=1/C5H6N2/c6-5-3-1-2-4-7-5/h1-4H,(H2,6,7)
【InChIKey】
ICSNLGPSRYBMBD-UHFFFAOYSA-N
【Canonical SMILES】
C1=CC=NC(=C1)N
【MOL File】
504-29-0.mol

Chemical and Physical Properties

【Appearance】
white to yellow flakes
【Density】
1.107g/cm3
【Melting Point】
59-60℃
【Boiling Point】
204-210℃
【Refractive Index】
1.56552 (65 C)
【Flash Point】
92℃
【Water】
Slightly soluble. 1-5 g/100 mL at 19℃
【Solubilities】
soluble
【Color/Form】
White leaflets or large colorless crystals
WHITE POWDER OR CRYSTALS
White powder, leaflets, or crystals.
Leaflets, or large crystals
【Stability】
Stable under normal temperatures and pressures.
【HS Code】
29333999
【Storage temp】
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
【Spectral properties】
MAX ABSORPTION (ALCOHOL): 234 NM (LOG E= 4.1), 297 NM (LOG E= 3.6); SADTLER REFERENCE NUMBER: 1788 (IR, PRISM), 8199 (IR, GRATING)
IR: 1385 (Coblentz Society Spectral Collection)
UV: 500 (Sadtler Research Laboratories Spectral Collection)
MASS: 28 (Aldermaston, Eight Peak Index of Mass Spectra, UK)
【Computed Properties】
Molecular Weight:94.11454 [g/mol]
Molecular Formula:C5H6N2
XLogP3:0.5
H-Bond Donor:1
H-Bond Acceptor:1
Rotatable Bond Count:0
Tautomer Count:2
Exact Mass:94.053098
MonoIsotopic Mass:94.053098
Topological Polar Surface Area:38.9
Heavy Atom Count:7
Formal Charge:0
Complexity:54
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Feature 3D Acceptor Count:1
Feature 3D Donor Count:1
Feature 3D Cation Count:1
Feature 3D Ring Count:1
Effective Rotor Count:0
Conformer Sampling RMSD:0.4
CID Conformer Count:1

Safety and Handling

【Hazard Codes】
T:Toxic
【Risk Statements】
R25;R36/37/38
【Safety Statements 】
S28;S36/37/39;S38;S45
【HazardClass】
6.1
【Hazard Note】

Toxic/Irritant

【PackingGroup 】
II
【Cleanup Methods】
Cover with 9:1 mixture of sand and soda ash. After mixing, transfer into a paper carton, stuffed with ruffled paper. Burn ... in furnace with afterburner and scrubber.
1. Ventilate area of spill. 2. For small quantities, sweep onto paper or other suitable material, place in appropriate container and burn in safe place (such as a fume hood).
【Transport】
UN 2671
【Fire Fighting Procedures】
Extinguishant: Carbon dioxide, dry chemical, alcohol foam
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. /Aminopyridines/
【Formulations/Preparations】
98% minimum purity and 80% solution in H2O grades.
【DOT Emergency Guidelines】
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Aminopyridines/
/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Aminopyridines/
【Reactivities and Incompatibilities】
Strong oxidizers
【Other Preventative Measures】
BASIC VENTILATION METHODS ARE LOCAL & EXHAUST VENTILATION AND DILUTION OR GENERAL VENTILATION.
MOST OPERATIONS WILL REQUIRE CONTROLS TO PREVENT INHALATION. IN CASES OF ACCIDENTAL SKIN CONTACT, PROMPT, THOROUGH SKIN CLEANSING & CLOTHING CHANGE ARE NECESSARY.
Where exposure ... to 2-aminopyridine or solutions containing 2-aminopyridine may occur, facilites for quick drenching of the body should be provided ... .
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. /Aminopyridines/
Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. /Aminopyridines/
【Protective Equipment and Clothing】
Wear butyl rubber gloves, plastic coveralls, and self-contained breathing apparatus.
Clothing contaminated with 2-aminopyridine should be placed in closed container for storage until it can be discarded or until provision is made for removal of 2-aminopyridine from the clothing. If the clothing is to be laundered or otherwise cleaned ... the person performing the operation should be informed of 2-aminopyridine's hazardous properties.
Depending on the extent of possible contact, workers should be provided with personal protective equipment. A charcoal gas mask canister respirator has been found to be effective against a 2% pyridine concentration at 30 l/min for 1 hr. Rubber and plastic gloves should not be relied upon to prevent skin contact because pyridine and many of its derivatives penetrate these materials ... . /Pyridine, homologs, and derivatives/
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]
Recommendations for respirator selection. Max concn for use: 5 ppm. Respirator Class(es): Any supplied-air respirator. May require eye protection. Any self-contained breathing apparatus with a full facepiece.
Recommendations for respirator selection. Condition: Emergency or planned entry into unknown concn or IDLH conditions: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having a high-efficiency particulate filter. Any appropriate escape-type, self-contained breathing apparatus.
【Octanol/Water Partition Coefficient】
log Kow= 0.48
【Disposal Methods】
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
(a) Dissolve in such combustible solvent as alcohols ... etc. Spray the solution into the furnace with afterburner and scrubber. (b) Pour into a mixture of sand and soda ash (9:1). After mixing, put into a paper carton stuffed full with packing paper to serve as fuel. Burn in the furnace /with afterburner and scrubber/ and stand or position oneself on upwind side.
2-Aminopyridine may be disposed of: 1. By making packages of 2-aminopyridine in paper or other flammable material and burning in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device.

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

Prepared from pyridine and sodamide
U.S. Imports

(1983) 6614 lb
【Usage】

Intermediate in chemical synthesis.

Biomedical Effects and Toxicity

【Pharmacological Action】
- Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
【Biomedical Effects and Toxicity】
It may enter the body through the skin.
PYRIDINE & ITS ALKYL DERIVATIVES ARE ABSORBED FROM GI TRACT, INTRAPERITONEAL CAVITY & LUNGS. PERITONEAL ABSORPTION IS APPARENTLY ONLY SLIGHTLY MORE RAPID & COMPLETE THAN GI ABSORPTION... IN GENERAL THE BASES ARE RAPIDLY ABSORBED THROUGH INTACT SKIN. /ALKYL DERIVATIVES OF PYRIDINE/
MAJORITY OF /PYRIDINE/ DERIVATIVES TESTED ... PENETRATE INTACT GUINEA PIG SKIN READILY. AMINOPYRIDINES, VINYLPYRIDINES & 4-PICOLINE PENETRATE SKIN MOST RAPIDLY & AMYL DERIV & 5-ETHYL-2-METHYLPYRIDINE ARE LEAST READILY ABSORBED. /AMINOPYRIDINES/

Environmental Fate and Exposure Potential

【Environmental Fate/Exposure Summary】
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 45(SRC), determined from a structure estimation method(2), indicates that 2-aminopyridine is expected to have very high mobility in soil(SRC). The pKa of 2-aminopyridine is 6.86(9), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts. Volatilization of 2-aminopyridine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.5X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 2-Aminopyridine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.6X10-2 mm Hg(SRC), determined from a fragment constant method(4). 2-Aminopyridine degrades slowly(6) or is not readily biodegradable(5,8) in soil. In one study, 2-aminopyridine was found to completely degrade in 96 days under both aerobic and anaerobic conditions(7).
AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 45(SRC), determined from an estimation method(2), indicates that 2-aminopyridine is not expected to adsorb to suspended solids and sediment in water(SRC). The pKa of 2-aminopyridine is 6.86(8), indicating that this compound will partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts. Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.5X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), BCFs of 3.0-7.7 and
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-aminopyridine, which has an estimated vapor pressure of 9.6X10-2 mm Hg at 25 deg C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-aminopyridine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 19 hrs(SRC), calculated from its rate constant of 2X10-11 cu cm/molecule-sec at 25 deg C(SRC) determined using a structure estimation method(3). Aminopyridines may be susceptible to photochemical degradation as this class of chemicals absorb above 280 nm(4).

Supplier Location

Top Suppliers

Diamond member Wuhan Fortuna Chemical Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:0086-27-59207850
Diamond member Hangzhou Dayangchem Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-88938639
Diamond member AOPHARM
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-311-66600578
Diamond member Jinlan Pharm-Drugs Technology Co., Limited
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-85829152
Diamond member Nanjing Chemlin Chemical Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-25-83697070
Diamond member Hangzhou J&H Chemical Co., Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-87396430
Finetech Industry limited.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-27-87465837
Shenzhen Simeiquan Biotechnology Co.Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-20-18102838259
Capot Chemical Co., Ltd.
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-571-85586718
Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
Country:ChinaChina
Business Type:Manufacturer
Telephone:86-27-59887160

Quick Search

Cas    Name

Related products

2-AMINOPYRIDINE-D6

2-AMINOPYRIDINE-D6

2-(N-lactityl)aminopyridine

2-(N-lactityl)aminopyridine

2-Aminopyridine-5-thiocarboxamide

6-aminopyridine-3-carbothioamide

5-aminopyridine-2-carbaldehyde

;5-AMINO-PYRIDINE-2-CARBALDEHYDE;5-AMINOPYRIDINE-2-CARBOXALDEHYDE;5-AMINOPICOLINALDEHYDE

4-aminopyridine-2-carbaldehyde

;4-AMINO-2-PYRIDINECARBOXALDEHYDE;4-AMINOPICOLINALDEHYDE;4-AMINO-PYRIDINE-2-CARBALDEHYDE;4-AMINO-2-PYRIDINECARBALDEHYDE

5-Aminopyridine-2-carbothioamide

;5-aminopyridine-2-carbothioamide

2-Aminopyridine-4-boronic acid

(2-AMINO-4-PYRIDYL)BORONIC ACID;2-aminopyridin-4-ylboronic acid;

4-Aminopyridine-2-sulfonic acid

4-Aminopyridine-2-sulfonic acid

2-(N-3'-sialyllactityl)aminopyridine

2-(N-3'-sialyllactityl)aminopyridine

3-Aminopyridine-2-carboxaldehyde-thiosemicarbazone

AIDS-179996; [(3-Aminopyridin-2-yl)methylideneamino]thiourea;3-aminopyridine-2-carbaldehyde thiosemicarbazone;(2E)-2-[(3-aminopyridin-2-yl)methylidene...

Chromium,tris(2-aminopyridine)trichloro- (8CI)

Pyridine,2-amino-, chromium complex