Solvent for high polymer like polyvinyl chloride. As reaction medium for grignard & metal hydride reactions. In the synthesis of butyrolactone, succinic acid, 1,4-butanediol diacetate. Solvent in histological techniques and reverse phase hplc.
|Organism||Test Type||Route||Reported Dose (Normalized Dose)||Effect||Source|
|guinea pig||LD50||oral||2300mg/kg (2300mg/kg)||?||Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(9), Pg. 114, 1969.|
|guinea pig||LDLo||intraperitoneal||500mg/kg (500mg/kg)||LIVER: FATTY LIVER DEGERATION||American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.|
|human||TCLo||inhalation||25000ppm (25000ppm)||BEHAVIORAL: GENERAL ANESTHETIC||"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969.|
|mouse||LCLo||inhalation||24000mg/m3/2H (24000mg/m3)||BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
|Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 5, Pg. 21, 1963.|
|mouse||LD50||intraperitoneal||1900mg/kg (1900mg/kg)||?||Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.|
|rabbit||LC||inhalation||> 1200ppm/4H (1200ppm)||SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION||Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 18, Pg. 89, 1982.|
|rat||LC50||inhalation||21000ppm/3H (21000ppm)||BEHAVIORAL: SLEEP
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
GASTROINTESTINAL: NAUSEA OR VOMITING
|Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 20, Pg. 141, 1984.|
|rat||LD50||intraperitoneal||2900mg/kg (2900mg/kg)||?||Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.|
|rat||LD50||oral||1650mg/kg (1650mg/kg)||?||GAF Material Safety Data Sheet.|
Hazard Codes?of Tetrahydrofuran (CAS NO.109-99-9):?Xi,F
Risk Statements: 36/37/38-19-11?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R19: May form explosive peroxides.?
R11: Highly flammable.
Safety Statements: 26-36-33-29-16?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S33: Take precautionary measures against static discharges.?
S29: Do not empty into drains.?
S16: Keep away from sources of ignition.
RIDADR: UN 2924 3/PG 2
WGK Germany: 1
HS Code: 29321100
Hazardous Substances Data 109-99-9(Hazardous Substances Data)
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by inhalation: general anesthesia. Mutation data reported. Irritant to eyes and mucous membranes. Narcotic in high concentrations. Reported as causing injury to liver and kidneys.
?Flammable liquid. A very dangerous fire hazard when exposed to heat, flames, oxidizers. Explosive in the form of vapor when exposed to heat or flame. In common with ethers, unstabilized tetrahydrofuran forms thermally explosive peroxides on exposure to air. Stored THF must always be tested for peroxide prior to distillation. Peroxides can be removed by treatment with strong ferrous sulfate solution made slightly acidic with sodium bisulfate. Caustic alkalies deplete the inhibitor in THF and may subsequently cause an explosive reaction. Explosive reaction with KOH, NaAlH2, NaOH, sodium tetrahydroaluminate. Reacts with 2-aminophenol + potassium dioxide to form an explosive product. Reacts with lithium tetrahydroaluminate or borane to form explosive hydrogen gas. Violent reaction with metal halides (e.g., hafnium tetrachloride, titanium tetrachloride, zirconium tetrachloride). Vigorous reaction with bromine, calcium hydride + heat. Can react with oxidizing materials. To fight fire, use foam, dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also 2-TETRAHYDROFURYL HYDROPEROXIDE.