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Home> CAS DataBase Listed 1 > CAS 106266-06-2
Identification of 106266-06-2
  • Name:
  • Risperidal (Related Reference)
  • Synonyms:
  • Risperdal (TN); Risperidone; 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one; Apexidone; BRN 4891881; HSDB 7580; Psychodal; R 64 766; Risperdal Consta; Risperidona; Rispolept;
  • InChI:
  • InChI=1/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
  • This structure is also available as a 2d Mol file
Safety Data of 106266-06-2 Properties of 106266-06-2
  • Appearance:
  • crystalline solid
  • Molecular Weight:
  • 410.49 .
  • Density:
  • 1.38 g/cm3
  • Boiling Point:
  • 572.4 °C at 760 mmHg
  • Melting Point:
  • 170 °C
  • Flash Point:
  • 300 °C
  • Storage Temperature:
  • Room temp
  • Refractive index:
  • 1.676
  • Solubility:
  • Practically insoluble in water, freely soluble in methylene chloride and soluble in methanol and 0.1N hydrochloric acid
    In water, 2.16 mg/L at 25 deg C (est)
  • Biological Activity:
  • Atypical antipsychotic agent that displays 5-HT 2A receptor antagonism. Also displays high affinity at D 2 receptors (K i values are 0.4 and 3.13 nM for 5-HT 2A and D 2 receptors respectively).
  • Usage:
  • A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist

  • More>>

CAS No. 106266-06-2 (Risperidal )

  • CAS No:106266-06-2
  • Molecular Weight: 410.49 .
  • Molecular Formula: C23H27FN4O2
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
References of Risperidal cas 106266-06-2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 268ug/kg (0.268mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Annals of Pharmacotherpy. Vol. 30, Pg. 360, 1996.
?
dog LD50 intravenous 14100ug/kg (14.1mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
?
dog LD50 oral 18300ug/kg (18.3mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993.
man TDLo oral 114ug/kg/2D-I (0.114mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: EUPHORIA

BEHAVIORAL: EXCITEMENT
American Journal of Psychiatry. Vol. 153, Pg. 1234, 1996.
man TDLo oral 429ug/kg (0.429mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998.
?
man TDLo oral 429ug/kg/15D- (0.429mg/kg) BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING

BEHAVIORAL: ANOREXIA (HUMAN
Journal of Clinical Psychiatry. Vol. 58, Pg. 323, 1997.
man TDLo oral 3428ug/kg (3.428mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Annals of Emergency Medicine. Vol. 22, Pg. 1908, 1993.
?
man TDLo oral 3857ug/kg (3.857mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: PULSE RATE
Journal of Toxicology, Clinical Toxicology. Vol. 37, Pg. 893, 1999.
?
mouse LD50 intravenous 26900ug/kg (26.9mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
?
mouse LD50 oral 63100ug/kg (63.1mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
?
rat LD50 intravenous 34300ug/kg (34.3mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993.
rat LD50 oral 56600ug/kg (56.6mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 244, Pg. 685, 1988.
?
rat LD50 subcutaneous 98mg/kg (98mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 2991, 1993.
women TDLo oral 400ug/kg (0.4mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998.
?
women TDLo oral 880ug/kg (0.88mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
American Journal of Emergency Medicine. Vol. 16, Pg. 498, 1998.
?
women TDLo oral 1840ug/kg (1.84mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: HEADACHE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Clinical Psychiatry. Vol. 56, Pg. 514, 1995.
?
women TDLo oral 2mg/kg (2mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Clinical Pyschopharmacology. Vol. 17, Pg. 325, 1997.
women TDLo oral 2200ug/kg (2.2mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Therapie. Vol. 52, Pg. 155, 1997.
?
women TDLo oral 648mg/kg/77W- (648mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Journal of Clinical Psychiatry. Vol. 59, Pg. 478, 1998.

Safety

Hazard Codes:?ToxicT
Risk Statements: 25?
R25 :Toxic if swallowed.
Safety Statements: 28-36-45?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S36:Wear suitable protective clothing.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 3249
RTECS: UV1164800
HazardClass: 6.1(a)
PackingGroup: II