Ethylene glycol (cas 107-21-1) Molecular Structure

CAS No. 107-21-1 (Ethylene glycol )

Molecular Formula: C2H6O2Molecular Weight: 62.07

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References of Ethylene glycol cas 107-21-1

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 1650mg/kg (1650mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
cat LDLo subcutaneous 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS

BLOOD: OTHER CHANGES
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
child TDLo oral 5500mg/kg (5500mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Postgraduate Medical Journal. Vol. 52, Pg. 598, 1976.
dog LD50 oral 5500mg/kg (5500mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
guinea pig LD50 oral 6610mg/kg (6610mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LD50 unreported 11150mg/kg (11150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
guinea pig LDLo subcutaneous 5gm/kg (5000mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 51, Pg. 398, 1935.
human LDLo oral 398mg/kg (398mg/kg) BEHAVIORAL: HEADACHE

GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: OTHER CHANGES
Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. Vol. 26(2), Pg. 48, 1983.
human LDLo oral 786mg/kg (786mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: COMA
European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 373, 1976.
human TCLo inhalation 10000mg/m3 (10000mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: COUGH

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.
man LDLo unreported 1637mg/kg (1637mg/kg) "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 1195mg/kg (1195mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991.
man TDLo oral 15gm/kg (15000mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991.
man TDLo oral 16gm/kg (16000mg/kg) BEHAVIORAL: COMA

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
Human & Experimental Toxicology. Vol. 9, Pg. 317, 1990.
man TDLo oral 24gm/kg (24000mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 445, 2000.
mouse LC inhalation > 200mg/m3/2H (200mg/m3) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981.
mouse LD50 intraperitoneal 5614mg/kg (5614mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

BLOOD: CHANGES IN SPLEEN
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 intravenous 3gm/kg (3000mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.
mouse LD50 oral 5500mg/kg (5500mg/kg) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(3), Pg. 31, 1967.
mouse LD50 unreported 8050mg/kg (8050mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
mouse LDLo subcutaneous 2700mg/kg (2700mg/kg) British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944.
rabbit LD50 skin 9530uL/kg (9.53mL/kg) "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969.
rabbit LD50 unreported 5017mg/kg (5017mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT

GASTROINTESTINAL: NAUSEA OR VOMITING
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
rabbit LDLo intramuscular 5500mg/kg (5500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: COMA
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.
rabbit LDLo intraperitoneal 1gm/kg (1000mg/kg) Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 502, 1966.
rabbit LDLo intravenous 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.
rat LC inhalation > 200mg/m3/4H (200mg/m3) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981.
rat LD50 intraperitoneal 5010mg/kg (5010mg/kg) Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.
rat LD50 intravenous 3260mg/kg (3260mg/kg) Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.
rat LD50 oral 4700mg/kg (4700mg/kg) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 28, 1982.
rat LD50 subcutaneous 2800mg/kg (2800mg/kg) Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 49, 1974.
rat LD50 unreported 13gm/kg (13000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.
rat LDLo intramuscular 3300mg/kg (3300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.

Safety

Hazard Codes of Ethylene glycol (CAS NO.107-21-1): HarmfulXn
Risk Statements: 22-36
R22: Harmful if swallowed.
R36: Irritating to eyes.
Safety Statements: 26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1219 3/PG 2
WGK Germany: 3
RTECS: KW2975000
F: 3
HS Code: 29053100
Combustible when exposed to heat or flame; can react vigorously with oxidants. Moderate explosion hazard when exposed to flame. Ignites on contact with chromium trioxide, potassium permanganate, and sodium peroxide. Mixtures with ammonium dichromate, silver chlorate, sodium chlorite, and uranyl nitrate ignite when heated to 100°C. Can react violently with chlorosulfonic acid, oleum, H2SO4, HClO4, and P2S5. Aqueous solutions may ignite silvered copper wires that have an applied D.C. voltage. To fight fire, use alcohol foam, water, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.