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Home> CAS DataBase Listed 1 > CAS 103577-45-3
Identification of 103577-45-3
  • Name:
  • Lansoprazole (Related Reference)
  • Synonyms:
  • Amarin; Promp; Monolitum; Lanz; Prevacid (TN); Ulpax; Lansoprazolum [INN-Latin]; Takepron; Blason; 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole; Ilsatec; A 65006; Bamalite; Prevacid SoluTab; Lansopep; 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; Limpidex; Pro Ulco; Zoton; Lanproton; Lansoprazol [INN-Spanish]; Lansoprazole [USAN:BAN:INN]; Ogastro; 1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-; AG 1749; Dakar; 1H-Benzimidazole,2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-; Agopton; 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzoimidazole; Prosogan;
  • InChI:
  • InChI=1/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
  • This structure is also available as a 2d Mol file
Safety Data of 103577-45-3 Properties of 103577-45-3
  • Appearance:
  • White Crystalline Powder
  • Molecular Weight:
  • 369.36
  • Density:
  • 1.5 g/cm3
  • Boiling Point:
  • 555.8oC at 760 mmHg
  • Melting Point:
  • 178-182oC.
  • Flash Point:
  • 289.9 oC
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 1.591
  • Solubility:
  • Insoluble
  • Biological Activity:
  • H + ,K + -ATPase inhibitor (IC 50 = 6.3 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.09 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro . Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole ).
  • Usage:
  • Used as a gastric proton pump inhibitor. An antiulcerative

  • More>>

CAS No. 103577-45-3 (Lansoprazole )

  • CAS No:103577-45-3
  • Molecular Weight: 369.36
  • Molecular Formula: C16H14F3N3O2S
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
References of Lansoprazole cas 103577-45-3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 2gm/kg (2000mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 387, 1993.
mouse LD50 intraperitoneal > 5gm/kg (5000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
mouse LD50 oral > 5gm/kg (5000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
mouse LDLo intravenous 75mg/kg (75mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 905, 1996.
rat LD50 intraperitoneal 5gm/kg (5000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LD50 oral > 5gm/kg (5000mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat LDLo intravenous 58mg/kg (58mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 905, 1996.

Safety

Hazard Codes of Lansoprazole (CAS NO.103577-45-3):?IrritantXi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 2
RTECS: DD9487500