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Home> CAS DataBase Listed 1 > CAS 109-99-9
Identification of 109-99-9
  • Name:
  • Tetrahydrofuran (Related Reference)
  • 203-726-8
  • Synonyms:
  • THF; tetrahydrofuran B&J brand 4 L; 99%; oxolane; Sodium tri-sec-butylborohydride; Tetrahydrofuran(Stabilized); TetrahydrofuranForHplc; TetrahydrofuranGr; TetrahydrofuranForSynthesis
  • InChI:
  • InChI=1/C4H8O/c1-2-4-5-3-1/h1-4H2
  • This structure is also available as a 2d Mol file
Safety Data of 109-99-9 Properties of 109-99-9
  • Appearance:
  • Clear liquid
  • Molecular Weight:
  • 72.11
  • Density:
  • 0.886g/cm3
  • Boiling Point:
  • 66℃
  • Melting Point:
  • -108.4℃
  • Flash Point:
  • -21℃
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 1.407
  • Solubility:
  • Miscible
  • Stability:
  • Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s
  • Usage:
  • Solvent for high polymer like polyvinyl chloride. As reaction medium for grignard & metal hydride reactions. In the synthesis of butyrolactone, succinic acid, 1,4-butanediol diacetate. Solvent in histological techniques and reverse phase hplc.

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CAS No. 109-99-9 (Tetrahydrofuran )

  • CAS No:109-99-9
  • Molecular Weight: 72.11
  • Molecular Formula: C4H8O
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
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  • Formula:C4H8O 
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  • Formula:C4H8O 
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  • Purity:99% 
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  • Appearance:white powder 
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Tetrahydrofuran for HPLC Grade
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2-Pyrrolidinone,polyvinyl pyrrolidone,1-Methyl-2-pyrrolidinone
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CAS No. 109-99-9 (Tetrahydrofuran )
  • FOB Price:1 USD/Kilogram 
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Precursor and Product
References of Tetrahydrofuran cas 109-99-9


Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 2300mg/kg (2300mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(9), Pg. 114, 1969.
guinea pig LDLo intraperitoneal 500mg/kg (500mg/kg) LIVER: FATTY LIVER DEGERATION American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.
human TCLo inhalation 25000ppm (25000ppm) BEHAVIORAL: GENERAL ANESTHETIC "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969.
mouse LCLo inhalation 24000mg/m3/2H (24000mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)


Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 5, Pg. 21, 1963.
mouse LD50 intraperitoneal 1900mg/kg (1900mg/kg) ? Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.
rabbit LC inhalation > 1200ppm/4H (1200ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 18, Pg. 89, 1982.
rat LC50 inhalation 21000ppm/3H (21000ppm) BEHAVIORAL: SLEEP


Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 20, Pg. 141, 1984.
rat LD50 intraperitoneal 2900mg/kg (2900mg/kg) ? Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.
rat LD50 oral 1650mg/kg (1650mg/kg) ? GAF Material Safety Data Sheet.


Hazard Codes?of Tetrahydrofuran (CAS NO.109-99-9):?IrritantXi,FlammableF
Risk Statements: 36/37/38-19-11?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R19: May form explosive peroxides.?
R11: Highly flammable.
Safety Statements: 26-36-33-29-16?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S33: Take precautionary measures against static discharges.?
S29: Do not empty into drains.?
S16: Keep away from sources of ignition.
RIDADR: UN 2924 3/PG 2
WGK Germany: 1
RTECS: MD0916000
F: 3-10-23
HazardClass: 3
PackingGroup: II
HS Code: 29321100
Hazardous Substances Data 109-99-9(Hazardous Substances Data)
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by inhalation: general anesthesia. Mutation data reported. Irritant to eyes and mucous membranes. Narcotic in high concentrations. Reported as causing injury to liver and kidneys.
?Flammable liquid. A very dangerous fire hazard when exposed to heat, flames, oxidizers. Explosive in the form of vapor when exposed to heat or flame. In common with ethers, unstabilized tetrahydrofuran forms thermally explosive peroxides on exposure to air. Stored THF must always be tested for peroxide prior to distillation. Peroxides can be removed by treatment with strong ferrous sulfate solution made slightly acidic with sodium bisulfate. Caustic alkalies deplete the inhibitor in THF and may subsequently cause an explosive reaction. Explosive reaction with KOH, NaAlH2, NaOH, sodium tetrahydroaluminate. Reacts with 2-aminophenol + potassium dioxide to form an explosive product. Reacts with lithium tetrahydroaluminate or borane to form explosive hydrogen gas. Violent reaction with metal halides (e.g., hafnium tetrachloride, titanium tetrachloride, zirconium tetrachloride). Vigorous reaction with bromine, calcium hydride + heat. Can react with oxidizing materials. To fight fire, use foam, dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also 2-TETRAHYDROFURYL HYDROPEROXIDE. ? ?