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Copper(II) oxide(CAS No. 1317-38-0)

Copper(II) oxide CuO (cas 1317-38-0) Molecular Structure

1317-38-0 Structure

Identification and Related Records

【Name】
Copper(II) oxide
【CAS Registry number】
1317-38-0
【Synonyms】
Banacobru OL
C.I. Pigment Black 15
Chrome Brown
Copper monooxide
Copper oxide (CuO)
Copperoxide(CuO)
CuO
Precipitated cupric oxide
Cupric oxide
【EINECS(EC#)】
215-269-1
【Molecular Formula】
CuO (Products with the same molecular formula)
【Molecular Weight】
79.54
【Inchi】
InChI=1/Cu.O/rCuO/c1-2
【InChIKey】
QPLDLSVMHZLSFG-UHFFFAOYSA-N
【Canonical SMILES】
O=[Cu]
【MOL File】
1317-38-0.mol

Chemical and Physical Properties

【Appearance】
black crystalline powder
【Density】
6.315
【Melting Point】
1326℃
【Boiling Point】
2000
【Refractive Index】
2.63
【Flash Point】
无意义
【Water】
insoluble
【Solubilities】
insoluble
【Color/Form】
Black to brownish-black amorphous or crystalline powder or granules
Monoclinic crystals or black powder
Finely divided black particulate dispersed in air.
【Stability】
Stable. Incompatible with reducing agents, hydrogen sulfide, aluminium, alkali metals, finely powdered metals.
【HS Code】
28255000
【Storage temp】
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Spectral properties】
INDEX OF REFRACTION: 2.63 (BETA)
【Computed Properties】
Molecular Weight:79.5454 [g/mol]
Molecular Formula:CuO
H-Bond Donor:0
H-Bond Acceptor:1
Rotatable Bond Count:0
Exact Mass:78.924516
MonoIsotopic Mass:78.924516
Topological Polar Surface Area:17.1
Heavy Atom Count:2
Formal Charge:0
Complexity:2
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:1

Safety and Handling

【Hazard Codes】
Xn:Harmful
【Risk Statements】
R22
【Safety Statements 】
S22
【Safety】

Hazard Codes:?IrritantXiIrritantXn
Risk Statements: 22-37?
R22: Harmful if swallowed
R37: Irritating to respiratory system
Safety Statements: 22-36?
S22: Do not breathe dust
S36: Wear suitable protective clothing
WGK Germany: 1
RTECS: GL7900000
HS Code: 28255000
Poison by intratracheal route.? Explodes when heated with powdered aluminum; anilinium perchlorate; hydrogen; magnesium; phthalic anhydride. Ignites on contact with dichloromethylsilane; hydrogen sulfide; hydrogen trisulfide. Incandescent reaction when heated with boron; rubidium acetylide (at 350°C); potassium; sodium; phospham.

【PackingGroup 】
Z01
【Skin, Eye, and Respiratory Irritations】
Inhalation of copper fume results in the irritation of the upper respiratory tract. ... Contact with copper fumes will also cause irritation of the eyes, nose and throat. /Copper fumes/
【Transport】
无资料?
【Formulations/Preparations】
USEPA/OPP Pesticide Code 042401; Trade Names: Banacobru ol and Black copper oxide.
Wettable micro granular; wettable powder
The pigment known as Scheele's green is a complex mixture of cupric oxide & cupric arsenite. ...
Wolmanac concentrate (70%), for industrial use only, soluble concentrate, 23.8% arsenic pentoxide, 32.25% chromic acid, 12.95% cupric oxide
Wolmanac concentrate (72%), solution-ready to use, 24.48% arsenic pentoxide, 32.20% chromic acid, 13.32% cupric oxide
Osmose K-33 (72%) Wood Preservative, solution-ready to use, 32.5% Arsenic pentoxide, 25.4% Chromic acid, 14.1% Cupric oxide
Osmose K-33-C (72%) Wood Preservative, soluble concentrate, 24.5% arsenic pentoxide, 34.2% chromic acid, 13.3% cupric oxide
Osmose P-50 Wood Preservative, soluble concentrate, 20% chromic acid, 15.5% cupric oxide, 19% phosphoric acid
Osmose K-33 (60%) Wood Preservative, solution-ready to use, 20% arsenic pentoxide, 29.9% chromic acid, 10.5% cupric oxide
Osmose K-33-A (50%) Wood Preservative, 7.3% arsenic pentoxide, 32.2% chromic acid, 10.5% cupric oxide
Boliden-CCA Wood Preservative, soluble concentrate, 34% arsenic pentoxide, 26.5% chromic acid, 14.5% cupric oxide
Boliden Salt K-33, soluble concentrate, 34% arsenic pentoxide, 26.5% chromic acid, 14.5% cupric oxide
CCA Wood Preservative Chromated Copper Arsenate (60%), soluble concentrate, 9.9% arsenic pentoxide, 39.3% chromic acid, 10.8% cupric oxide
CCA Type C Wood Preservative (60%), solution-ready to use, 20.1% arsenic pentoxide, 28.5% chromic acid, 11.4% cupric oxide
【DOT Emergency Guidelines】
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Fire: CAUTION: All these products have a very low flash point. Use of water spray when fighting fire may be inefficient. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Spill or Leak: Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Small spills: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. Keep victim warm and quiet. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Copper based pesticide, liquid, flammable, poisonous; Copper based pesticide, liquid, flammable, toxic; Copper based pesticide, liquid, poisonous, flammable; Copper based pesticide, liquid, toxic, flammable/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at lease 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire: Small fires: Dry chemical, CO2 or water spray. Large fires: Water spray, fog or regular foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Use water spray or fog; do not use straight streams. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Spill or Leak: Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. /Copper based pesticide, liquid, poisonous; Copper based pesticide, liquid, toxic; Copper based pesticide, solid, poisonous; Copper based pesticide, solid, toxic/
【Reactivities and Incompatibilities】
BORON REACTS VIOLENTLY WITH CUPRIC OXIDE AFTER WARMING, MELTING GLASS TUBING.
TITANIUM REACTS VIOLENTLY WITH CUPRIC OXIDE ... WHEN HEATED.
HYDRAZINE REACTS VIGOROUSLY WITH CUPRIC OXIDE.
Cesium acetylene carbide explodes on contact with cupric oxide at 350 deg C.
The reduction of heated cupric oxide by admixed magnesium is accompanied by incandescence and an explosion.
Cupric oxide is reduced when heated with sodium. The reaction proceeds with vivid incandescence.
CUPRIC OXIDE IS REDUCED TO METALLIC COPPER WHEN HEATED WITH POTASSIUM @ TEMP BELOW ITS MP. REACTION PROCEEDS WITH VIVID INCANDESCENCE.
Incompatibilities: Dirubidium acetylide; hydrogen; hydrogen sulfide; metals; phospham; phthalic anhydride.
CuO: Acetylene, zirconium.
Reduction of the heated oxide in a combustion tube by passage of hydrogen caused a violent explosion.
An attempt thermite reaction with aluminum powder and copper(II) oxide ... caused a violent explosion.
A mixture of phthalic anhydride and anhydrous oxide exploded violently on heating.
Interaction with hydroxylamine or hydrazine is vigorous.
A pelleted mixture containing barium acetate, copper(II) oxide and yttrium oxide, ... was heated in a furnace, and a small explosion occurred during the early stages, 'from formation of pyrolysis products'.
Copper oxide and manganese dioxide react at 359 deg C incandescently.
Solutions of sodium hypobromite are decomposed by powerful catalytic action of cupric ions, even as impurities. /Cupric salts/
【Other Preventative Measures】
SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet or significantly contaminated should be removed and replaced.
The worker should wash daily at the end of each work shift.
【Protective Equipment and Clothing】
Wear appropriate eye protection to prevent eye contact.
Wear appropriate personal protective clothing to prevent skin contact.
Recommendations for respirator selection. 1 mg/cu m. Respirator Class(es): Any dust, mist, and fume respirator. Any supplied-air respirator.
Recommendations for respirator selection. 2.5 mg/cu m. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode. Any powered, air-purifying respirator with a dust, mist, and fume filter.
Recommendations for respirator selection. 5 mg/cu m. Respirator Class(es): Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode. Any powered, air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter. Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece.
Recommendations for respirator selection. 100 mg/cu m. Respirator Class(es): Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode.
Recommendations for respirator selection. Condition: Respirator Class(es): Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator that has a full face piece and is operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode.
Recommendations for respirator selection. Condition: Escape from suddenly occurring respiratory hazards: Respirator Class(es): Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any appropriate escape-type, self-contained breathing apparatus.
【Specification】

1、Fire Fighting Measures? of? Cupric oxide (1317-38-0)
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.?
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.?
2、Handling and Storage? of? Cupric oxide (1317-38-0)
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.?
Storage: Store in a cool, dry place. Store in a tightly closed container.?

【Report】

?Copper and its compounds are on the Community Right-To-Know List.

【Disposal Methods】
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Group III Containers (both combustible and non-combustible) that previously held organic mercury, lead, cadmium, arsenic, or inorganic pesticides should be triple rinsed, punctured and disposed of in a sanitary landfill. Non-rinsed containers should be encapsulated and buried at a specially designated landfill site. /Organic mercury, lead, cadmium, arsenic, or inorganic pesticides/
Do not contaminate water by ... disposal of wastes near a body of water. /Copper oxides/

Use and Manufacturing

【Use and Manufacturing】
Methods of Manufacturing

Prep: Glemser, Sauer in Handbook of Preparative Inorganic Chemistry vol 2 G Bauer Ed (Academic Press NY 2nd ed 1965) p 1012.
Ignition of copper carbonate or copper nitrate
IT CAN BE PREPARED BY OXIDATION OF COPPER TURNINGS AT 800 DEG C IN AIR OR OXYGEN ...
Copper(II) hydroxide is easily converted to the oxide by heating.
Copper (air oxidation); copper + ammonia + ammonium carbonate (leaching/steam stripping)
Copper(II) oxide can be prepared pyrometallurigically by heating copper metal above 300 deg C in air; preferably 800 deg C is employed. Molten copper is oxidized to copper(II) oxide when sprayed into an oxygen containing gas. Ignition of copper(II) nitrate trihydrate at about 100-200 deg C produces a black oxide. Basic copper(II) carbonate, when heated above 250 deg C, produces a black oxide if a dense carbonate is employed; a brown material is produced when the light and fluffy carbonate is used. An alkali-free oxide can be prepared by ignition of copper(II) carbonate produced from ammonium carbonate and a copper(II) salt solution. Copper(II) hydroxide when heated above 100 deg C is converted to the oxide. Hydrometallurgy is the most common method for the production of copper(II) oxide. A solution of ammonia and ammonium carbonate in the presence of air effectively leaches metallic copper into solution, the solution is stripped of ammonia and carbon dioxide by steam injection or pressurized boiling to produce black copper(II) oxide.
Prepared by the decomposition of the carbonate or hydroxide at around 300 deg C or by the hydrolysis of hot copper salt solutions with sodium hydroxide. The black product of commerce is most often prepared by evaporation of copper(II) ammonium carbonate solutions or precipitation of copper(II) oxide from hot ammonia solutions by addition of sodium hydroxide. It is less often prepared by pyrometallurgical means. Copper metal heated in air to 800 deg C produces the copper(II) oxide.
U.S. Imports

1.14X10+9 g
(1986) 5359771 lb
【Usage】

Fungicide, insecticide, glaze colorant.

Biomedical Effects and Toxicity

【Pharmacological Action】
- A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
【Biomedical Effects and Toxicity】
The pulmonary uptake of copper oxide /occurred/ in rats exposed to aerosols containing 50-80 mg/cu m. Animals were exposed for 15, 30, 45, or 60 minutes and killed immediately. Another group was exposed for 180 minutes and killed at 0, 3, 6, 12, 18, or 24 hours after exposure. Electron microscopic histologic examination showed that absorption of copper had occurred in animals exposed for 180 minutes. Copper oxide particles penetrated the epithelial cells of alveoli and were found in plasma 6 hours after exposure began. Copper oxide was also observed in the proximal convoluted tubules of the kidney. /Copper oxide/
VET: COPPER SOURCE. 80% COPPER CONTENT. LOW ABSORPTION RATE & HIGH FECAL EXCRETION RATE IN CATTLE & SWINE FEEDING TRIALS. IN GENERAL MONOGASTRIC ANIMALS UTILIZE /CUPRIC OXIDE/ BETTER THAN RUMINANTS. POULTRY UTILIZATION IS SOMEWHERE BETWEEN THE TWO.
Cheviot ewes (mean live weight 50 kg) were given single doses of 0, 2.5, 5, 10, or 20 g cupric oxide particles in gelatin capsules while receiving a diet of marginal copper content based on pelleted oats. After 65 days, liver copper concentrations had increased curvilinearly in relation to dose and all ewes given 10 or 20 g cupric oxide particles showed increases of at least 13.4 mmol/kg dry matter (850 ppm). Liver copper concentrations had generally declined after 85 days but biochemical and histological evidence of copper toxicity was recorded in one ewe which had received 20 g cupric oxide particles. Despite marked variations between individual sheep, a dose of 0.1 g/kg liveweight (5 g) was considered to be safe and did not induce clinical copper toxicity in five sheep of the susceptible North Ronaldsay breed given the same basal diet. [Suttle NF; Res Vet Sci 42 (2): 219-23 (1987)] PubMed Abstract
Crossbred steers, mean initial live weight 220 kg, were given a diet of barley and hay ad libitum. Each animal received a single oral does of 0, 5, 10, 20, or 40 g cupric oxide particles. A dose of 5 g cupric oxide particles increased liver copper stores for about 240 days and higher doses increased liver stores for longer but 40 g was no more effective than 20 g (85 mg/kg live weight). Variation among individuals was marked but the highest liver copper concentration recorded (7.59 mmol/kg dry matter) produced no biochemical evidence of copper toxicity. Cupric oxide particles were separated into three fractions, clumps, short rods and long; and 5 mg/kg live weight of each fraction given to steers of 173 kg mean live weight. The form of the particles did not affect either their retention in the alimentary tract or the accumulation of copper in the liver. [Suttle NF; Res Vet Sci 42 (2): 224-7 (1987)] PubMed Abstract
Ionic copper is absorbed from the stomach, duodenum, & jejunum. The initial absorption is about 30%, but the effective net absorption is only about 5% due to excretion of copper into the bile; biliary copper is bound to protein, & this complex is not reabsorbed. Absorption is influenced by a number of factors including the chemical forms of copper: oxides, hydroxides, iodides, glutamates, citrates, & pyrophosphates of copper are readily absorbed, but copper sulfides & other water insoluble salts are poorly absorbed. Copper complexes of some amino acids are easily absorbed, whereas copper porphyrins present in meat are very poorly absorbed. /Soluble copper salts/
The pulmonary uptake of copper oxide /occurred/ in rats exposed to aerosols containing 50-80 mg/cu m. Animals were exposed for 15, 30, 45, or 60 minutes and killed immediately. Another group was exposed for 180 minutes and killed at 0, 3, 6, 12, 18, or 24 hours after exposure. Electron microscopic histologic examination showed that absorption of copper had occurred in animals exposed for 180 minutes. Copper oxide particles penetrated the epithelial cells of alveoli and were found in plasma 6 hours after exposure began. Copper oxide was also observed in the proximal convoluted tubules of the kidney. /Copper oxide/

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2,4-Pentanedione; Cupric acetylacetonate; copper(II) 4-oxopent-2-en-2-olate; Copper(II)-2,4-pentanedionate; Copperpentanedionate; Copperacetylacetonat...

copper(ii) fluoride trihydrate

Copper (II) fluoride hydrate; Copper(II) fluoride dihydrate

COPPER(II) NITRATE HYDRATE

COPPER (II) NITRATE; CUPRIC NITRATE HYDRATE; CUPRIC NITRATE HYDRATED; copper(ii) nitrate hydrate, puratronic; Copper(II) nitrate hydrate, Puratronic(R...