Related Searches: Trimethylchlorosilane

Trimethylchlorosilane(CAS No. 75-77-4)

Directory
1. Identification and Related Records
【Name】
【Registry number】
【Synonyms】
【EINECS(EC#)】
【Molecular Formula】
【MOL File】
【Molecular Weight】
【Inchi】
【InChIKey】
【Canonical SMILES】
2. Chemical and Physical Properties
【Appearance】
【Density】
【Melting Point】
【Boiling Point】
【Refractive Index】
【Flash Point】
【Water】
【Solubilities】
【Color/Form】
【Stability】
【HS Code】
【Storage temp】
【Spectral properties】
【Computed Properties】
3. Safety and Handling
【Hazard Codes】
【Risk Statements】
【Safety Statements 】
【HazardClass】
【Hazard Note】
【Safety】
【PackingGroup 】
【Sensitive】
【Skin, Eye, and Respiratory Irritations】
【Cleanup Methods】
【Transport】
【Fire Fighting Procedures】
【Fire Potential】
【Formulations/Preparations】
【DOT Emergency Guidelines】
【Reactivities and Incompatibilities】
【Other Preventative Measures】
【Protective Equipment and Clothing】
【Specification】
【Disposal Methods】
4. Use and Manufacturing
【Use and Manufacturing】
【Usage】
5. Biomedical Effects and Toxicity
【Pharmacological Action】
【Biomedical Effects and Toxicity】
6. Environmental Fate and Exposure Potential
【Environmental Fate/Exposure Summary】
Trimethylchlorosilane C3H9ClSi (cas 75-77-4) Molecular Structure

75-77-4 Structure

Identification and Related Records

【Name】
Trimethylchlorosilane
【CAS Registry number】
75-77-4
【Synonyms】
Chlorotrimethylsilane
KA 31
KA 31 (silane)
Monochlorotrimethylsilane
Monochlorotrimethylsilicon
NSC 15750
TMCS
TSL 8031
Trimethylchlorosilane
Trimethylsilane chloride
Trimethylsilicon chloride
Trimethylsilyl chloride
【EINECS(EC#)】
200-900-5
【Molecular Formula】
C3H9 Cl Si (Products with the same molecular formula)
【Molecular Weight】
108.642
【Inchi】
InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
【InChIKey】
IJOOHPMOJXWVHK-UHFFFAOYSA-N
【Canonical SMILES】
C[Si](C)(C)Cl
【MOL File】
75-77-4.mol

Chemical and Physical Properties

【Appearance】
colourless liquid
【Density】
0.856
【Melting Point】
-58℃
【Boiling Point】
57℃
【Refractive Index】
1.387-1.389
【Flash Point】
-18℃
【Water】
REACTS
【Solubilities】
REACTS
【Color/Form】
Colorless liquid
【Stability】
Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.
【HS Code】
29310095
【Storage temp】
Store at RT.
【Spectral properties】
Index of refraction = 1.3870 at 25 deg C/D
IR: 5508 (Coblentz Society Spectral Collection)
1H NMR: 3444 (Sadtler Research Laboratories Spectral Collection)
MASS: 61136 (NIST/EPA/MSDC Mass Spectral Database, 1990 version)
13C NMR: 158 (Stothers, Carbon-13 NMR Spectroscopy, Academic Press, New York)
【Computed Properties】
Molecular Weight:108.64206 [g/mol]
Molecular Formula:C3H9ClSi
H-Bond Donor:0
H-Bond Acceptor:0
Rotatable Bond Count:0
Exact Mass:108.016205
MonoIsotopic Mass:108.016205
Topological Polar Surface Area:0
Heavy Atom Count:5
Formal Charge:0
Complexity:28.4
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1
Effective Rotor Count:0
Conformer Sampling RMSD:0.4
CID Conformer Count:1

Safety and Handling

【Hazard Codes】
C:Corrosive
【Risk Statements】
R11;R14;R21;R34
【Safety Statements 】
S16;S26;S36/37/39;S45
【HazardClass】
3
【Hazard Note】

Highly Flammable/Corrosive/Moisture Sensitive

【Safety】
Hazard Codes:T,F,C,Xn
Risk Statements:20/21-36/38-34-21-14-11-37-35-19-40-10
20/21:Harmful by inhalation and in contact with skin
36/38:Irritating to eyes and skin
34:Causes burns
21:Harmful in contact with skin
14:Reacts violently with water
11:Highly Flammable
37:Irritating to the respiratory system
35:Causes severe burns
19:May form explosive peroxides
40:Limited evidence of a carcinogenic effect
10:Flammable
Safety Statements:26-36/37/39-45-16-36/37
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
16:Keep away from sources of ignition - No smoking
36/37:Wear suitable protective clothing and gloves
RIDADR:UN 2924 3/PG 2
WGK Germany:2
HazardClass:3
PackingGroup:II
Hazard Note:Highly Flammable/Corrosive/Moisture Sensitive
HS Code:29310095
Hazardous Substances Data:75-77-4(Hazardous Substances Data)
【PackingGroup 】
II
【Sensitive】
Moisture Sensitive
【Skin, Eye, and Respiratory Irritations】
Strong irritant to tissue.
Irritating to the skin, eyes and mucous membrane. /Chlorosilanes/
... /Trimethylchlorosilane/ and the vapor are corrosive to the eyes, the skin and the respiratory tract ... Inhalation of the vapor may cause lung edema ...
【Cleanup Methods】
Shut off ignition sources. Call fire department. Avoid contact with liquid. Keep people away. Stop discharge if possible. Isolate and remove discharged material. Notify local health and pollution control agencies.
Flush with water. Rinse with sodium bicarbonate or lime soln.
Evacuate danger area! Consult an expert! Collect leaking liquid in sealable dry containers; do not use plastic containers. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Do NOT wash away into sewer. (Extra personal protection: complete protective clothing including self-contained breathing apparatus.)
【Transport】
UN 1298
【Fire Fighting Procedures】
Aqueous film forming foam (AFFF), carbon dioxide, dry sand, special powder. NO hydrous agents. NO water.
If material on fire or involved in fire: Do not extinguish the fire unless flow can be stopped. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. Use water spray to knock-down vapors.
【Fire Potential】
A flammable liquid and very dangerous fire haszard when exposed to heat or flame.
Contact with water applied to adjacent fires produces irritating hydrogen chloride.
Flammable liquid
【Formulations/Preparations】
GRADES OF PURITY: 98+%.
【DOT Emergency Guidelines】
If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. Table of Initial Isolation and Protective Action Distances for Trimethylchlorosilane (when spilled in water) Small Spills (from a small package or small leak from a large package) -------------------- First ISOLATE in all Directions 30 meters (100 feet) Then PROTECT persons Downwind during DAY: 0.1 kilometers (0.1 miles) Then PROTECT persons Downwind during NIGHT: 0.3 kilometers (0.2 miles) ==================== Large Spills (from a large package or from many small packages) -------------------- First ISOLATE in all Directions 90 meters (300 feet) Then PROTECT persons Downwind during DAY: 0.8 kilometers (0.5 miles) Then PROTECT persons Downwind during NIGHT: 2.7 kilometers (1.7 miles)
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Health: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns, or death. ... Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat which will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Fire: Note: Most foams will react with the material and release corrosive/toxic gases. ... Small fires: CO2, dry chemical, dry sand, alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. ... Move containers from fire area if you can do it without risk. Use water spray or fog; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ Spill or Leak: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. ... DO NOT GET WATER on spilled substance or inside containers. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Prevent entry into waterways, sewers, basements or confined areas. Small spills: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal.
/GUIDE 155: SUBSTANCES - TOXIC AND/OR CORROSIVE (FLAMMABLE/WATER-SENSITIVE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
【Reactivities and Incompatibilities】
Reacts with surface moisture to evolve hydrogen chloride, which will corrode common metals & form flammable hydrogen gas.
... They will react with water or steam to produce heat, toxic & corrosive fumes of hydrochloric acid. /Chlorosilanes/
Interaction of the lithium derivative /eg hexafluoroisopropylideneaminolithium/ with a range of chloro- and fluoro-derivatives of arsenic, boron, phosphorus, silicon and sulfur during warming to 25 deg C tended to be violently exothermic in absence of solvent ...
Silane and chlorosilanes can explode when mixed with various halocarbons and ignited.
... Reacts violently with alcohols, amines causing fire and explosion hazard. Attacks many metals in presence of water.
【Other Preventative Measures】
It is good practice to install emergency showers at all strategic locations; these should ... be actuated automatically by pressure on foot plate; bath tubs filled with clean water can also provide valuable service in ... emergency. /Corrosive substances/
CAUTION: Silanes are toxic. Avoid contact with skin and eyes. Use effective fume removal device. /Silanes/
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors. Do not use water on material itself. Neutralize spilled material with crushed limestone, soda ash, or lime.
NO open flames, NO sparks, and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. STRICT HYGIENE ... Local exhaust, or breathing protection ... Do not eat, drink, or smoke during work.
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
【Protective Equipment and Clothing】
... Prevent, from outset, any planned or accidental contact with corrosive substances by utilizing only closed-circuit apparatus ... /otherwise/ corrosion-resistant & impervious suits or overalls, foot, ... hand & arm, ... head, ... eye & face protection ... /should be relied on/. /Corrosive substances/
... Where aprons are used ... these should have bibs; sleeves should be worn outside ... gloves, and ... trouser legs should cover tops of shoes ... When exposure ... is not severe ... barrier creams can often be used instead of gloves. /Corrosive substances/
Acid-vapor-type respiratory protection; rubber gloves; chemical worker's goggles; other protective equipment as necessary to protect skin and eyes.
Face shield, or eye protection in combination with breathing protection.
【Specification】

Colorless liquid
Safety Statements:26-36/37/39-45-16-36/37
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
16:Keep away from sources of ignition - No smoking
36/37:Wear suitable protective clothing and gloves
【Disposal Methods】
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

By Grignard reaction of silicon tetrachloride and methylmagnesium chloride.
REACTION OF SILICON METAL WITH METHYL CHLORIDE AT ELEVATED TEMP USING COPPER CATALYST & SEPARATION FROM RESULTING MIXED METHYLCHLOROSILANES BY FRACTIONAL CRYSTALLIZATION.
U.S. Production

This chemical is listed as a High Production Volume (HPV) (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).
(1977) AT LEAST 4.54X10+8 G
(1982) PROBABLY GREATER THAN 2.27X10+6 G
Production volumes for non-confidential chemicals reported under the Inventory Update Rule. Year Production Range (pounds) 1986 >10 million-50 million 1990 >10 million-50 million 1994 >10 million-50 million 1998 >10 million-50 million 2002 >10 million-50 million
【Usage】

Intermediate for silicone fluids, as a chain terminating agent, imparting water repellency.

Biomedical Effects and Toxicity

【Pharmacological Action】
- Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
【Biomedical Effects and Toxicity】
... Absorption through the skin can be expected ... /and/ is supported by the findings from an acute dermal toxicity study ... although the corrosive nature of chlorotrimethylsilane may have enhanced dermal penetration by breaking down normal barriers.
The substance can be absorbed into the body by inhalation of its vapor and by ingestion.

Environmental Fate and Exposure Potential

【Environmental Fate/Exposure Summary】
TERRESTRIAL FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Volatilization from moist soil surfaces, adsorption to soil and sediment as well as biodegradation are not expected to be important fate processes when compared to decomposition in water. Trimethylchlorosilane may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 234 mm Hg(3).
AQUATIC FATE: All silicon chlorides are immediately and completely hydrolyzed by water(1) and trimethylchlorosilane has been reported to hydrolyze in water releasing hydrochloric acid(2). Due to the rapid decomposition in water volatilization, bioconcentration and biodegradation are not expected to be important fate processes(SRC).
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), trimethylchlorosilane, which has a vapor pressure of 234 mm Hg at 25 deg C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase trimethylchlorosilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 days(SRC), calculated from its rate constant of 4.5X10-13 cu cm/molecule-sec at 25 deg C(SRC) that was derived using a structure estimation method(3). Methyl silanes are transparent to UV radiation >290 nm(4) and therefore trimethylchlorosilane is not expected to undergo direct photolytic degradation(SRC).

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